{"id":377933,"date":"2024-05-05T00:01:00","date_gmt":"2024-05-04T22:01:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=377933"},"modified":"2024-05-05T00:01:10","modified_gmt":"2024-05-04T22:01:10","slug":"une-meta-analyse-confirme-lefficacite-et-la-tolerance-de-lhypericum","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/une-meta-analyse-confirme-lefficacite-et-la-tolerance-de-lhypericum\/","title":{"rendered":"Une m\u00e9ta-analyse confirme l’efficacit\u00e9 et la tol\u00e9rance de l’Hypericum"},"content":{"rendered":"\n

Dans l’analyse secondaire publi\u00e9e l’ann\u00e9e derni\u00e8re dans la revue Advances in Clinical and Experimental Medicine <\/em>, les chercheurs ont compar\u00e9 les effets du millepertuis par rapport aux ISRS ou au placebo chez des adultes souffrant de troubles d\u00e9pressifs. Les donn\u00e9es utilis\u00e9es sont des \u00e9tudes contr\u00f4l\u00e9es issues de grandes bases de donn\u00e9es scientifiques, dans lesquelles l’\u00e9chelle de d\u00e9pression de Hamilton (HAM-D) a \u00e9t\u00e9 utilis\u00e9e. <\/strong><\/p>\n\n\n\n

La d\u00e9pression est le trouble mental le plus fr\u00e9quent, avec une pr\u00e9valence mondiale d’environ 3,8%. L’anh\u00e9donie est l’un des principaux sympt\u00f4mes, mais de nombreux autres peuvent appara\u00eetre, tels que les sautes d’humeur et l’anxi\u00e9t\u00e9. Parmi les m\u00e9thodes de traitement les plus r\u00e9pandues, outre les m\u00e9thodes psychoth\u00e9rapeutiques, on trouve l’utilisation d’inhibiteurs s\u00e9lectifs de la recapture de la s\u00e9rotonine (ISRS). Les pr\u00e9parations \u00e0 base de millepertuis (Hypericum perforatum)<\/em> sont consid\u00e9r\u00e9es comme une alternative aux ISRS pr\u00e9sentant peu d’effets secondaires.<\/p>\n

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Afin d’\u00e9valuer objectivement l’efficacit\u00e9 des pr\u00e9parations \u00e0 base d’Hypericum par rapport aux ISRS et au placebo, Zhao et al. a r\u00e9alis\u00e9 une m\u00e9ta-analyse [1]. Pour la recherche d’articles pertinents, les chercheurs ont utilis\u00e9 les bases de donn\u00e9es suivantes : Medline via PubMed ; Cinahl via EBSCO ; Scopus ; bases de donn\u00e9es Web of Sciences. Au total, 14 \u00e9tudes ont \u00e9t\u00e9 identifi\u00e9es, impliquant 2270 patients d\u00e9pressifs et r\u00e9pondant aux crit\u00e8res d’inclusion pr\u00e9d\u00e9finis**. [1\u201315] (tableau 1).<\/strong> La dur\u00e9e des \u00e9tudes incluses \u00e9tait de 6 semaines (7 \u00e9tudes), 8 semaines (4 \u00e9tudes), 12 semaines (2 \u00e9tudes) et 26 semaines (1 \u00e9tude). Dans 8 \u00e9tudes, la substance de r\u00e9f\u00e9rence \u00e9tait un ISRS (sertraline 4 \u00e9tudes, parox\u00e9tine 2 \u00e9tudes, fluox\u00e9tine 1 \u00e9tude, citalopram 1 \u00e9tude) et dans 6 \u00e9tudes, l’extrait de millepertuis \u00e9tait compar\u00e9 \u00e0 un placebo.<\/p>\n\n

** Les crit\u00e8res d’inclusion pr\u00e9d\u00e9finis concernaient la population de l’\u00e9tude, l’intervention, les bras de comparaison, les crit\u00e8res d’\u00e9valuation et le PICOS. <\/em><\/p>\n\n

