{"id":564271,"date":"2026-09-25T12:30:00","date_gmt":"2026-09-25T10:30:00","guid":{"rendered":"https:\/\/medizinonline.com\/?p=564271"},"modified":"2026-09-21T10:57:46","modified_gmt":"2026-09-21T08:57:46","slug":"pequenas-moleculas-de-aplicacao-topica-as-janus-quinases-ou-a-pde-4-como-alvo","status":"publish","type":"post","link":"https:\/\/medizinonline.com\/pt-pt\/pequenas-moleculas-de-aplicacao-topica-as-janus-quinases-ou-a-pde-4-como-alvo\/","title":{"rendered":"\u00abPequenas mol\u00e9culas\u00bb de aplica\u00e7\u00e3o t\u00f3pica: as janus-quinases ou a PDE-4 como alvo?"},"content":{"rendered":"\n

As estruturas-alvo intracelulares, enquanto alvos terap\u00eauticos de agentes terap\u00eauticos de baixo peso molecular na dermatite at\u00f3pica (DA), t\u00eam vindo a ganhar import\u00e2ncia, e a formula\u00e7\u00e3o t\u00f3pica garante um efeito farmacol\u00f3gico local, o que contribui para um perfil de seguran\u00e7a favor\u00e1vel [1,2]. Em alguns pa\u00edses, os inibidores t\u00f3picos da Janus quinase (JAK) para a indica\u00e7\u00e3o da DA superaram os obst\u00e1culos \u00e0 autoriza\u00e7\u00e3o \u2014 assim, por exemplo, o delgocitinib foi autorizado no Jap\u00e3o e o ruxolitinib, para al\u00e9m dos EUA, foi recentemente autorizado tamb\u00e9m na UE. No que diz respeito aos inibidores t\u00f3picos da fosfodiesterase (PDE)-4, al\u00e9m do crisaborol e do roflumilast, o difamilast tamb\u00e9m obteve recentemente a autoriza\u00e7\u00e3o da FDA. <\/strong><\/p>\n\n

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As estruturas-alvo intracelulares, enquanto alvos terap\u00eauticos de agentes terap\u00eauticos de baixo peso molecular na dermatite at\u00f3pica (DA), t\u00eam vindo a ganhar import\u00e2ncia, e a formula\u00e7\u00e3o t\u00f3pica garante um efeito farmacol\u00f3gico……... <\/p>\n

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