{"id":459472,"date":"2025-12-31T13:30:00","date_gmt":"2025-12-31T12:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=459472"},"modified":"2025-12-31T14:36:56","modified_gmt":"2025-12-31T13:36:56","slug":"agonistas-dos-receptores-glp-1-em-cardiologia","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/pt-pt\/agonistas-dos-receptores-glp-1-em-cardiologia\/","title":{"rendered":"Agonistas dos receptores GLP-1 em cardiologia"},"content":{"rendered":"\n<p><strong>Os agonistas dos receptores GLP-1 (GLP-1RA) evolu\u00edram rapidamente de f\u00e1rmacos antidiab\u00e9ticos para terapias cardiometab\u00f3licas com redu\u00e7\u00f5es clinicamente comprovadas em par\u00e2metros cardiovasculares dif\u00edceis &#8211; e cada vez mais para al\u00e9m da popula\u00e7\u00e3o tradicional com diabetes. A base mecanicista vai desde efeitos anti-aterog\u00e9nicos e protectores do endot\u00e9lio a mecanismos anti-inflamat\u00f3rios e de prote\u00e7\u00e3o card\u00edaca direta, passando por uma redu\u00e7\u00e3o substancial do peso com altera\u00e7\u00f5es favor\u00e1veis da press\u00e3o arterial e dos l\u00edpidos. O artigo que se segue introduz os princ\u00edpios fisiol\u00f3gicos, categoriza criticamente a evid\u00eancia dos resultados e discute o liraglutido, o semaglutido (s.c. e oral), o dulaglutido, o albiglutido, o efpeglenatido, o exenatido e o lixisenatido numa base espec\u00edfica para cada subst\u00e2ncia. Os conceitos de incretinas duplas e triplas s\u00e3o descritos em perspetiva. Finalmente, s\u00e3o discutidas a seguran\u00e7a, a implementa\u00e7\u00e3o e as quest\u00f5es em aberto para a pr\u00e1tica.    <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/pt-pt\/a-minha-conta\/pacotes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/pt-pt\/iniciar-sessao\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fpt-pt%2Fagonistas-dos-receptores-glp-1-em-cardiologia%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Os agonistas dos receptores GLP-1 (GLP-1RA) evolu\u00edram rapidamente de f\u00e1rmacos antidiab\u00e9ticos para terapias cardiometab\u00f3licas com redu\u00e7\u00f5es clinicamente comprovadas em par\u00e2metros cardiovasculares dif\u00edceis &#8211; e cada vez mais para al\u00e9m da&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/pt-pt\/a-minha-conta\/pacotes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/pt-pt\/iniciar-sessao\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fpt-pt%2Fagonistas-dos-receptores-glp-1-em-cardiologia%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":459473,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Mecanismos, provas e consequ\u00eancias terap\u00eauticas  ","footnotes":""},"category":[11367,11397,11521,11524,11551],"tags":[87461,19681,87460,87462,18634,81307,25483],"powerkit_post_featured":[],"class_list":["post-459472","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cardiologia-pt-pt","category-endocrinologia-e-diabetologia-2","category-estudos","category-formacao-continua","category-rx-pt","tag-albiglutide","tag-bpl-1","tag-efeitos-cardiacos","tag-efpeglenatido","tag-liraglutide-pt-pt","tag-lixisenatido","tag-mace-pt-pt","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-30 07:41:36","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"pt_PT","wpml_translations":{"es_ES":{"locale":"es_ES","id":459463,"slug":"agonistas-del-receptor-glp-1-en-cardiologia","post_title":"Agonistas del receptor GLP-1 en cardiolog\u00eda","href":"https:\/\/medizinonline.com\/es\/agonistas-del-receptor-glp-1-en-cardiologia\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/459472","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/comments?post=459472"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/459472\/revisions"}],"predecessor-version":[{"id":459474,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/459472\/revisions\/459474"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/media\/459473"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/media?parent=459472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/category?post=459472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/tags?post=459472"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/powerkit_post_featured?post=459472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}