Selon la m\u00e9ta-analyse, l’efficacit\u00e9 globale du traitement est en faveur du millepertuis. Le score HAM-D s’est am\u00e9lior\u00e9 davantage avec les ISRS (odds ratio group\u00e9 de 2,44 ; intervalle de confiance \u00e0 95% [KI] 1,33-4,45).<\/p>\n\n

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Litt\u00e9rature : <\/p>\n\n

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  1. Zhao X, et al : The efficacy and safety of St. John’s wort extract in depression therapy compared to SSRIs in adults : A meta-analysis of randomized clinical trials. Adv Clin Exp Med 2023 ; 32(2) : 151-161. <\/li>\n\n\n\n
  2. Lecrubier Y, et al. : Efficacit\u00e9 de l’extrait de parole de Saint-Jean WS 5570 dans la d\u00e9pression majeure : un essai en double aveugle, contr\u00f4l\u00e9 par placebo. Am J Psychiatry 2002 ; 159(8) : 1361-1366.<\/li>\n\n\n\n
  3. Van Gurp G, et al. : St John’s wort ou sertraline ? Randomized controlled trial in primary care. Can Fam Physician 2002 ; 48 : 905-912.<\/li>\n\n\n\n
  4. Hypericum Depression Trial Study Group. Effet de l’Hypericum perforatum (St John’s wort) dans les troubles d\u00e9pressifs majeurs : un essai randomis\u00e9 contr\u00f4l\u00e9. JAMA 2002 ; 287(14) : 1807.<\/li>\n\n\n\n
  5. Simeon J, et al. : Open-label pilot study of St. John’s wort in adolescent depression. J Child Adolesc Psychopharmacol 2005 ; 15(2) : 293-301. <\/li>\n\n\n\n
  6. Moreno RA, et al. : Hypericum perforatum versus fluoxetine dans le traitement de la d\u00e9pression l\u00e9g\u00e8re \u00e0 mod\u00e9r\u00e9e : un essai randomis\u00e9 en double aveugle dans un \u00e9chantillon br\u00e9silien. Rev Bras Psiquiatr 2006 ; 28(1) : 29-32. <\/li>\n\n\n\n
  7. Fava M, et al : A double-blind, randomized trial of St John’s wort, fluoxetine, and placebo in major depressive disorder. J Clin Psychopharmacol 2005 ; 25(5) : 441-447. <\/li>\n\n\n\n
  8. Bjerkenstedt L, et al : Hypericum extract LI 160 and fluoxetine in mild to moderate depression : A randomized, placebo- controlled multicenter study in outpatients. Eur Arch Psychiatry Clin Neurosci 2005 ; 255(1) : 40-47. <\/li>\n\n\n\n
  9. Szegedi A, et al. : Traitement aigu de la d\u00e9pression mod\u00e9r\u00e9e \u00e0 s\u00e9v\u00e8re avec l’extrait d’hypericum WS 5570 (St John’s wort) : Randomised controlled double blind non-inferiority trial versus paroxetine. BMJ 2005 ; 330(7490) : 503. <\/li>\n\n\n\n
  10. Kasper S, et al. : Superior efficacy of St John’s wort extract WS\u00ae5570 compared to placebo in patients with major depression : A randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]. BMC Med 2006 ; 4(1) : 14.<\/li>\n\n\n\n
  11. 11. Weber W, et al. : Hypericum perforatum (St John’s wort) for attentiondeficit\/hyperactivity disorder in children and adolescents : A randomized controlled trial. JAMA 2008 ; 299(22) : 2633.<\/li>\n\n\n\n
  12. Ur-Rahman R, et al. : Double blind placebo controlled clinical trial examining the effectiveness of St. John’s wort (Hypericum perforatum) in mild to moderate depression. J Pakistan Psychiatric Soc 2008 ; 5(2) : 106-111. <\/li>\n\n\n\n
  13. Singer A, et al : Duration of response after treatment of mild to moderate depression with Hypericum extract STW 3-VI, citalopram and placebo : A reanalysis of data from a controlled clinical trial. Phytomedicine 2011 ; 18(8-9) : 739-742.<\/li>\n\n\n\n
  14. Sarris J, et al. St John’s wort (Hypericum perforatum) versus sertraline and placebo in major depressive disorder : Continuation data from a 26-week RCT. Pharmacopsychiatrie. 2012 ; 45(07) : 275-278.<\/li>\n\n\n\n
  15. Seifritz E, Hatzinger M, Holsboer-Trachsler E : Efficacit\u00e9 de l’extrait d’Hypericum WS\u00ae5570 par rapport \u00e0 la parox\u00e9tine chez les patients pr\u00e9sentant un \u00e9pisode d\u00e9pressif majeur mod\u00e9r\u00e9 : une analyse de sous-groupe. Int J Psychiatry Clin Pract 2016 ; 20(3) : 126-132. <\/li>\n<\/ol>\n\n

