{"id":563800,"date":"2026-09-07T00:30:00","date_gmt":"2026-09-06T22:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=563800"},"modified":"2026-09-07T07:48:15","modified_gmt":"2026-09-07T05:48:15","slug":"doenca-de-darier-tambem-conhecida-como-queratose-folicular-atualizacao-de-2026","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/pt-pt\/doenca-de-darier-tambem-conhecida-como-queratose-folicular-atualizacao-de-2026\/","title":{"rendered":"Doen\u00e7a de Darier, tamb\u00e9m conhecida como queratose folicular \u2013 Atualiza\u00e7\u00e3o de 2026"},"content":{"rendered":"\n

A doen\u00e7a de Darier \u00e9 causada por variantes patog\u00e9nicas no gene ATP2A2. Os avan\u00e7os na compreens\u00e3o da fisiopatologia abriram caminho para o desenvolvimento de abordagens terap\u00eauticas inovadoras, mas \u00e9 necess\u00e1ria mais investiga\u00e7\u00e3o para otimizar os resultados dos doentes. Isto reflete-se tamb\u00e9m na cria\u00e7\u00e3o, em 2025, da For\u00e7a-Tarefa Internacional para a Doen\u00e7a de Darier<\/em> (DD-ITF). Em doentes com doen\u00e7as graves ou refrat\u00e1rias, os retin\u00f3ides orais continuam a ser considerados a terapia sist\u00e9mica de primeira linha, mas h\u00e1 cada vez mais relatos de casos que demonstram o sucesso da utiliza\u00e7\u00e3o de terapias imunomoduladoras anti-inflamat\u00f3rias (JAK-i, biol\u00f3gicos). Isto sugere que processos inflamat\u00f3rios complexos est\u00e3o envolvidos na patog\u00e9nese.<\/strong><\/p>\n\n

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A doen\u00e7a de Darier \u00e9 causada por variantes patog\u00e9nicas no gene ATP2A2. Os avan\u00e7os na compreens\u00e3o da fisiopatologia abriram caminho para o desenvolvimento de abordagens terap\u00eauticas inovadoras, mas \u00e9 necess\u00e1ria……... <\/p>\n

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