View Post 5 minute read This content is machine translated Multiple sclerosis Unexpected side effects when switching from natalizumab to a biosimilar Education Neurology Pharmacology and toxicology RX Studies In May 2024, Imperial College Healthcare NHS Trust made extensive preparations to switch 80 patients with highly active, relapsing-remitting multiple sclerosis from an established monoclonal antibody drug to a biosimilar classified as interchangeable by the regulatory authorities. Within a few weeks, more than half of those affected reported unexpectedly severe and persistent side effects, so 42 patients were switched back to the original drug. After switching back, the symptoms improved in 90% of cases within two weeks. These observations suggest that despite formal interchangeability in clinical use, subtle differences in production, application and patient characteristics can lead to relevant variations in tolerability…. Dieser Inhalt ist nur für Benutzer der Gruppe:…
View Post 3 minute read This content is machine translated Immunotherapy Subcutaneously or intravenously? Congress Reports Oncology Pneumology RX Studies New data on the efficacy of subcutaneous immunotherapies versus intravenous therapies in NSCLC underline not only the benefits for patients but also for healthcare professionals. This is shown by analyses of a phase III study with pembrolizumab sc versus iv…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 4 minute read This content is machine translated Work-related asthma When the job leads to exacerbations Allergology and clinical immunology Education General Internal Medicine Pneumology RX Studies Asthma attacks caused by occupational exposure are very common in adults with asthma. Although previous studies have mainly focused on occupational asthma (OA), interest in work-exacerbated ast hma (WEA) has increased over the last two decades. A study from the Norwegian province of Telemark investigated the relationship between occupational risk factors and asthma exacerbations and estimated the impact on job change, sick leave and work ability…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 0 minute read This content is machine translated Inoperable NSCLC Efficacy of pembrolizumab in combination with concurrent chemoradiotherapy Congress Reports Oncology Pneumology RX Studies … Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 3 minute read This content is machine translated De-escalation strategies De-escalation strategies – less is more Congress Reports Oncology Pneumology Prevention and health care RX Drug de-escalation is primarily driven by the need to spare patients unnecessary toxicity and the associated side effects and repeated hospital visits. However, de-escalation strategies may also have the potential to reduce treatment costs…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 16 minute read This content is machine translated Pain and autism Hurdles to pain treatment for autistic patients CME continuing education Pediatrics Pharmacology and toxicology Psychiatry and psychotherapy RX Studies In contrast to neurotypical patients, the brains of neurodivergent people develop differently from the norm. Autism is defined as a form of neurodivergence. For them, deviant stimulus processing is the rule and a central but often underestimated feature of their disorder. Those affected often show an over- or under-responsiveness to sensory stimuli and an intense interest in sensory experiences. If an autism spectrum disorder is not recognized, this can lead to serious misdiagnosis, incorrect treatment and counter-indicated interventions…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here CME-Test
View Post 0 minute read This content is machine translated Advanced NSCLC MARIPOSA: Combination therapy as the new standard of care for EGFR-mutated NSCLC Congress Reports Oncology Pneumology RX Studies … Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 4 minute read This content is machine translated Pathophysiological mechanisms and therapeutic perspectives Metabolic syndrome in patients with schizophrenia Cardiology Education Psychiatry and psychotherapy RX Studies Patients with schizophrenia not only suffer from severe psychological symptoms, but also have a dramatically increased risk of cardiometabolic diseases. The interplay of disease-associated mechanisms, genetic predispositions and exogenous influences leads to the development of a metabolic syndrome in many patients, which significantly increases morbidity and mortality…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 6 minute read This content is machine translated Hand eczema: from diagnosis to treatment Implementing sustainable, stage-appropriate measures Allergology and clinical immunology Congress Reports Dermatology and venereology Pharmacology and toxicology RX Studies In everyday life, the hands are subject to high levels of stress and are therefore also exposed. Hand eczema is one of the most common clinical pictures in dermatological and occupational medicine settings. Chronic forms are common, usually due to a multifactorial etiology. While alitretinoin was the only approved systemic treatment for moderate to severe chronic hand eczema for a long time, the treatment spectrum has now been expanded with the market approval of the topical JAK inhibitor delgocitinib…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 3 minute read This content is machine translated Precision therapy Targeted MET inhibition after progression with osimertinib Congress Reports Oncology Pneumology RX Studies Despite the success of osimertinib, a third-generation EGFR-TKI, in first-line therapy, the treatment of NSCLC after progression remains a challenge. SAVANNAH and ORCHARD have investigated the targeted addition of additional agents to osimertinib after disease progression during first-line treatment with osimertinib…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
