{"id":567151,"date":"2026-10-09T12:30:00","date_gmt":"2026-10-09T10:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=567151"},"modified":"2026-09-21T11:25:35","modified_gmt":"2026-09-21T09:25:35","slug":"sglt2i-metformin-or-both","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/en\/sglt2i-metformin-or-both\/","title":{"rendered":"SGLT2i, metformin, or both?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Metformin remains the first-line drug therapy for newly diagnosed type 2 diabetes, while sodium-glucose cotransporter-2(SGLT2) inhibitors are indicated in the presence of established cardiovascular or renal disease or high cardiovascular risk. A study was conducted to determine whether early treatment with an SGLT2 inhibitor alters vascular function and structure in treatment-naive individuals with newly diagnosed T2D by comparing dapagliflozin monotherapy, metformin monotherapy, and their combination.<\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fsglt2i-metformin-or-both%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Metformin remains the first-line drug therapy for newly diagnosed type 2 diabetes, while sodium-glucose cotransporter-2(SGLT2) inhibitors are indicated in the presence of established cardiovascular or renal disease or high cardiovascular&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/en\/my-account\/packages\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/en\/log-in\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fen%2Fsglt2i-metformin-or-both%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":567152,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"First-line treatment for T2D","footnotes":"","_members_access_role":[],"_members_access_error":""},"category":[11548,11508,11384,11503],"tags":[19438,23427,11934,102294,11659,33416,86754,80048,12042],"powerkit_post_featured":[],"class_list":["post-567151","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-en","category-education","category-endocrinology-and-diabetology","category-studies","tag-cardiovascular-risk","tag-dapagliflozin-en","tag-first-line-therapy","tag-intima-media-thickness-of-the-carotid-artery","tag-metformin-en","tag-sglt2-inhibitors-en","tag-sglt2i","tag-t2d-en","tag-type-2-diabetes","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-10-16 15:00:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"en_US","wpml_translations":{"fr_FR":{"locale":"fr_FR","id":567157,"slug":"un-sglt2i-la-metformine-ou-les-deux","post_title":"Un SGLT2i, la metformine ou les deux ?","href":"https:\/\/medizinonline.com\/fr\/un-sglt2i-la-metformine-ou-les-deux\/"},"it_IT":{"locale":"it_IT","id":567049,"slug":"sglt2i-metformina-o-entrambi","post_title":"SGLT2i, metformina o entrambi?","href":"https:\/\/medizinonline.com\/it\/sglt2i-metformina-o-entrambi\/"},"pt_PT":{"locale":"pt_PT","id":567052,"slug":"sglt2i-metformina-ou-ambos","post_title":"SGLT2i, metformina ou ambos?","href":"https:\/\/medizinonline.com\/pt-pt\/sglt2i-metformina-ou-ambos\/"},"es_ES":{"locale":"es_ES","id":567060,"slug":"sglt2i-metformina-o-ambas","post_title":"\u00bfSGLT2i, metformina o ambas?","href":"https:\/\/medizinonline.com\/es\/sglt2i-metformina-o-ambas\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/567151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/comments?post=567151"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/567151\/revisions"}],"predecessor-version":[{"id":568099,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/posts\/567151\/revisions\/568099"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media\/567152"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/media?parent=567151"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/category?post=567151"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/tags?post=567151"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/en\/wp-json\/wp\/v2\/powerkit_post_featured?post=567151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}