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    PRATIQUE DU M\u00c9DECIN DE FAMILLE 2024 ; 19(4) : 50<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

    Dans l’analyse secondaire publi\u00e9e l’ann\u00e9e derni\u00e8re dans la revue Advances in Clinical and Experimental Medicine , les chercheurs ont compar\u00e9 les effets du millepertuis par rapport aux ISRS ou au…<\/p>\n","protected":false},"author":7,"featured_media":378212,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"D\u00e9pression l\u00e9g\u00e8re \u00e0 mod\u00e9r\u00e9e ","footnotes":""},"category":[11527,11315,11467,11489,11549],"tags":[14976,36664,18789,75250,75251],"powerkit_post_featured":[],"class_list":["post-377933","post","type-post","status-publish","format-standard","has-post-thumbnail","category-etudes","category-medecine-interne-generale","category-medecine-pharmaceutique","category-psychiatrie-et-psychotherapie","category-rx-fr","tag-depression-fr","tag-hypericum-perforatum-fr","tag-meta-analyse-fr","tag-preparations-a-base-de-millepertuis","tag-zhao-fr","pmpro-has-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-23 02:57:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"fr_FR","wpml_translations":{"it_IT":{"locale":"it_IT","id":377946,"slug":"una-meta-analisi-conferma-lefficacia-e-la-tollerabilita-delliperico","post_title":"Una meta-analisi conferma l'efficacia e la tollerabilit\u00e0 dell'Iperico","href":"https:\/\/medizinonline.com\/it\/una-meta-analisi-conferma-lefficacia-e-la-tollerabilita-delliperico\/"},"pt_PT":{"locale":"pt_PT","id":377956,"slug":"meta-analise-confirma-a-eficacia-e-a-tolerabilidade-do-hypericum","post_title":"Meta-an\u00e1lise confirma a efic\u00e1cia e a tolerabilidade do Hypericum","href":"https:\/\/medizinonline.com\/pt-pt\/meta-analise-confirma-a-eficacia-e-a-tolerabilidade-do-hypericum\/"},"es_ES":{"locale":"es_ES","id":377909,"slug":"un-metaanalisis-confirma-la-eficacia-y-tolerabilidad-del-hiperico","post_title":"Un metaan\u00e1lisis confirma la eficacia y tolerabilidad del hip\u00e9rico","href":"https:\/\/medizinonline.com\/es\/un-metaanalisis-confirma-la-eficacia-y-tolerabilidad-del-hiperico\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/377933","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/comments?post=377933"}],"version-history":[{"count":2,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/377933\/revisions"}],"predecessor-version":[{"id":378988,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/377933\/revisions\/378988"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media\/378212"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media?parent=377933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/category?post=377933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/tags?post=377933"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/powerkit_post_featured?post=377933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}