{"id":557171,"date":"2026-06-06T12:42:24","date_gmt":"2026-06-06T10:42:24","guid":{"rendered":"https:\/\/medizinonline.com\/estabilizadores-de-la-ttr-silenciamiento-y-tijeras-geneticas-en-que-punto-nos-encontramos\/"},"modified":"2026-06-06T12:42:32","modified_gmt":"2026-06-06T10:42:32","slug":"estabilizadores-de-la-ttr-silenciamiento-y-tijeras-geneticas-en-que-punto-nos-encontramos","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/es\/estabilizadores-de-la-ttr-silenciamiento-y-tijeras-geneticas-en-que-punto-nos-encontramos\/","title":{"rendered":"Estabilizadores de la TTR, silenciamiento y tijeras gen\u00e9ticas: \u00bfen qu\u00e9 punto nos encontramos?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Los avances en la comprensi\u00f3n de la fisiopatolog\u00eda de la miocardiopat\u00eda amiloide por transtiretina (ATTR-CM) han revolucionado el panorama terap\u00e9utico en los \u00faltimos a\u00f1os. Los estabilizadores de la TTR como el tafamidis y el acoramidis pueden reducir la inestabilidad de la TTR y la subsiguiente formaci\u00f3n de fibrillas amiloides, y las terapias de silenciamiento g\u00e9nico con peque\u00f1os ARN interferentes como el patisiran y el vutrisiran o inhibidores de oligonucle\u00f3tidos antisentido como el inotersen y el eplontersen tambi\u00e9n representan opciones terap\u00e9uticas prometedoras, ya que reducen la producci\u00f3n de TTR. En los estudios en curso se est\u00e1n investigando otros silenciadores g\u00e9nicos, terapias g\u00e9nicas y estrategias de tratamiento combinadas.    <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/es\/mi-cuenta\/paquetes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">\u00bfYa eres miembro? <a href=\"https:\/\/medizinonline.com\/es\/conectarse\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fes%2Festabilizadores-de-la-ttr-silenciamiento-y-tijeras-geneticas-en-que-punto-nos-encontramos%2F\">Accede aqu\u00ed<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Los avances en la comprensi\u00f3n de la fisiopatolog\u00eda de la miocardiopat\u00eda amiloide por transtiretina (ATTR-CM) han revolucionado el panorama terap\u00e9utico en los \u00faltimos a\u00f1os. Los estabilizadores de la TTR como&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/es\/mi-cuenta\/paquetes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">\u00bfYa eres miembro? <a href=\"https:\/\/medizinonline.com\/es\/conectarse\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fes%2Festabilizadores-de-la-ttr-silenciamiento-y-tijeras-geneticas-en-que-punto-nos-encontramos%2F\">Accede aqu\u00ed<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":557172,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Terapias modificadoras de la enfermedad para la ATTR-CM","footnotes":""},"category":[11552,11324,11483,11475,11364],"tags":[94120,94118,94119,74880,74877,94116,94121,94117,74885],"powerkit_post_featured":[],"class_list":["post-557171","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-es","category-cardiologia","category-el-congreso-informa","category-estudios","category-genetica","tag-attr-cm","tag-estabilizadores-ttr","tag-inhibidores-de-oligonucleotidos-antisentido","tag-inotersen-es","tag-patisiran-es","tag-silenciamiento-de-genes","tag-terapias-modificadoras-de-la-enfermedad","tag-tijeras-gene","tag-vutrisiran-es","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-27 06:57:28","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"es_ES","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts\/557171","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/comments?post=557171"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts\/557171\/revisions"}],"predecessor-version":[{"id":557173,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts\/557171\/revisions\/557173"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/media\/557172"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/media?parent=557171"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/category?post=557171"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/tags?post=557171"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/powerkit_post_featured?post=557171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}