This content is machine translated Prurigo nodularis and AD Effective itch relief through inhibition of the IL-31 signaling pathway The vicious circle of itching and scratching is a central element in both prurigo nodularis (PN) and atopic dermatitis (AD). Interleukin (IL)-31, often referred to as the “itch cytokine”, has...…
View Post 8 min This content is machine translated GPP: from molecular principles to targeted therapy Therapeutic rationale for targeted IL-36 receptor inhibition The progress in the diagnosis and treatment of generalized pustular psoriasis (GPP) is remarkable. GPP has developed into a clearly defined, independent, IL-36-mediated autoinflammatory disease. Today, the high chronic disease...…
View Post 7 min This content is machine translated Pathophysiology, clinical significance and therapeutic consequences Eosinophils in asthma For a long time, eosinophils were regarded as the central effector cells of asthma and were interpreted in the classical model as a direct damaging agent of the epithelium, as...…
View Post 4 min This content is machine translated Chronic hand eczema Topical pan-JAK-i vs. systemic retinoid: head-to-head study Alitretinoin is currently the only systemic treatment approved for severe chronic hand eczema when patients do not respond adequately to topical corticosteroids. The topical pan-Janus kinase (JAK) inhibitor delgocitinib is...…
View Post 6 min This content is machine translated Actinic keratosis Field-directed therapy methods: what the European guideline recommends Topically applied medications are a cornerstone of the field-directed treatment of actinic keratoses. In photodynamic therapy, a topical agent is combined with a procedural method. In cases of insufficient response,...…
View Post 6 min This content is machine translated Itching in primary biliary cholangitis When the skin becomes agony The agonizing itching is one of the most difficult symptoms to bear in patients with primary biliary cholangitis (PBC). It can have a far greater impact on everyday life, sleep...…
View Post 2 min This content is machine translated TREATswitzerland Register Evaluation of system therapies for AD In addition to conventional immunosuppressants, several monoclonal antibodies (biologics) and Janus kinase inhibitors (JAK-i) are now approved for the systemic treatment of atopic dermatitis (AD) in Switzerland. The primary objective...…
View Post 8 min This content is machine translated Atopic dermatitis From skin barrier disorder to atopic march? An early onset and persistent course of atopic dermatitis are the strongest predictors of atopic march. New diagnostic methods such as electrical impedance spectroscopy and the analysis of biomarkers from...…
View Post 6 min This content is machine translated Galenic systems Advantages of topical pharmacotherapy – Update 2025 Topical pharmacotherapies offer the unique advantage that the products are applied directly to the diseased skin, resulting in local, distinctly direct contact between the product and the affected skin. The...… CME-Test
View Post 8 min This content is machine translated Mastocytosis Innovative pathogenesis-based therapeutic approaches in the pipeline The treatment of mastocytosis has undergone a paradigm shift in recent years. A deeper molecular understanding of the disease has paved the way from a purely symptomatic to a targeted,...…
View Post 4 min This content is machine translated Case Report Mycosis fungoides in an 11-year-old child Primary cutaneous lymphomas belong to the group of non-Hodgkin’s lymphomas. The most common form of cutaneous T-cell lymphoma is mycosis fungoides. Folliculotropic mycosis fungoides is a subtype that affects the...…
