{"id":334079,"date":"2020-06-17T00:01:00","date_gmt":"2020-06-16T22:01:00","guid":{"rendered":"https:\/\/medizinonline.com\/amelioration-significative-du-covid-19-avec-le-tocilizumab\/"},"modified":"2020-06-17T00:01:00","modified_gmt":"2020-06-16T22:01:00","slug":"amelioration-significative-du-covid-19-avec-le-tocilizumab","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/amelioration-significative-du-covid-19-avec-le-tocilizumab\/","title":{"rendered":"Am\u00e9lioration significative du COVID-19 avec le tocilizumab"},"content":{"rendered":"<p><strong>Chez les patients atteints de pneumonie COVID-19, on pense qu&#8217;une &#8220;temp\u00eate de cytokines&#8221; \u00e0 m\u00e9diation immunitaire entra\u00eene une insuffisance respiratoire aigu\u00eb et la mort. La plate-forme CORIMUNO-19 a \u00e9t\u00e9 rapidement d\u00e9velopp\u00e9e et mise en place pour \u00e9valuer l&#8217;efficacit\u00e9 et la tol\u00e9rance de diff\u00e9rents immunomodulateurs et autres traitements chez des patients adultes atteints d&#8217;une infection s\u00e9v\u00e8re par COVID-19, au moyen d&#8217;une s\u00e9rie d&#8217;essais randomis\u00e9s contr\u00f4l\u00e9s multicentriques. Le point de d\u00e9part \u00e9tait le 27 mars 2020.<\/strong><\/p>\n<p> <!--more--> <\/p>\n<p>L&#8217;\u00e9tude CORIMUNO-TOCI a \u00e9valu\u00e9 l&#8217;effet du tocilizumab, un anticorps monoclonal qui bloque le r\u00e9cepteur de la cytokine interleukine-6 et qui est utilis\u00e9 en clinique notamment dans le traitement de la polyarthrite rhumato\u00efde. Ont \u00e9t\u00e9 s\u00e9lectionn\u00e9s les patients hospitalis\u00e9s pour une pneumonie COVID-19 mod\u00e9r\u00e9e ou s\u00e9v\u00e8re et pour lesquels des soins intensifs n&#8217;\u00e9taient pas n\u00e9cessaires \u00e0 l&#8217;admission.<\/p>\n<p>Le crit\u00e8re d&#8217;\u00e9valuation composite primaire \u00e9tait la n\u00e9cessit\u00e9 d&#8217;une ventilation (non invasive ou m\u00e9canique) ou le d\u00e9c\u00e8s au 14\u00e8me jour&nbsp;. Au total, 129 patients ont \u00e9t\u00e9 randomis\u00e9s : 65 selon le standard de soins + tocilizumab et 64 selon le standard de soins seul. Une proportion significativement plus faible de patients a atteint le r\u00e9sultat primaire dans le bras tocilizumab. Les r\u00e9sultats de cette \u00e9tude seront soumis pour publication dans un journal \u00e0 comit\u00e9 de lecture.<\/p>\n<p>Ces r\u00e9sultats devraient \u00eatre confirm\u00e9s de mani\u00e8re ind\u00e9pendante par des \u00e9tudes suppl\u00e9mentaires. Compte tenu du contexte pand\u00e9mique, les chercheurs et le sponsor se sont sentis oblig\u00e9s, d&#8217;un point de vue \u00e9thique, de divulguer ces informations jusqu&#8217;\u00e0 ce qu&#8217;une \u00e9valuation par les pairs ait eu lieu et que des mesures de suivi plus longues aient \u00e9t\u00e9 prises. D&#8217;autres \u00e9tudes CORIMUNO, testant d&#8217;autres inhibiteurs des r\u00e9cepteurs de l&#8217;IL-6 et d&#8217;autres immunomodulateurs, sont en cours d&#8217;analyse. La plateforme d&#8217;essai CORIMUNO-19 est sponsoris\u00e9e et financ\u00e9e par l&#8217;Assistance Publique-H\u00f4pitaux de Paris et soutenue par Reacting \/ INSERM.<\/p>\n<p>\n<em>Source : H\u00f4pitaux de Paris \/ Universit\u00e4tskliniken Paris<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><em>InFo PNEUMOLOGIE &amp; ALLERGOLOGIE 2020 ; 2(2) : 4 (publi\u00e9 le 17.6.20, ahead of print)<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chez les patients atteints de pneumonie COVID-19, on pense qu&#8217;une &#8220;temp\u00eate de cytokines&#8221; \u00e0 m\u00e9diation immunitaire entra\u00eene une insuffisance respiratoire aigu\u00eb et la mort. La plate-forme CORIMUNO-19 a \u00e9t\u00e9 rapidement&hellip;<\/p>\n","protected":false},"author":7,"featured_media":97447,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"\u00c9tude CORIMUNO-TOCI  ","footnotes":""},"category":[11523,11527,11428,11477,11549],"tags":[13253,13255],"powerkit_post_featured":[],"class_list":["post-334079","post","type-post","status-publish","format-standard","has-post-thumbnail","category-actualites","category-etudes","category-infectiologie","category-pneumologie-fr","category-rx-fr","tag-corona-fr","tag-covid-fr","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-27 14:53:45","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"fr_FR","wpml_translations":{"it_IT":{"locale":"it_IT","id":334081,"slug":"miglioramento-significativo-della-covid-19-con-tocilizumab","post_title":"Miglioramento significativo della COVID-19 con tocilizumab","href":"https:\/\/medizinonline.com\/it\/miglioramento-significativo-della-covid-19-con-tocilizumab\/"},"pt_PT":{"locale":"pt_PT","id":334036,"slug":"melhoria-significativa-da-covid-19-com-tocilizumab","post_title":"Melhoria significativa da COVID-19 com tocilizumab","href":"https:\/\/medizinonline.com\/pt-pt\/melhoria-significativa-da-covid-19-com-tocilizumab\/"},"es_ES":{"locale":"es_ES","id":334046,"slug":"mejora-significativa-de-covid-19-con-tocilizumab","post_title":"Mejora significativa de COVID-19 con tocilizumab","href":"https:\/\/medizinonline.com\/es\/mejora-significativa-de-covid-19-con-tocilizumab\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/334079","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/comments?post=334079"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/334079\/revisions"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media?parent=334079"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/category?post=334079"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/tags?post=334079"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/powerkit_post_featured?post=334079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}