{"id":335897,"date":"2019-07-31T00:00:00","date_gmt":"2019-07-30T22:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/utilisation-precoce-des-inhibiteurs-cdk4-6-etudiee\/"},"modified":"2019-07-31T00:00:00","modified_gmt":"2019-07-30T22:00:00","slug":"utilisation-precoce-des-inhibiteurs-cdk4-6-etudiee","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/utilisation-precoce-des-inhibiteurs-cdk4-6-etudiee\/","title":{"rendered":"Utilisation pr\u00e9coce des inhibiteurs CDK4\/6 \u00e9tudi\u00e9e"},"content":{"rendered":"<p><strong>Les th\u00e9rapies cibl\u00e9es sont actuellement utilis\u00e9es principalement dans le cancer du sein localement avanc\u00e9 ou m\u00e9tastas\u00e9. Des donn\u00e9es d&#8217;\u00e9tudes r\u00e9centes indiquent d\u00e9sormais que les personnes atteintes \u00e0 des stades plus pr\u00e9coces pourraient \u00e9galement en b\u00e9n\u00e9ficier.<\/strong><\/p>\n<p> <!--more--> <\/p>\n<p>Les inhibiteurs de CDK4\/6 ont d\u00e9j\u00e0 fait la preuve de leur efficacit\u00e9 dans le cancer du sein avanc\u00e9 ou m\u00e9tastatique. Ils sont associ\u00e9s \u00e0 un allongement consid\u00e9rable de la p\u00e9riode de non-progression en combinaison avec un traitement antihormonal. Ils sont d\u00e9sormais devenus le traitement standard des cancers m\u00e9tastatiques endocrinosensibles. En raison de leur r\u00e9ponse positive et de leur bonne tol\u00e9rance, les pr\u00e9parations ont d\u00e9sormais \u00e9t\u00e9 \u00e9tudi\u00e9es dans les tumeurs endocrino-sensibles au stade pr\u00e9coce de la maladie.<\/p>\n<p>Le d\u00e9rapage de la croissance cellulaire est notamment d\u00fb \u00e0 une mauvaise r\u00e9gulation du cycle cellulaire, qui est contr\u00f4l\u00e9 par les cyclines et les kinases d\u00e9pendantes des cyclines (CDK). L&#8217;interaction avec la cycline D active les CDK4\/6, qui se sont av\u00e9r\u00e9s \u00eatre des r\u00e9gulateurs du cycle cellulaire. En phosphorylant la prot\u00e9ine supresseur de tumeur de r\u00e9tinoblastome, ils d\u00e9clenchent la transition de la phase G1 \u00e0 la phase S prolif\u00e9rative du cycle cellulaire. En cons\u00e9quence, l&#8217;inhibition des kinases d\u00e9pendantes de la cycline peut freiner la division cellulaire.<\/p>\n<h2 id=\"utilisation-neo-adjuvante\">Utilisation n\u00e9o-adjuvante<\/h2>\n<p>Une fois le diagnostic pos\u00e9, les inhibiteurs de CDK4\/6 ont \u00e9t\u00e9 administr\u00e9s pendant deux ou quatre semaines et la valeur KI-67 a \u00e9t\u00e9 mesur\u00e9e comme preuve de la r\u00e9ponse. Il s&#8217;est av\u00e9r\u00e9 que les m\u00e9dicaments pouvaient parfois ralentir consid\u00e9rablement la prolif\u00e9ration, m\u00eame sans traitement endocrinien suppl\u00e9mentaire. L&#8217;objectif serait de r\u00e9duire consid\u00e9rablement le risque de m\u00e9tastases.<\/p>\n<p><em>Source : Congr\u00e8s St. Gallen International Breast Cancer Conference 2019<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><em>InFo ONKOLOGIE &amp; H\u00c4MATOLOGIE 2019 ; 7(2-3) : 38 (publi\u00e9 le 21.6.19, ahead of print)<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Les th\u00e9rapies cibl\u00e9es sont actuellement utilis\u00e9es principalement dans le cancer du sein localement avanc\u00e9 ou m\u00e9tastas\u00e9. Des donn\u00e9es d&#8217;\u00e9tudes r\u00e9centes indiquent d\u00e9sormais que les personnes atteintes \u00e0 des stades plus&hellip;<\/p>\n","protected":false},"author":7,"featured_media":90297,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Cancer du sein","footnotes":""},"category":[11422,11389,11535,11549],"tags":[13596,13591,17044,28245],"powerkit_post_featured":[],"class_list":["post-335897","post","type-post","status-publish","format-standard","has-post-thumbnail","category-gynecologie","category-oncologie","category-rapports-de-congres","category-rx-fr","tag-cancer-du-sein-fr","tag-cancer-du-sein","tag-therapie-ciblee","tag-traitement-neo-adjuvant","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-30 12:03:58","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"fr_FR","wpml_translations":{"it_IT":{"locale":"it_IT","id":335907,"slug":"indagato-luso-precoce-degli-inibitori-di-cdk4-6","post_title":"Indagato l'uso precoce degli inibitori di CDK4\/6","href":"https:\/\/medizinonline.com\/it\/indagato-luso-precoce-degli-inibitori-di-cdk4-6\/"},"pt_PT":{"locale":"pt_PT","id":335914,"slug":"utilizacao-precoce-dos-inibidores-cdk4-6-investigados","post_title":"Utiliza\u00e7\u00e3o precoce dos inibidores CDK4\/6 investigados","href":"https:\/\/medizinonline.com\/pt-pt\/utilizacao-precoce-dos-inibidores-cdk4-6-investigados\/"},"es_ES":{"locale":"es_ES","id":335877,"slug":"se-investiga-el-uso-precoz-de-los-inhibidores-cdk4-6","post_title":"Se investiga el uso precoz de los inhibidores CDK4\/6","href":"https:\/\/medizinonline.com\/es\/se-investiga-el-uso-precoz-de-los-inhibidores-cdk4-6\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/335897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/comments?post=335897"}],"version-history":[{"count":0,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/335897\/revisions"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media?parent=335897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/category?post=335897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/tags?post=335897"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/powerkit_post_featured?post=335897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}