{"id":411800,"date":"2025-11-25T13:30:00","date_gmt":"2025-11-25T12:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=411800"},"modified":"2025-11-03T12:03:03","modified_gmt":"2025-11-03T11:03:03","slug":"enpp1-comme-biomarqueur-de-mauvais-pronostic-et-de-detection-precoce-des-metastases-cerebrales","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/enpp1-comme-biomarqueur-de-mauvais-pronostic-et-de-detection-precoce-des-metastases-cerebrales\/","title":{"rendered":"ENPP1 comme biomarqueur de mauvais pronostic et de d\u00e9tection pr\u00e9coce des m\u00e9tastases c\u00e9r\u00e9brales"},"content":{"rendered":"\n

Environ 15 \u00e0 20% de tous les cancers du sein sont HER2-positifs, un sous-type qui se caract\u00e9rise par une \u00e9volution agressive et une tendance accrue \u00e0 la m\u00e9tastase c\u00e9r\u00e9brale. Une nouvelle \u00e9tude montre maintenant que l’enzyme ENPP1 mine la fonction de barri\u00e8re de la barri\u00e8re h\u00e9mato-enc\u00e9phalique (BHS) et peut servir de biomarqueur potentiel pour la phase pr\u00e9coce de d\u00e9veloppement de m\u00e9tastases c\u00e9r\u00e9brales dans le cancer du sein HER2-positif, de sorte que les inhibiteurs de l’ENPP1<\/em>pourront \u00eatre utilis\u00e9s \u00e0 l’avenir comme strat\u00e9gie compl\u00e9mentaire de pr\u00e9vention des m\u00e9tastases, surtout chez les patientes pr\u00e9sentant une expression \u00e9lev\u00e9e de l’ENPP1 et un dysfonctionnement av\u00e9r\u00e9 de la BHS. <\/strong><\/p>\n\n

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Environ 15 \u00e0 20% de tous les cancers du sein sont HER2-positifs, un sous-type qui se caract\u00e9rise par une \u00e9volution agressive et une tendance accrue \u00e0 la m\u00e9tastase c\u00e9r\u00e9brale. Une……... <\/p>\n

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