{"id":367940,"date":"2023-10-03T18:11:45","date_gmt":"2023-10-03T16:11:45","guid":{"rendered":"https:\/\/medizinonline.com\/?p=367940"},"modified":"2023-11-06T14:39:30","modified_gmt":"2023-11-06T13:39:30","slug":"reduction-du-ldl-c-a-long-terme-avec-levolocumab-resultats-de-fourier-ole","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/reduction-du-ldl-c-a-long-terme-avec-levolocumab-resultats-de-fourier-ole\/","title":{"rendered":"R\u00e9duction du LDL-C \u00e0 long terme avec l&#8217;\u00e9volocumab : r\u00e9sultats de FOURIER-OLE"},"content":{"rendered":"\n<p><strong>Avec la plus longue p\u00e9riode de suivi d&#8217;un inhibiteur de PCSK9 (PCSK9i) \u00e0 ce jour, les donn\u00e9es de l&#8217;extension en ouvert de l&#8217;\u00e9tude FOURIER (FOURIER-OLE) montrent qu&#8217;une r\u00e9duction \u00e0 long terme du LDL-C (<em><u>l<\/u>ow-<u>d<\/u>ensity <u>l<\/u>ipoprotein&nbsp;cholesterol<\/em>) avec l&#8217;\u00e9volocumab  en association avec un traitement par statines est bien tol\u00e9r\u00e9e pendant plus de 8 ans.<sup>1<\/sup>&nbsp;La forte r\u00e9duction du LDL-C d&#8217;environ 60% s&#8217;est maintenue de mani\u00e8re constante pendant toute la p\u00e9riode d&#8217;observation et aucun nouveau signal de s\u00e9curit\u00e9 n&#8217;a \u00e9t\u00e9 d\u00e9tect\u00e9.<sup>1<\/sup>&nbsp;De plus, dans une analyse exploratoire pr\u00e9d\u00e9finie, un d\u00e9but de traitement pr\u00e9coce a pu \u00eatre associ\u00e9 \u00e0 une r\u00e9duction plus importante du risque cardiovasculaire.<sup>1<\/sup>&nbsp;Les donn\u00e9es actuelles pr\u00e9conisent donc un d\u00e9but de traitement pr\u00e9coce avec l&#8217;\u00e9volocumab afin de maximiser les b\u00e9n\u00e9fices cliniques dans le cadre d&#8217;une utilisation \u00e0 long terme. En plus du principe &#8220;the lower the better&#8221;, &#8220;the earlier the better&#8221; s&#8217;applique donc \u00e9galement.<\/strong><\/p>\n\n\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/fr\/mon-compte\/paquets\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/fr\/se-connecter\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Ffr%2Freduction-du-ldl-c-a-long-terme-avec-levolocumab-resultats-de-fourier-ole%2F\">Connectez-vous ici<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Avec la plus longue p\u00e9riode de suivi d&#8217;un inhibiteur de PCSK9 (PCSK9i) \u00e0 ce jour, les donn\u00e9es de l&#8217;extension en ouvert de l&#8217;\u00e9tude FOURIER (FOURIER-OLE) montrent qu&#8217;une r\u00e9duction \u00e0 long&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/fr\/mon-compte\/paquets\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/fr\/se-connecter\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Ffr%2Freduction-du-ldl-c-a-long-terme-avec-levolocumab-resultats-de-fourier-ole%2F\">Connectez-vous ici<\/a><\/div><\/div><\/div>","protected":false},"author":17,"featured_media":367943,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"0","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"HYPERLIPID\u00c9MIE","footnotes":""},"category":[11549,11378,11345,11152,122,11249],"tags":[38336,12076],"powerkit_post_featured":[],"class_list":["post-367940","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-fr","category-cardiologie","category-contenu-des-partenaires","category-kardiologie","category-partner-content","category-rx","tag-cardiologie","tag-medecine-interne-generale","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-23 17:06:49","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"fr_FR","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/367940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/comments?post=367940"}],"version-history":[{"count":3,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/367940\/revisions"}],"predecessor-version":[{"id":369174,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/367940\/revisions\/369174"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media\/367943"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media?parent=367940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/category?post=367940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/tags?post=367940"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/powerkit_post_featured?post=367940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}