{"id":551246,"date":"2026-03-09T00:30:00","date_gmt":"2026-03-08T23:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=551246"},"modified":"2026-03-02T09:59:52","modified_gmt":"2026-03-02T08:59:52","slug":"mecanismos-moleculares-da-plasticidade-tumoral","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/pt-pt\/mecanismos-moleculares-da-plasticidade-tumoral\/","title":{"rendered":"Mecanismos moleculares da plasticidade tumoral"},"content":{"rendered":"\n<p><strong>A plasticidade tumoral, a reprograma\u00e7\u00e3o epigen\u00e9tica e o microambiente tumoral din\u00e2mico moldam a biologia do CCR, da LMA e do melanoma e influenciam a sua vulnerabilidade terap\u00eautica. As abordagens terap\u00eauticas modernas combinam perfis moleculares, assinaturas TME e biomarcadores funcionais para ultrapassar os programas de resist\u00eancia e permitir terapias mais precisas e espec\u00edficas para cada doente. <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/pt-pt\/a-minha-conta\/pacotes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/pt-pt\/iniciar-sessao\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fpt-pt%2Fmecanismos-moleculares-da-plasticidade-tumoral%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>A plasticidade tumoral, a reprograma\u00e7\u00e3o epigen\u00e9tica e o microambiente tumoral din\u00e2mico moldam a biologia do CCR, da LMA e do melanoma e influenciam a sua vulnerabilidade terap\u00eautica. As abordagens terap\u00eauticas&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/pt-pt\/a-minha-conta\/pacotes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/pt-pt\/iniciar-sessao\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fpt-pt%2Fmecanismos-moleculares-da-plasticidade-tumoral%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":551254,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"CRC, AML e melanoma em foco","footnotes":""},"category":[11356,11521,22618,11411,11365,11379,11551],"tags":[89873,22965,89926,89885,89902,45301,89868,89883,89923,89915,89890,89893,89904,89906,89894,89897,78310,12485,89879,22372,89918,89910,89900,89899,89864,89876,89889,89887,89869,89921,89913,89929,89909],"powerkit_post_featured":[],"class_list":["post-551246","post","type-post","status-publish","format-standard","has-post-thumbnail","category-dermatologia-e-venereologia-pt-pt","category-estudos","category-formacao-cme","category-genetica-pt-pt","category-hematologia-pt-pt","category-oncologia-pt-pt","category-rx-pt","tag-acoplamento-metabolico-epigenetico","tag-aml-pt-pt","tag-assinaturas-de-ifn-","tag-ativacao-nf-b","tag-biomarcadores-funcionais","tag-crc-pt-pt","tag-dinamica-tme","tag-disfuncao-imunologica","tag-eixo-axl-melanoma","tag-eixo-cxcl12-cxcr4-nicho-de-lma","tag-estabilizacao-de-tipos-de-celulas-imunossupressoras-mdscs-e-macrofagos-associados-a-tumores","tag-exaustao-das-celulas-t-vias-de-sinalizacao-jak-stat","tag-expressao-de-hand1","tag-fusobacterium-nucleatum","tag-heterogeneidade-intratumoral","tag-mecanismos-de-resistencia-adaptativa","tag-mecanismos-moleculares-pt-pt","tag-melanoma-pt-pt","tag-microambiente-tumoral-tme","tag-microbioma-pt-pt","tag-mitf","tag-mutacoes-dnmt3a-e-tet2-lma","tag-oncologia-de-precisao","tag-perfis-multi-omicos","tag-plasticidade-epigenetica","tag-plasticidade-tumoral","tag-programas-dependentes-de-stat-e-mapk","tag-promocao-das-vias-de-sinalizacao-proliferativas-e-anti-apoptoticas","tag-reprogramacao-epigenetica","tag-resistencia-do-ponto-de-controlo-imunitario-melanoma","tag-subtipos-de-lma-dependentes-da-oxphos","tag-supressao-mieloide","tag-vias-de-sinalizacao-dependentes-de-smad4","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-02 14:57:09","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"pt_PT","wpml_translations":{"es_ES":{"locale":"es_ES","id":551241,"slug":"mecanismos-moleculares-de-la-plasticidad-tumoral","post_title":"Mecanismos moleculares de la plasticidad tumoral","href":"https:\/\/medizinonline.com\/es\/mecanismos-moleculares-de-la-plasticidad-tumoral\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/551246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/comments?post=551246"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/551246\/revisions"}],"predecessor-version":[{"id":551257,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/551246\/revisions\/551257"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/media\/551254"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/media?parent=551246"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/category?post=551246"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/tags?post=551246"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/powerkit_post_featured?post=551246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}