This content is machine translated Atopic dermatitis The JAK/STAT pathway as a therapeutic target. Janus kinase (JAK) inhibitors inhibit signal transduction of numerous proinflammatory cytokines with varying selectivity. With baricitinib, upadacitinib and abrocitinib, three oral JAK inhibitors are currently approved in Switzerland for the…
View Post 6 min This content is machine translated Rosacea: drug therapy Symptom-oriented treatment strategy – patience pays off In clinical practice, it has become apparent that the previously used subtype classification inadequately reflects the collective of patients with rosacea. This is because different symptoms often overlap and the…
View Post 4 min This content is machine translated Sublingual immunotherapy (SLIT) in children Prevent asthma with targeted treatment in allergic rhinitis The use of allergen-specific immunotherapy – also known as hyposensitization – is used for the causal treatment of IgE-mediated allergies. Studies indicate that in children with allergic rhinitis, sublingual immunotherapy…
View Post 6 min This content is machine translated Inflammatory dermatoses Innovative topical therapy options for atopic dermatitis. Long-term anti-inflammatory treatment options are needed for sustainable management of chronic recurrent atopic eczema. Apart from topically applicable steroids and calcineurin inhibitors, new drug candidates for topical therapy are in…
View Post 5 min This content is machine translated Severe asthma Many antibodies lead to success If asthma patients use an inhaled corticosteroid (ICS) over a longer period of time and in high doses, even the additional combination with a long-acting β2-agonist (LABA) does not respond…
View Post 4 min This content is machine translated IgE autoreactivity in atopic dermatitis. Study shows association with type 2 comorbidities Atopic dermatitis (AD) is one of the type 2 dominant diseases, caused by complex interactions between genetics and the environment. The role of autoreactive IgE antibodies (auto-IgE) in the pathophysiology of…
View Post 4 min This content is machine translated Psoriasis Tissue-resident memory T cells as “key players”. Immunological memory plays an important role in the pathogenesis of psoriasis. Increasingly, researchers are focusing on tissue resident memory T-cells (TRM cells). This is because the persistence of TRM cells…
View Post 6 min This content is machine translated Chronic urticaria New guideline – Management of urticaria up-to-date At the beginning of 2022, the new urticaria guideline of the German Society for Allergology and Clinical Immunology and the German Dermatological Society was published. Second-generation antihistamines and omalizumab as…
View Post 3 min This content is machine translated Interdisciplinary Case Management If symptoms are nonspecific, also consider multiple chemical sensitivity Multiple Chemical Sensitivity” (MCS) is a subjectively experienced increased sensitivity to chemicals from the environment. Affected persons react with a variety of non-specific complaints. The level of suffering can be…
View Post 5 min This content is machine translated Diagnosis and therapy of chronic pruritus When itching becomes chronic, body and soul suffer – what does the new guideline say? Chronic pruritus is a multidisciplinary leading symptom associated with a high disease burden and great suffering. The updated S2k guideline provides detailed treatment recommendations for specific forms and manifestations of…
View Post 6 min This content is machine translated Atopic dermatitis How modern systems therapies relieve itching The spectrum of systemic agents approved for the treatment of moderate to severe atopic dermatitis has recently expanded, so that there is now a choice of several biologics and Janus…
