{"id":408724,"date":"2025-08-24T10:25:00","date_gmt":"2025-08-24T08:25:00","guid":{"rendered":"https:\/\/medizinonline.com\/auto-anticorps-anti-nephrine-dans-le-syndrome-nephrotique-resistant-aux-steroides\/"},"modified":"2025-09-12T11:18:56","modified_gmt":"2025-09-12T09:18:56","slug":"auto-anticorps-anti-nephrine-dans-le-syndrome-nephrotique-resistant-aux-steroides","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/auto-anticorps-anti-nephrine-dans-le-syndrome-nephrotique-resistant-aux-steroides\/","title":{"rendered":"Auto-anticorps anti-n\u00e9phrine dans le syndrome n\u00e9phrotique r\u00e9sistant aux st\u00e9ro\u00efdes"},"content":{"rendered":"\n

La compr\u00e9hension du syndrome n\u00e9phrotique idiopathique (SNI) est en pleine \u00e9volution. Alors que la majorit\u00e9 des enfants pr\u00e9sentant une forme sensible ou d\u00e9pendante des st\u00e9ro\u00efdes peuvent \u00eatre mis en r\u00e9mission par des glucocortico\u00efdes et une immunosuppression suppl\u00e9mentaire, la forme r\u00e9sistante aux st\u00e9ro\u00efdes reste un d\u00e9fi clinique. La d\u00e9couverte d’auto-anticorps dirig\u00e9s contre la prot\u00e9ine membranaire podocytaire \u00e0 fente, la n\u00e9phrine, ouvre un nouveau paradigme pathog\u00e9nique. Une grande \u00e9tude multicentrique montre maintenant que les auto-anticorps anti-n\u00e9phrine sont principalement pr\u00e9sents dans les formes sensibles et d\u00e9pendantes des st\u00e9ro\u00efdes, alors qu’ils sont largement absents dans les formes g\u00e9n\u00e9tiquement d\u00e9termin\u00e9es ou multi-r\u00e9sistantes aux m\u00e9dicaments. Cela sugg\u00e8re que les anticorps anti-n\u00e9phrine ne refl\u00e8tent pas seulement la pathogen\u00e8se et le pronostic, mais pourraient \u00e9galement orienter les d\u00e9cisions th\u00e9rapeutiques. <\/strong><\/p>\n\n

Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich
Jetzt beitreten<\/a><\/div>
Already a member? Connectez-vous ici<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

La compr\u00e9hension du syndrome n\u00e9phrotique idiopathique (SNI) est en pleine \u00e9volution. Alors que la majorit\u00e9 des enfants pr\u00e9sentant une forme sensible ou d\u00e9pendante des st\u00e9ro\u00efdes peuvent \u00eatre mis en r\u00e9mission……... <\/p>\n

Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich
Jetzt beitreten<\/a><\/div>
Already a member? Connectez-vous ici<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":408726,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Biomarqueurs, m\u00e9canisme pathologique et implications th\u00e9rapeutiques ","footnotes":""},"category":[11527,11531,11434,11458,11549],"tags":[85296,85297,63958],"powerkit_post_featured":[],"class_list":["post-408724","post","type-post","status-publish","format-standard","has-post-thumbnail","category-etudes","category-formation-continue","category-nephrologie-fr","category-pediatrie","category-rx-fr","tag-auto-anticorps-anti-nephrine","tag-srns-fr","tag-syndrome-nephrotique","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-03 01:43:57","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"fr_FR","wpml_translations":{"it_IT":{"locale":"it_IT","id":408718,"slug":"autoanticorpi-anti-nefrina-nella-sindrome-nefrosica-steroido-resistente","post_title":"Autoanticorpi anti-nefrina nella sindrome nefrosica steroido-resistente","href":"https:\/\/medizinonline.com\/it\/autoanticorpi-anti-nefrina-nella-sindrome-nefrosica-steroido-resistente\/"},"pt_PT":{"locale":"pt_PT","id":408712,"slug":"autoanticorpos-anti-nefrina-na-sindrome-nefrotica-resistente-a-esteroides","post_title":"Autoanticorpos anti-nefrina na s\u00edndrome nefr\u00f3tica resistente a ester\u00f3ides","href":"https:\/\/medizinonline.com\/pt-pt\/autoanticorpos-anti-nefrina-na-sindrome-nefrotica-resistente-a-esteroides\/"},"es_ES":{"locale":"es_ES","id":408706,"slug":"autoanticuerpos-antinefrina-en-el-sindrome-nefrotico-resistente-a-esteroides","post_title":"Autoanticuerpos antinefrina en el s\u00edndrome nefr\u00f3tico resistente a esteroides","href":"https:\/\/medizinonline.com\/es\/autoanticuerpos-antinefrina-en-el-sindrome-nefrotico-resistente-a-esteroides\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/408724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/comments?post=408724"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/408724\/revisions"}],"predecessor-version":[{"id":408727,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/408724\/revisions\/408727"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media\/408726"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media?parent=408724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/category?post=408724"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/tags?post=408724"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/powerkit_post_featured?post=408724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}