{"id":408712,"date":"2025-08-24T10:25:00","date_gmt":"2025-08-24T08:25:00","guid":{"rendered":"https:\/\/medizinonline.com\/autoanticorpos-anti-nefrina-na-sindrome-nefrotica-resistente-a-esteroides\/"},"modified":"2025-09-12T11:18:55","modified_gmt":"2025-09-12T09:18:55","slug":"autoanticorpos-anti-nefrina-na-sindrome-nefrotica-resistente-a-esteroides","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/pt-pt\/autoanticorpos-anti-nefrina-na-sindrome-nefrotica-resistente-a-esteroides\/","title":{"rendered":"Autoanticorpos anti-nefrina na s\u00edndrome nefr\u00f3tica resistente a ester\u00f3ides"},"content":{"rendered":"\n<p><strong>A compreens\u00e3o da s\u00edndrome nefr\u00f3tica idiop\u00e1tica (SNI) est\u00e1 num estado de fluxo. Embora a maioria das crian\u00e7as com uma evolu\u00e7\u00e3o sens\u00edvel ou dependente de ester\u00f3ides possa entrar em remiss\u00e3o com glucocortic\u00f3ides e imunossupress\u00e3o adicional, a forma resistente aos ester\u00f3ides continua a ser um desafio cl\u00ednico. A descoberta de auto-anticorpos contra a prote\u00edna nefrina do diafragma da fenda podoc\u00edtica abre um novo paradigma patog\u00e9nico. Um grande estudo multic\u00eantrico mostra agora que os auto-anticorpos anti-nefrina s\u00e3o encontrados principalmente nas formas sens\u00edveis e dependentes de ester\u00f3ides, enquanto est\u00e3o ausentes nas formas geneticamente determinadas ou resistentes a v\u00e1rios medicamentos. Isto sugere que os anticorpos anti-nefrina n\u00e3o s\u00f3 reflectem a patog\u00e9nese e o progn\u00f3stico, como tamb\u00e9m podem orientar as decis\u00f5es terap\u00eauticas.    <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/pt-pt\/a-minha-conta\/pacotes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/pt-pt\/iniciar-sessao\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fpt-pt%2Fautoanticorpos-anti-nefrina-na-sindrome-nefrotica-resistente-a-esteroides%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>A compreens\u00e3o da s\u00edndrome nefr\u00f3tica idiop\u00e1tica (SNI) est\u00e1 num estado de fluxo. Embora a maioria das crian\u00e7as com uma evolu\u00e7\u00e3o sens\u00edvel ou dependente de ester\u00f3ides possa entrar em remiss\u00e3o com&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/pt-pt\/a-minha-conta\/pacotes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/pt-pt\/iniciar-sessao\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fpt-pt%2Fautoanticorpos-anti-nefrina-na-sindrome-nefrotica-resistente-a-esteroides%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":408714,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Biomarcadores, mecanismos patog\u00e9nicos e implica\u00e7\u00f5es terap\u00eauticas  ","footnotes":""},"category":[11521,11524,11426,11450,11551],"tags":[85288,64002,85289],"powerkit_post_featured":[],"class_list":["post-408712","post","type-post","status-publish","format-standard","has-post-thumbnail","category-estudos","category-formacao-continua","category-nefrologia-pt-pt","category-pediatria-pt-pt","category-rx-pt","tag-auto-anticorpos-anti-nefrina","tag-sindrome-nefrotica","tag-srns-pt-pt","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-30 05:58:45","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"pt_PT","wpml_translations":{"es_ES":{"locale":"es_ES","id":408706,"slug":"autoanticuerpos-antinefrina-en-el-sindrome-nefrotico-resistente-a-esteroides","post_title":"Autoanticuerpos antinefrina en el s\u00edndrome nefr\u00f3tico resistente a esteroides","href":"https:\/\/medizinonline.com\/es\/autoanticuerpos-antinefrina-en-el-sindrome-nefrotico-resistente-a-esteroides\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/408712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/comments?post=408712"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/408712\/revisions"}],"predecessor-version":[{"id":408716,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/408712\/revisions\/408716"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/media\/408714"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/media?parent=408712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/category?post=408712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/tags?post=408712"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/powerkit_post_featured?post=408712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}