{"id":460639,"date":"2026-02-06T11:52:46","date_gmt":"2026-02-06T10:52:46","guid":{"rendered":"https:\/\/medizinonline.com\/senescencia-celular\/"},"modified":"2026-02-06T11:52:53","modified_gmt":"2026-02-06T10:52:53","slug":"senescencia-celular","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/pt-pt\/senescencia-celular\/","title":{"rendered":"Senesc\u00eancia celular"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>A senesc\u00eancia celular \u00e9 considerada um programa biol\u00f3gico fundamental que pode exercer tanto efeitos protectores como potencialmente patog\u00e9nicos nos tecidos ao longo da vida. Se as c\u00e9lulas senescentes persistirem, est\u00e3o associadas a uma inflama\u00e7\u00e3o cr\u00f3nica, a uma perturba\u00e7\u00e3o da homeostase dos tecidos e a diversos fen\u00f3tipos de doen\u00e7a. Nos \u00faltimos anos, surgiu um campo de investiga\u00e7\u00e3o clinicamente muito relevante: As senoterapias &#8211; em particular as senol\u00edticas (elimina\u00e7\u00e3o selectiva de c\u00e9lulas senescentes) e as senom\u00f3rficas (modula\u00e7\u00e3o dos padr\u00f5es de sinaliza\u00e7\u00e3o e secre\u00e7\u00e3o associados \u00e0 senesc\u00eancia) &#8211; s\u00e3o amplamente investigadas em modelos pr\u00e9-cl\u00ednicos, enquanto as provas em seres humanos prov\u00eam, at\u00e9 \u00e0 data, sobretudo de pequenos estudos iniciais ou de conjuntos de dados cl\u00ednicos indirectos.  <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/pt-pt\/a-minha-conta\/pacotes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/pt-pt\/iniciar-sessao\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fpt-pt%2Fsenescencia-celular%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>A senesc\u00eancia celular \u00e9 considerada um programa biol\u00f3gico fundamental que pode exercer tanto efeitos protectores como potencialmente patog\u00e9nicos nos tecidos ao longo da vida. Se as c\u00e9lulas senescentes persistirem, est\u00e3o&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/pt-pt\/a-minha-conta\/pacotes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/pt-pt\/iniciar-sessao\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fpt-pt%2Fsenescencia-celular%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":460640,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Foco em novos alvos terap\u00eauticos e senol\u00edticos  ","footnotes":"","_members_access_role":[],"_members_access_error":""},"category":[11551,11521,11524,11411,11360,11305,11474],"tags":[88074,88073],"powerkit_post_featured":[],"class_list":["post-460639","post","type-post","status-publish","format-standard","has-post-thumbnail","category-rx-pt","category-estudos","category-formacao-continua","category-genetica-pt-pt","category-geriatria-pt-pt","category-medicina-interna-geral","category-prevencao-e-cuidados-de-saude","tag-encurtamento-dos-telomeros","tag-senomorficos","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-08-09 07:49:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"pt_PT","wpml_translations":{"es_ES":{"locale":"es_ES","id":460636,"slug":"senescencia-celular","post_title":"Senescencia celular","href":"https:\/\/medizinonline.com\/es\/senescencia-celular\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/460639","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/comments?post=460639"}],"version-history":[{"count":2,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/460639\/revisions"}],"predecessor-version":[{"id":460656,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/460639\/revisions\/460656"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/media\/460640"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/media?parent=460639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/category?post=460639"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/tags?post=460639"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/powerkit_post_featured?post=460639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}