{"id":557075,"date":"2026-05-05T22:00:00","date_gmt":"2026-05-05T20:00:00","guid":{"rendered":"https:\/\/medizinonline.com\/approche-top-down-ou-therapie-classique-par-etapes\/"},"modified":"2026-05-18T13:22:44","modified_gmt":"2026-05-18T11:22:44","slug":"approche-top-down-ou-therapie-classique-par-etapes","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/approche-top-down-ou-therapie-classique-par-etapes\/","title":{"rendered":"Approche &#8220;top-down&#8221; ou th\u00e9rapie classique par \u00e9tapes ?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Par d\u00e9faut, le traitement de la maladie de Crohn (M. Crohn) est ax\u00e9 sur la strat\u00e9gie &#8220;step-up&#8221;. Les r\u00e9sultats de l&#8217;\u00e9tude PROFILE indiquent cependant que, dans la maladie de Crohn nouvellement diagnostiqu\u00e9e, l&#8217;utilisation pr\u00e9coce d&#8217;un inhibiteur du TNF-\u03b1 associ\u00e9 \u00e0 un immunomodulateur est significativement plus efficace qu&#8217;une escalade par \u00e9tapes. Les r\u00e9sultats du suivi sur plusieurs ann\u00e9es, publi\u00e9s r\u00e9cemment, montrent que cela est \u00e9galement vrai pour les r\u00e9sultats \u00e0 plus long terme. Aussi int\u00e9ressants que soient les r\u00e9sultats de ces \u00e9tudes, la ligne directrice conseille, dans le cadre d&#8217;une approche de &#8220;meilleure pratique&#8221;, d&#8217;\u00e9valuer individuellement l&#8217;\u00e9volution du traitement \u00e0 l&#8217;aide de param\u00e8tres de substitution et de l&#8217;adapter en cons\u00e9quence en fonction de la r\u00e9ponse.   <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/fr\/mon-compte\/paquets\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/fr\/se-connecter\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Ffr%2Fapproche-top-down-ou-therapie-classique-par-etapes%2F\">Connectez-vous ici<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Par d\u00e9faut, le traitement de la maladie de Crohn (M. Crohn) est ax\u00e9 sur la strat\u00e9gie &#8220;step-up&#8221;. Les r\u00e9sultats de l&#8217;\u00e9tude PROFILE indiquent cependant que, dans la maladie de Crohn&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/fr\/mon-compte\/paquets\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/fr\/se-connecter\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Ffr%2Fapproche-top-down-ou-therapie-classique-par-etapes%2F\">Connectez-vous ici<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":557076,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Maladie de Crohn : attention aux r\u00e9sultats \u00e0 long terme","footnotes":""},"category":[11549,11527,11414,11315,11535],"tags":[93999,16021,37534,24339,62489,15758,73189,93998,93997,28641],"powerkit_post_featured":[],"class_list":["post-557075","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-fr","category-etudes","category-gastro-enterologie-et-hepatologie","category-medecine-interne-generale","category-rapports-de-congres","tag-approche-des-meilleures-pratiques","tag-ced-fr","tag-escalade","tag-immunomodulateur","tag-inhibiteur-du-tnf-","tag-maladie-de-crohn","tag-outcomes-fr","tag-profils","tag-resultats-a-long-terme","tag-therapie-par-etapes","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-27 04:33:59","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"fr_FR","wpml_translations":{"it_IT":{"locale":"it_IT","id":557072,"slug":"approccio-top-down-o-terapia-a-tappe-classica","post_title":"Approccio \"top-down\" o terapia a tappe classica?","href":"https:\/\/medizinonline.com\/it\/approccio-top-down-o-terapia-a-tappe-classica\/"},"pt_PT":{"locale":"pt_PT","id":557069,"slug":"abordagem-top-down-ou-terapia-por-etapas-classica","post_title":"Abordagem \"top-down\" ou terapia por etapas cl\u00e1ssica?","href":"https:\/\/medizinonline.com\/pt-pt\/abordagem-top-down-ou-terapia-por-etapas-classica\/"},"es_ES":{"locale":"es_ES","id":557066,"slug":"enfoque-descendente-o-terapia-escalonada-clasica","post_title":"\u00bfEnfoque \"descendente\" o terapia escalonada cl\u00e1sica?","href":"https:\/\/medizinonline.com\/es\/enfoque-descendente-o-terapia-escalonada-clasica\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/557075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/comments?post=557075"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/557075\/revisions"}],"predecessor-version":[{"id":557077,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/557075\/revisions\/557077"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media\/557076"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media?parent=557075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/category?post=557075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/tags?post=557075"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/powerkit_post_featured?post=557075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}