{"id":560793,"date":"2026-08-10T21:57:33","date_gmt":"2026-08-10T19:57:33","guid":{"rendered":"https:\/\/medizinonline.com\/?p=560793"},"modified":"2026-08-10T21:57:41","modified_gmt":"2026-08-10T19:57:41","slug":"la-revolution-des-incretines-en-cardiologie","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/fr\/la-revolution-des-incretines-en-cardiologie\/","title":{"rendered":"La r\u00e9volution des incr\u00e9tines en cardiologie"},"content":{"rendered":"\n

En l’espace d’une d\u00e9cennie, les mim\u00e9tiques des incr\u00e9tines sont pass\u00e9s du statut de m\u00e9dicaments hypoglyc\u00e9miants destin\u00e9s au traitement du diab\u00e8te \u00e0 celui de l’une des classes de principes actifs les plus dynamiques de la m\u00e9decine cardiovasculaire. Il a \u00e9t\u00e9 d\u00e9montr\u00e9 que les agonistes des r\u00e9cepteurs du GLP-1 (GLP-1-RA) r\u00e9duisent de mani\u00e8re av\u00e9r\u00e9e le risque d\u2019\u00e9v\u00e9nements cardiovasculaires majeurs (MACE) et d\u2019hospitalisations pour insuffisance cardiaque, diminuent l\u2019albuminurie et ralentissent la baisse du DFG estim\u00e9 \u2013 et ce, de plus en plus au-del\u00e0 du seul contexte du diab\u00e8te. Avec le s\u00e9maglutide oral, c\u2019est la premi\u00e8re fois qu\u2019un m\u00e9dicament administr\u00e9 par voie orale, dont les b\u00e9n\u00e9fices cardiovasculaires sont av\u00e9r\u00e9s, fait son apparition, accompagn\u00e9 d\u2019une premi\u00e8re base de donn\u00e9es importante sur l\u2019insuffisance cardiaque dans le diab\u00e8te de type 2. Et la prochaine g\u00e9n\u00e9ration se profile d\u00e9j\u00e0 \u00e0 l\u2019horizon avec les triples agonistes tels que le r\u00e9tatrutide. <\/strong><\/p>\n\n

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En l’espace d’une d\u00e9cennie, les mim\u00e9tiques des incr\u00e9tines sont pass\u00e9s du statut de m\u00e9dicaments hypoglyc\u00e9miants destin\u00e9s au traitement du diab\u00e8te \u00e0 celui de l’une des classes de principes actifs les……... <\/p>\n

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