{"id":325539,"date":"2022-06-16T14:00:00","date_gmt":"2022-06-16T12:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/meilleure-reponse-a-limmunotherapie-apres-une-transplantation-fecale\/"},"modified":"2022-06-16T14:00:00","modified_gmt":"2022-06-16T12:00:00","slug":"meilleure-reponse-a-limmunotherapie-apres-une-transplantation-fecale","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/meilleure-reponse-a-limmunotherapie-apres-une-transplantation-fecale\/","title":{"rendered":"Meilleure r\u00e9ponse \u00e0 l&#8217;immunoth\u00e9rapie apr\u00e8s une transplantation f\u00e9cale"},"content":{"rendered":"<p><strong>Une \u00e9quipe de recherche impliquant le <em>National Cancer Institute <\/em>am\u00e9ricain a \u00e9tudi\u00e9 les effets d&#8217;une transplantation de microbiote f\u00e9cal sur l&#8217;effet du pembrolizumab dans une \u00e9tude de preuve de concept chez des patients atteints de m\u00e9lanome m\u00e9tastatique r\u00e9fractaire aux anticorps PD1.<\/strong><\/p>\n<p> <!--more--> <\/p>\n<p>La transplantation de microbiote f\u00e9cal (FMT) est une approche de modulation th\u00e9rapeutique cibl\u00e9e du microbiote intestinal. 15 patients atteints de m\u00e9lanome qui n&#8217;avaient pas r\u00e9pondu au pembrolizumab ou au nivolumab ont re\u00e7u une greffe f\u00e9cale de patients atteints de m\u00e9lanome avanc\u00e9 qui avaient r\u00e9pondu au pembrolizumab. Apr\u00e8s la transplantation f\u00e9cale, les patients ont \u00e9t\u00e9 trait\u00e9s par pembrolizumab. Chez 6 des 15 participants \u00e0 l&#8217;\u00e9tude, une r\u00e9duction de la tumeur ou une stabilisation \u00e0 long terme a \u00e9t\u00e9 observ\u00e9e apr\u00e8s cette intervention. Chez un des patients, une r\u00e9ponse partielle persistante a \u00e9t\u00e9 observ\u00e9e apr\u00e8s plus de 2 ans, et chez 4 autres, la maladie n&#8217;a pas progress\u00e9 depuis plus d&#8217;un an. &#8220;Notre \u00e9tude est l&#8217;une des premi\u00e8res \u00e0 montrer chez des patients qu&#8217;une modification de la composition du microbiome intestinal peut am\u00e9liorer la r\u00e9ponse \u00e0 l&#8217;immunoth\u00e9rapie. Les donn\u00e9es d\u00e9montrent que le microbiome intestinal peut \u00eatre une cible th\u00e9rapeutique dans le cancer&#8221;, a expliqu\u00e9 le Dr Giorgio Trinchieri, responsable de l&#8217;\u00e9tude.<br \/>\n&nbsp;<\/p>\n<p>Litt\u00e9rature compl\u00e9mentaire :<\/p>\n<ol>\n<li>Heinzl S : Medscape Onko-Newsblog, 09.02.2021, https:\/\/deutsch.medscape.com\/artikelansicht\/4909695#vp_2, (derni\u00e8re consultation 11.03.2022)<\/li>\n<li>Davar D, et al. La transplantation de microbiote f\u00e9cal surmonte la r\u00e9sistance au traitement anti-PD-1 chez les patients atteints de m\u00e9lanome. Science. 4 f\u00e9vrier 2021. DOI : 10.1126\/science.abf3363, (derni\u00e8re consultation 11.03.2022)<\/li>\n<li>&#8220;Fecal microbiota transplants help patients with advanced melanoma respond to immunotherapy&#8221;, 04.02.2021, www.cancer.gov\/news-events\/press-releases\/2021\/fecal-transplants-cancer-immunotherapy?cid=eb_govdel (derni\u00e8re consultation 11.03.2022)<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><em>DERMATOLOGIE PRATIQUE 2022 ; 32(2) : 47<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Une \u00e9quipe de recherche impliquant le National Cancer Institute am\u00e9ricain a \u00e9tudi\u00e9 les effets d&#8217;une transplantation de microbiote f\u00e9cal sur l&#8217;effet du pembrolizumab dans une \u00e9tude de preuve de concept&hellip;<\/p>\n","protected":false},"author":7,"featured_media":120149,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"M\u00e9lanome m\u00e9tastas\u00e9","footnotes":""},"category":[11362,11527,11531,11414,11315,11389,11549],"tags":[12368,15459],"powerkit_post_featured":[],"class_list":["post-325539","post","type-post","status-publish","format-standard","has-post-thumbnail","category-dermatologie-et-venerologie","category-etudes","category-formation-continue","category-gastro-enterologie-et-hepatologie","category-medecine-interne-generale","category-oncologie","category-rx-fr","tag-melanome","tag-transplantation-de-selles","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-29 11:19:16","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"fr_FR","wpml_translations":{"it_IT":{"locale":"it_IT","id":325541,"slug":"migliore-risposta-allimmunoterapia-dopo-il-trapianto-di-feci","post_title":"Migliore risposta all'immunoterapia dopo il trapianto di feci","href":"https:\/\/medizinonline.com\/it\/migliore-risposta-allimmunoterapia-dopo-il-trapianto-di-feci\/"},"pt_PT":{"locale":"pt_PT","id":325518,"slug":"melhor-resposta-a-imunoterapia-apos-transplante-de-fezes","post_title":"Melhor resposta \u00e0 imunoterapia ap\u00f3s transplante de fezes","href":"https:\/\/medizinonline.com\/pt-pt\/melhor-resposta-a-imunoterapia-apos-transplante-de-fezes\/"},"es_ES":{"locale":"es_ES","id":325520,"slug":"mejor-respuesta-a-la-inmunoterapia-tras-el-trasplante-de-heces","post_title":"Mejor respuesta a la inmunoterapia tras el trasplante de heces","href":"https:\/\/medizinonline.com\/es\/mejor-respuesta-a-la-inmunoterapia-tras-el-trasplante-de-heces\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/325539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/comments?post=325539"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/325539\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media\/120149"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media?parent=325539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/category?post=325539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/tags?post=325539"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/powerkit_post_featured?post=325539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}