{"id":557180,"date":"2026-06-06T12:42:24","date_gmt":"2026-06-06T10:42:24","guid":{"rendered":"https:\/\/medizinonline.com\/stabilisateurs-ttr-mise-sous-silence-des-genes-et-ciseaux-genetiques-ou-en-sommes-nous\/"},"modified":"2026-06-06T12:42:33","modified_gmt":"2026-06-06T10:42:33","slug":"stabilisateurs-ttr-mise-sous-silence-des-genes-et-ciseaux-genetiques-ou-en-sommes-nous","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/stabilisateurs-ttr-mise-sous-silence-des-genes-et-ciseaux-genetiques-ou-en-sommes-nous\/","title":{"rendered":"Stabilisateurs TTR, mise sous silence des g\u00e8nes et ciseaux g\u00e9n\u00e9tiques : o\u00f9 en sommes-nous ?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Les progr\u00e8s dans la compr\u00e9hension de la physiopathologie de la cardiomyopathie amylo\u00efde \u00e0 transthyr\u00e9tine (ATTR-CM) ont r\u00e9volutionn\u00e9 le paysage th\u00e9rapeutique au cours des derni\u00e8res ann\u00e9es. Les stabilisateurs de TTR comme le tafamidis et l&#8217;acoramidis peuvent r\u00e9duire l&#8217;instabilit\u00e9 de la TTR et la formation subs\u00e9quente de fibrilles amylo\u00efdes, et les th\u00e9rapies de silencing g\u00e9nique utilisant des ARN &#8220;small interfering&#8221; comme le patisiran et le putrisiran ou des inhibiteurs d&#8217;oligonucl\u00e9otides antisens comme l&#8217;inotersen et l&#8217;\u00e9plontersen constituent \u00e9galement des options th\u00e9rapeutiques prometteuses en r\u00e9duisant la production de TTR. Des \u00e9tudes en cours explorent d&#8217;autres silencers de g\u00e8nes, ainsi que des th\u00e9rapies g\u00e9niques et des strat\u00e9gies de traitement combin\u00e9es.    <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/fr\/mon-compte\/paquets\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/fr\/se-connecter\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Ffr%2Fstabilisateurs-ttr-mise-sous-silence-des-genes-et-ciseaux-genetiques-ou-en-sommes-nous%2F\">Connectez-vous ici<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Les progr\u00e8s dans la compr\u00e9hension de la physiopathologie de la cardiomyopathie amylo\u00efde \u00e0 transthyr\u00e9tine (ATTR-CM) ont r\u00e9volutionn\u00e9 le paysage th\u00e9rapeutique au cours des derni\u00e8res ann\u00e9es. Les stabilisateurs de TTR comme&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/fr\/mon-compte\/paquets\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/fr\/se-connecter\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Ffr%2Fstabilisateurs-ttr-mise-sous-silence-des-genes-et-ciseaux-genetiques-ou-en-sommes-nous%2F\">Connectez-vous ici<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":557181,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Traitements modificateurs de la maladie ATTR-CM","footnotes":""},"category":[11549,11378,11527,11417,11535],"tags":[93744,94135,94137,74844,94134,74842,94136,94139,74846],"powerkit_post_featured":[],"class_list":["post-557180","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-fr","category-cardiologie","category-etudes","category-genetique","category-rapports-de-congres","tag-attr-cm","tag-ciseaux-genetiques","tag-inhibiteurs-doligonucleotides-antisens","tag-inotersen","tag-mise-sous-silence-des-genes","tag-patisiran","tag-stabilisateurs-ttr","tag-therapies-de-modification-de-la-maladie","tag-vutrisiran","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-07-04 18:46:11","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"fr_FR","wpml_translations":{"it_IT":{"locale":"it_IT","id":557177,"slug":"stabilizzatori-ttr-silenziamento-genico-e-forbici-geniche-a-che-punto-siamo","post_title":"Stabilizzatori TTR, silenziamento genico e forbici geniche: a che punto siamo?","href":"https:\/\/medizinonline.com\/it\/stabilizzatori-ttr-silenziamento-genico-e-forbici-geniche-a-che-punto-siamo\/"},"pt_PT":{"locale":"pt_PT","id":557174,"slug":"estabilizadores-de-ttr-silenciamento-de-genes-e-tesouras-de-genes-em-que-ponto-estamos","post_title":"Estabilizadores de TTR, silenciamento de genes e tesouras de genes: em que ponto estamos?","href":"https:\/\/medizinonline.com\/pt-pt\/estabilizadores-de-ttr-silenciamento-de-genes-e-tesouras-de-genes-em-que-ponto-estamos\/"},"es_ES":{"locale":"es_ES","id":557171,"slug":"estabilizadores-de-la-ttr-silenciamiento-y-tijeras-geneticas-en-que-punto-nos-encontramos","post_title":"Estabilizadores de la TTR, silenciamiento y tijeras gen\u00e9ticas: \u00bfen qu\u00e9 punto nos encontramos?","href":"https:\/\/medizinonline.com\/es\/estabilizadores-de-la-ttr-silenciamiento-y-tijeras-geneticas-en-que-punto-nos-encontramos\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/557180","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/comments?post=557180"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/557180\/revisions"}],"predecessor-version":[{"id":557182,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/posts\/557180\/revisions\/557182"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media\/557181"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/media?parent=557180"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/category?post=557180"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/tags?post=557180"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/fr\/wp-json\/wp\/v2\/powerkit_post_featured?post=557180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}