{"id":552480,"date":"2026-04-13T16:39:50","date_gmt":"2026-04-13T14:39:50","guid":{"rendered":"https:\/\/medizinonline.com\/?p=552480"},"modified":"2026-04-13T16:39:56","modified_gmt":"2026-04-13T14:39:56","slug":"dupilumab-traitement-de-la-polypose-naso-sinusienne-severe-avancee-majeure","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/dupilumab-traitement-de-la-polypose-naso-sinusienne-severe-avancee-majeure\/","title":{"rendered":"Dupilumab, traitement de la polypose naso-sinusienne s\u00e9v\u00e8re : avanc\u00e9e majeure"},"content":{"rendered":"\n<p><strong>La polypose naso-sinusienne (PNS), \u00e9galement connue sous le terme de rhinosinusite chronique avec polypes nasaux, est une maladie inflammatoire invalidante affectant la qualit\u00e9 de vie des patients, souvent associ\u00e9e \u00e0 des comorbidit\u00e9s comme l\u2019asthme ou l\u2019intol\u00e9rance aux anti-inflammatoires non st\u00e9ro\u00efdiens (AINS-ERD). Chez jusqu\u2019\u00e0 80% des patients, la PNS est <br>provoqu\u00e9e par une inflammation de type 2, caract\u00e9ris\u00e9e par l\u2019action des interleukines IL-4 et IL-13, qui favorisent la formation de polypes et les r\u00e9cidives<sup>1,2,3<\/sup>. Le dupilumab,  premier m\u00e9dicament biologique approuv\u00e9 pour le traitement de la PNS s\u00e9v\u00e8re, cible pr\u00e9cis\u00e9ment cette inflammation, r\u00e9volutionnant ainsi le traitement de cette maladie<strong><sup>1,2<\/sup><\/strong>. Cet article synth\u00e9tise les donn\u00e9es provenant d&#8217;\u00e9tudes en conditions r\u00e9elles (Real World Evidence, RWE), notamment DUPIREAL et ProGNOSE, pour d\u00e9montrer l\u2019efficacit\u00e9 et la s\u00e9curit\u00e9 du dupilumab<strong><sup>1,2<\/sup><\/strong>, offrant aux professionnels de sant\u00e9 des preuves solides pour un usage s\u00fbr et fiable. | Adeline Beijns<\/strong><\/p>\n\n\n\n<p><strong>Donn\u00e9es en vie r\u00e9elle : confirmation des b\u00e9n\u00e9fices du dupilumab<\/strong><\/p>\n\n\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/fr\/mon-compte\/paquets\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/fr\/se-connecter\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Ffr%2Fdupilumab-traitement-de-la-polypose-naso-sinusienne-severe-avancee-majeure%2F\">Connectez-vous ici<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>La polypose naso-sinusienne (PNS), \u00e9galement connue sous le terme de rhinosinusite chronique avec polypes nasaux, est une maladie inflammatoire invalidante affectant la qualit\u00e9 de vie des patients, souvent associ\u00e9e \u00e0&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/fr\/mon-compte\/paquets\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/fr\/se-connecter\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Ffr%2Fdupilumab-traitement-de-la-polypose-naso-sinusienne-severe-avancee-majeure%2F\">Connectez-vous ici<\/a><\/div><\/div><\/div>","protected":false},"author":17461,"featured_media":552489,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Contenu sponsoris\u00e9","footnotes":""},"category":[11549,11448,11477],"tags":[],"powerkit_post_featured":[],"class_list":["post-552480","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-fr","category-orl-fr","category-pneumologie-fr","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-20 22:11:34","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"fr_FR","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/552480","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/users\/17461"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/comments?post=552480"}],"version-history":[{"count":3,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/552480\/revisions"}],"predecessor-version":[{"id":553015,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/552480\/revisions\/553015"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media\/552489"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media?parent=552480"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/category?post=552480"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/tags?post=552480"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/powerkit_post_featured?post=552480"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}