{"id":553479,"date":"2026-05-03T22:18:43","date_gmt":"2026-05-03T20:18:43","guid":{"rendered":"https:\/\/medizinonline.com\/?p=553479"},"modified":"2026-05-03T22:18:55","modified_gmt":"2026-05-03T20:18:55","slug":"semaglutide-oral-e-descompensacao-cardiaca-na-diabetes-tipo-2","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/pt-pt\/semaglutide-oral-e-descompensacao-cardiaca-na-diabetes-tipo-2\/","title":{"rendered":"Semaglutide oral e descompensa\u00e7\u00e3o card\u00edaca na diabetes tipo 2"},"content":{"rendered":"\n<p><strong>A an\u00e1lise secund\u00e1ria do ensaio SOUL do <em>JAMA Internal Medicine<\/em> 2026 comprova pela primeira vez: o semaglutide oral reduz significativamente os eventos de insufici\u00eancia card\u00edaca em doentes com insufici\u00eancia card\u00edaca pr\u00e9-existente &#8211; sem sinais de seguran\u00e7a, mesmo com terap\u00eautica concomitante com inibidores SGLT2. A insufici\u00eancia card\u00edaca \u00e9 uma das complica\u00e7\u00f5es mais comuns e de maior progn\u00f3stico da diabetes tipo 2. Os agonistas dos receptores GLP-1 em formula\u00e7\u00e3o subcut\u00e2nea j\u00e1 demonstraram ser eficazes na redu\u00e7\u00e3o dos eventos de insufici\u00eancia card\u00edaca. Com a an\u00e1lise secund\u00e1ria do ensaio SOUL, est\u00e3o agora dispon\u00edveis, pela primeira vez, dados abrangentes sobre a formula\u00e7\u00e3o oral do semaglutido &#8211; e os resultados s\u00e3o evidentes: Os resultados da insufici\u00eancia card\u00edaca s\u00e3o melhorados principalmente em pacientes com fra\u00e7\u00e3o de eje\u00e7\u00e3o preservada (HFpEF), enquanto nenhum efeito \u00e9 detet\u00e1vel em pacientes com EF reduzida (HFrEF). Uma descoberta com relev\u00e2ncia cl\u00ednica imediata.    <\/strong><\/p>\n\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/pt-pt\/a-minha-conta\/pacotes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/pt-pt\/iniciar-sessao\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fpt-pt%2Fsemaglutide-oral-e-descompensacao-cardiaca-na-diabetes-tipo-2%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>A an\u00e1lise secund\u00e1ria do ensaio SOUL do JAMA Internal Medicine 2026 comprova pela primeira vez: o semaglutide oral reduz significativamente os eventos de insufici\u00eancia card\u00edaca em doentes com insufici\u00eancia card\u00edaca&#8230;&hellip;... <\/p>\n<div class=\"pmpro\"><div class=\"pmpro_card pmpro_content_message\"><div class=\"pmpro_card_content\">Dieser Inhalt ist nur f\u00fcr Benutzer der Gruppe: Medizinische Fachperson zug\u00e4nglich <br \/><a href=\"https:\/\/medizinonline.com\/pt-pt\/a-minha-conta\/pacotes\/\">Jetzt beitreten<\/a><\/div><div class=\"pmpro_card_actions pmpro_font-medium\">Already a member? <a href=\"https:\/\/medizinonline.com\/pt-pt\/iniciar-sessao\/?redirect_to=https%3A%2F%2Fmedizinonline.com%2Fpt-pt%2Fsemaglutide-oral-e-descompensacao-cardiaca-na-diabetes-tipo-2%2F\">Log in here<\/a><\/div><\/div><\/div>","protected":false},"author":7,"featured_media":553480,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","cat_1_feature_home_top":false,"cat_2_editor_pick":false,"csco_eyebrow_text":"Insufici\u00eancia card\u00edaca e diabetes tipo 2  ","footnotes":""},"category":[11367,11397,11521,11524,11551],"tags":[18636,90984,14565,17379],"powerkit_post_featured":[],"class_list":["post-553479","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cardiologia-pt-pt","category-endocrinologia-e-diabetologia-2","category-estudos","category-formacao-continua","category-rx-pt","tag-agonista-receptor-glp-1-pt-pt","tag-alma","tag-hfpef-pt-pt","tag-semaglutidea","pmpro-level-required","pmpro-level-1","pmpro-no-access"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-11 01:00:28","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"wpml_current_locale":"pt_PT","wpml_translations":{"es_ES":{"locale":"es_ES","id":553498,"slug":"semaglutida-oral-y-descompensacion-cardiaca-en-la-diabetes-tipo-2","post_title":"Semaglutida oral y descompensaci\u00f3n cardiaca en la diabetes tipo 2","href":"https:\/\/medizinonline.com\/es\/semaglutida-oral-y-descompensacion-cardiaca-en-la-diabetes-tipo-2\/"}},"_links":{"self":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/553479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/comments?post=553479"}],"version-history":[{"count":1,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/553479\/revisions"}],"predecessor-version":[{"id":553481,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/posts\/553479\/revisions\/553481"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/media\/553480"}],"wp:attachment":[{"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/media?parent=553479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/category?post=553479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/tags?post=553479"},{"taxonomy":"powerkit_post_featured","embeddable":true,"href":"https:\/\/medizinonline.com\/pt-pt\/wp-json\/wp\/v2\/powerkit_post_featured?post=553479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}