{"id":564282,"date":"2026-09-25T12:30:00","date_gmt":"2026-09-25T10:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=564282"},"modified":"2026-09-21T10:57:45","modified_gmt":"2026-09-21T08:57:45","slug":"moleculas-pequenas-de-aplicacion-topica-las-janusquinasas-o-la-pde-4-como-diana","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/es\/moleculas-pequenas-de-aplicacion-topica-las-janusquinasas-o-la-pde-4-como-diana\/","title":{"rendered":"\u00abMol\u00e9culas peque\u00f1as\u00bb de aplicaci\u00f3n t\u00f3pica: \u00bflas janusquinasas o la PDE-4 como diana?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Las estructuras intracelulares diana, como puntos de acci\u00f3n terap\u00e9utica de los f\u00e1rmacos de bajo peso molecular en la dermatitis at\u00f3pica (DA), han cobrado importancia, y la formulaci\u00f3n t\u00f3pica garantiza un efecto farmacol\u00f3gico local, lo que favorece un perfil de seguridad beneficioso [1,2]. En algunos pa\u00edses, los inhibidores t\u00f3picos de la Janus quinasa (JAK) para la indicaci\u00f3n de la DA han superado los obst\u00e1culos de autorizaci\u00f3n; por ejemplo, el delgocitinib est\u00e1 autorizado en Jap\u00f3n y el ruxolitinib, adem\u00e1s de en EE. UU., se ha autorizado recientemente tambi\u00e9n en la UE. En cuanto a los inhibidores t\u00f3picos de la fosfodiesterasa (PDE) 4, adem\u00e1s de Crisaborol y Roflumilast, recientemente tambi\u00e9n se ha concedido la autorizaci\u00f3n de la FDA a Difamilast.  <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/es\/mi-cuenta\/paquetes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">\u00bfYa eres miembro? <a href=\"https:\/\/medizinonline.com\/es\/conectarse\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fes%2Fmoleculas-pequenas-de-aplicacion-topica-las-janusquinasas-o-la-pde-4-como-diana%2F\">Accede aqu\u00ed<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Las estructuras intracelulares diana, como puntos de acci\u00f3n terap\u00e9utica de los f\u00e1rmacos de bajo peso molecular en la dermatitis at\u00f3pica (DA), han cobrado importancia, y la formulaci\u00f3n t\u00f3pica garantiza un&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/es\/mi-cuenta\/paquetes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">\u00bfYa eres miembro? <a href=\"https:\/\/medizinonline.com\/es\/conectarse\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fes%2Fmoleculas-pequenas-de-aplicacion-topica-las-janusquinasas-o-la-pde-4-como-diana%2F\">Accede aqu\u00ed<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":564283,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Dermatitis at\u00f3pica en ni\u00f1os y adultos  ","footnotes":"","_members_access_role":[],"_members_access_error":""},"category":[11552,11298,11310,11475,11408,11478],"tags":[94972,100365,80579,12531,80578,100364,68895,15601,100362,100367,100369,73327,80577,12599,100360],"powerkit_post_featured":[],"class_list":["post-564282","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-es","category-alergologia-e-inmunologia-clinica","category-dermatologia-y-venereologia","category-estudios","category-farmacologia-y-toxicologia","category-formacion-continua","tag-crisaborol","tag-crisade-control","tag-delgocitinib-es","tag-dermatitis-atopica","tag-difamilast-es","tag-integumento","tag-janus-quinasas","tag-moleculas-pequenas","tag-pde-4","tag-qba4-1","tag-qba4-2","tag-roflumilast-es","tag-ruxolitinib-es","tag-terapia-topica-es","tag-true-ad","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-10-02 13:28:37","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"es_ES","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts\/564282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/comments?post=564282"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts\/564282\/revisions"}],"predecessor-version":[{"id":566930,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/posts\/564282\/revisions\/566930"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/media\/564283"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/media?parent=564282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/category?post=564282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/tags?post=564282"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/es\/wp-json\/wp\/v2\/powerkit_post_featured?post=564282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}