{"id":408373,"date":"2025-09-30T13:30:00","date_gmt":"2025-09-30T11:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=408373"},"modified":"2025-09-11T10:23:58","modified_gmt":"2025-09-11T08:23:58","slug":"edition-de-genes-intratumoraux-de-pd-l1-et-de-galectine-9-mediee-par-des-nanoparticules","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/edition-de-genes-intratumoraux-de-pd-l1-et-de-galectine-9-mediee-par-des-nanoparticules\/","title":{"rendered":"\u00c9dition de g\u00e8nes intratumoraux de PD-L1 et de galectine-9 m\u00e9di\u00e9e par des nanoparticules"},"content":{"rendered":"\n

Les inhibiteurs de points de contr\u00f4le immunitaires (ICI) ont r\u00e9volutionn\u00e9 le traitement oncologique, mais de nombreux patients ne r\u00e9pondent pas ou pas suffisamment \u00e0 cette forme de traitement. Les m\u00e9canismes de r\u00e9sistance, comme la surexpression de PD-L1 ou de mol\u00e9cules immunosuppressives comme la galectine-9, limitent leur efficacit\u00e9. Une nouvelle approche vise \u00e0 cibler l’\u00e9dition g\u00e9n\u00e9tique intratumorale \u00e0 l’aide de nanoparticules qui introduisent des composants CRISPR-Cas directement dans les cellules tumorales et y d\u00e9sactivent les g\u00e8nes r\u00e9gulateurs. Une \u00e9tude r\u00e9cente fournit des preuves pr\u00e9cliniques que l’\u00e9limination combin\u00e9e de PD-L1 et de la galectine-9 inhibe significativement la croissance tumorale et am\u00e9liore l’efficacit\u00e9 des th\u00e9rapies ICI. <\/strong><\/p>\n\n

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Les inhibiteurs de points de contr\u00f4le immunitaires (ICI) ont r\u00e9volutionn\u00e9 le traitement oncologique, mais de nombreux patients ne r\u00e9pondent pas ou pas suffisamment \u00e0 cette forme de traitement. Les m\u00e9canismes……... <\/p>\n

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