{"id":324843,"date":"2022-09-02T16:55:49","date_gmt":"2022-09-02T14:55:49","guid":{"rendered":"https:\/\/medizinonline.com\/cellules-impliquees-et-medicament-de-soutien-identifies\/"},"modified":"2022-09-02T16:55:49","modified_gmt":"2022-09-02T14:55:49","slug":"cellules-impliquees-et-medicament-de-soutien-identifies","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/cellules-impliquees-et-medicament-de-soutien-identifies\/","title":{"rendered":"Cellules impliqu\u00e9es et m\u00e9dicament de soutien identifi\u00e9s"},"content":{"rendered":"<p><strong>La r\u00e9g\u00e9n\u00e9ration dans le SNC est un \u00e9v\u00e9nement rare et fortement limit\u00e9 au remplacement des cellules dites oligodendrogliales et de leurs \u00e9l\u00e9ments \u00e9lectriquement isolants des axones, appel\u00e9s gaines de my\u00e9line. Cela vaut \u00e9galement pour la scl\u00e9rose en plaques (SEP). L&#8217;\u00e9quipe du professeur Patrick K\u00fcry, de la clinique de neurologie de l&#8217;h\u00f4pital universitaire de D\u00fcsseldorf, d\u00e9crit dans Lancet EBioMedicine que le corticost\u00e9ro\u00efde Medryson favorise tr\u00e8s efficacement le remplacement des cellules oligodendrogliales perdues ainsi que la restauration des gaines de my\u00e9line et donc l&#8217;isolation \u00e9lectrique des axones. L&#8217;effet r\u00e9g\u00e9n\u00e9rateur de Medryson a \u00e9t\u00e9 obtenu par l&#8217;interm\u00e9diaire d&#8217;un type de cellules totalement inattendu : les astrocytes.<\/strong><\/p>\n<p> <!--more--> <\/p>\n<p><span style=\"color:rgb(34, 34, 34); font-family:helvetica neue,helveticaneue,helvetica,arial,lucida grande,sans-serif\">La publication de l&#8217;\u00e9tude sur le mod\u00e8le de souris autour du premier auteur Markley Silva Oliveira Junior, un doctorant br\u00e9silien talentueux dans le groupe de travail de D\u00fcsseldorf, vient de para\u00eetre.<\/span><\/p>\n<p>\n<span style=\"color:rgb(34, 34, 34); font-family:helvetica neue,helveticaneue,helvetica,arial,lucida grande,sans-serif\">Les scientifiques ont pu montrer pour la premi\u00e8re fois que les astrocytes r\u00e9agissent de mani\u00e8re sp\u00e9cifique dans les situations o\u00f9 les structures de my\u00e9line sont endommag\u00e9es et qu&#8217;ils se pr\u00e9sentent sous de nombreux sous-types diff\u00e9rents. Certains de ces ph\u00e9notypes tentent de soutenir les activit\u00e9s de r\u00e9paration tissulaire locale, d&#8217;autres sont plus orient\u00e9s vers une destruction tissulaire plus importante et contribuent m\u00eame \u00e0 la formation de l\u00e9sions suppl\u00e9mentaires. Un comportement tr\u00e8s complexe et dynamique a \u00e9t\u00e9 observ\u00e9, mais il peut \u00eatre orient\u00e9 par le m\u00e9dicament Medryson vers des cellules protectrices et r\u00e9g\u00e9n\u00e9ratrices et vers la &#8220;domestication&#8221; des populations d&#8217;astrocytes neurotoxiques.&nbsp;<\/span><\/p>\n<p><span style=\"color:rgb(34, 34, 34); font-family:helvetica neue,helveticaneue,helvetica,arial,lucida grande,sans-serif\">Ces r\u00e9sultats sont inattendus et nouveaux dans le domaine de la neuror\u00e9g\u00e9n\u00e9ration dans la SEP.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h5 id=\"publication-originale\"><span style=\"font-size:14px\">Publication originale :<\/span><\/h5>\n<p>Silva Oliveira-Junior, M., Schira-Heinen, J., Reiche, L., Han, S., de Amorim, V.C.M., Lewen, I., Gruchot, J., G\u00f6ttle, P., Akkermann, R., Azim, K., and K\u00fcry, P. (2022) La r\u00e9paration de la my\u00e9line est favoris\u00e9e par la m\u00e9drysone corticost\u00e9ro\u00efde agissant sp\u00e9cifiquement sur les sous-populations astrogliales. EBioMedicine 83:104204. doi : 10.1016\/j.ebiom.2022.104204. (Online ahead of print).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La r\u00e9g\u00e9n\u00e9ration dans le SNC est un \u00e9v\u00e9nement rare et fortement limit\u00e9 au remplacement des cellules dites oligodendrogliales et de leurs \u00e9l\u00e9ments \u00e9lectriquement isolants des axones, appel\u00e9s gaines de my\u00e9line.&hellip;<\/p>\n","protected":false},"author":16,"featured_media":124746,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"La neuror\u00e9g\u00e9n\u00e9ration dans la scl\u00e9rose en plaques","footnotes":""},"category":[11527,11383,11549],"tags":[],"powerkit_post_featured":[],"class_list":["post-324843","post","type-post","status-publish","format-standard","has-post-thumbnail","category-etudes","category-neurologie-fr","category-rx-fr","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-01 10:36:23","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"fr_FR","wpml_translations":{"it_IT":{"locale":"it_IT","id":324845,"slug":"identificazione-delle-cellule-coinvolte-e-dei-farmaci-di-supporto","post_title":"Identificazione delle cellule coinvolte e dei farmaci di supporto","href":"https:\/\/medizinonline.com\/it\/identificazione-delle-cellule-coinvolte-e-dei-farmaci-di-supporto\/"},"pt_PT":{"locale":"pt_PT","id":324854,"slug":"celulas-envolvidas-e-droga-de-apoio-identificada","post_title":"C\u00e9lulas envolvidas e droga de apoio identificada","href":"https:\/\/medizinonline.com\/pt-pt\/celulas-envolvidas-e-droga-de-apoio-identificada\/"},"es_ES":{"locale":"es_ES","id":324856,"slug":"celulas-implicadas-y-farmaco-de-apoyo-identificado","post_title":"C\u00e9lulas implicadas y f\u00e1rmaco de apoyo identificado","href":"https:\/\/medizinonline.com\/es\/celulas-implicadas-y-farmaco-de-apoyo-identificado\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/324843","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/comments?post=324843"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/324843\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media\/124746"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media?parent=324843"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/category?post=324843"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/tags?post=324843"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/powerkit_post_featured?post=324843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}