Findings from the ALS Symposium 2024 in Montreal Current and future approaches in the treatment of amyotrophic lateral sclerosis (ALS) CME continuing education Congress Reports Interviews Neurology RX Studies View Post
Findings from the ALS Symposium 2024 in Montreal Current and future approaches in the treatment of amyotrophic lateral sclerosis (ALS) Congress Reports Interviews Neurology RX Studies View Post
Artificial intelligence in medicine Opportunities and risks of AI RX CME continuing education Dermatology and venereology Education General Internal Medicine Prevention and health care View Post
Artificial intelligence in medicine Opportunities and risks of AI RX CME continuing education Dermatology and venereology Education General Internal Medicine Prevention and health care View Post
Patient-centered rounds in medicine Aligning care with the patient RX CME continuing education Education General Internal Medicine Prevention and health care Studies View Post
Thyroid Diseases Clarification of thyroid nodules RX CME continuing education Education Endocrinology and Diabetology General Internal Medicine Nuclear Medicine Oncology Radiology View Post
Patient-centered rounds in medicine Aligning care with the patient RX CME continuing education Education General Internal Medicine Prevention and health care Studies View Post
Patient-centered rounds in medicine Aligning care with the patient RX CME continuing education Education General Internal Medicine Prevention and health care Studies View Post
Advanced urothelial carcinoma of the urinary bladder Systemic therapy RX CME continuing education Education Oncology Studies Urology View Post
Palliative Care An increasing challenge for the medical profession RX Cases CME continuing education Education General Internal Medicine Prevention and health care View Post
View Post This content is machine translated Pain and autism Hurdles to pain treatment for autistic patients CME continuing education Pediatrics Pharmacology and toxicology Psychiatry and psychotherapy RX Studies In contrast to neurotypical patients, the brains of neurodivergent people develop differently from the norm. Autism is defined as a form of neurodivergence. For them, deviant stimulus processing is the rule and a central but often underestimated feature of their disorder. Those affected often show an over- or under-responsiveness to sensory stimuli and an intense interest in sensory experiences. If an autism spectrum disorder is not recognized, this can lead to serious misdiagnosis, incorrect treatment and counter-indicated interventions…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here CME-Test
View Post This content is machine translated Findings from the ALS Symposium 2024 in Montreal Current and future approaches in the treatment of amyotrophic lateral sclerosis (ALS) CME continuing education Congress Reports Interviews Neurology RX Studies Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, as yet incurable neurodegenerative disease that poses considerable medical, therapeutic and social challenges. Despite its comparatively low prevalence, ALS represents a central issue in neurological research due to its complexity and severity. New findings on molecular pathogenesis, the role of genetic factors and the development of innovative therapeutic strategies open up promising prospects for diagnosis, treatment and care. CME-Test
View Post This content is machine translated Liver steatosis with metabolic dysfunction New nomenclature for non-alcoholic fatty liver disease CME continuing education Gastroenterology and Hepatology General Internal Medicine RX Studies The term “non-alcoholic steatohepatitis” (NASH) was originally used to describe liver damage characterized by lobular inflammation, steatosis and ballooning of hepatocytes. In addition, a large proportion of patients were described as having “cryptogenic cirrhosis” at the time: The term “non-alcoholic fatty liver disease” (NAFLD) was established as the diagnosis for these patients…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here CME-Test
View Post This content is machine translated Diabetes mellitus Treatment of comorbidities in older people Cardiology CME continuing education Endocrinology and Diabetology General Internal Medicine Geriatrics RX One in five people over 65 and one in four people over 75 are affected by diabetes. Global projections predict a 2.5-fold increase in diabetes prevalence over the next 25 years. Among older people with diabetes, 30-45% are affected by frailty (Frailty) The risk of frailty increases with increasing HbA1c. The incidence of atherosclerotic cardiovascular disease (ASCVD) doubles with age, with a prevalence of 38.5% for coronary heart disease (CHD), 13% for stroke and 12% for peripheral arterial disease (PAD) in people aged ≥70 years. In addition to their glucose-controlling effect, new antidiabetic drugs have organ-protective benefits and have brought about a paradigm shift in diabetology…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt… CME-Test
