{"id":408392,"date":"2025-09-30T13:30:00","date_gmt":"2025-09-30T11:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=408392"},"modified":"2025-09-11T10:23:59","modified_gmt":"2025-09-11T08:23:59","slug":"edicion-genica-intratumoral-mediada-por-nanoparticulas-de-pd-l1-y-galectina-9","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/es\/edicion-genica-intratumoral-mediada-por-nanoparticulas-de-pd-l1-y-galectina-9\/","title":{"rendered":"Edici\u00f3n g\u00e9nica intratumoral mediada por nanopart\u00edculas de PD-L1 y galectina-9"},"content":{"rendered":"\n<p><strong>Los inhibidores del punto de control inmunitario (ICI) han revolucionado la terapia oncol\u00f3gica, pero muchos pacientes no responden a esta forma de tratamiento o lo hacen s\u00f3lo de forma inadecuada. Mecanismos de resistencia como la sobreexpresi\u00f3n de PD-L1 o mol\u00e9culas inmunosupresoras como la galectina-9 limitan su eficacia. Un enfoque novedoso se dirige a la edici\u00f3n g\u00e9nica intratumoral dirigida mediante nanopart\u00edculas que introducen componentes CRISPR-Cas directamente en las c\u00e9lulas tumorales y desactivan en ellas genes reguladores. Un estudio reciente aporta pruebas precl\u00ednicas de que el silenciamiento combinado de PD-L1 y galectina-9 inhibe significativamente el crecimiento tumoral y mejora la eficacia de las terapias ICI.   <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/es\/mi-cuenta\/paquetes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">\u00bfYa eres miembro? <a href=\"https:\/\/medizinonline.com\/es\/conectarse\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fes%2Fedicion-genica-intratumoral-mediada-por-nanoparticulas-de-pd-l1-y-galectina-9%2F\">Accede aqu\u00ed<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Los inhibidores del punto de control inmunitario (ICI) han revolucionado la terapia oncol\u00f3gica, pero muchos pacientes no responden a esta forma de tratamiento o lo hacen s\u00f3lo de forma inadecuada&#8230;.&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/es\/mi-cuenta\/paquetes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">\u00bfYa eres miembro? <a href=\"https:\/\/medizinonline.com\/es\/conectarse\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fes%2Fedicion-genica-intratumoral-mediada-por-nanoparticulas-de-pd-l1-y-galectina-9%2F\">Accede aqu\u00ed<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":408394,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Nuevas perspectivas para la optimizaci\u00f3n de la inmunoterapia contra el c\u00e1ncer","footnotes":""},"category":[11475,11478,11336,11552],"tags":[85230,13555,41999],"powerkit_post_featured":[],"class_list":["post-408392","post","type-post","status-publish","format-standard","has-post-thumbnail","category-estudios","category-formacion-continua","category-oncologia","category-rx-es","tag-galectina-9-es","tag-inmunoterapia","tag-pd-l1-es","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-16 15:34:34","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"es_ES","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts\/408392","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/comments?post=408392"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts\/408392\/revisions"}],"predecessor-version":[{"id":408396,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts\/408392\/revisions\/408396"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/media\/408394"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/media?parent=408392"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/category?post=408392"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/tags?post=408392"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/powerkit_post_featured?post=408392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}