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  • 6 minute read
  • This content is machine translated COPD: Tailor therapy to individual characteristics

Risk of exacerbation correlates with the eosinophil count and other factors

The severity of COPD is determined based on lung function values, exacerbation history and symptom burden. A triple combination with inhaled steroids (ICS) is recommended for patients with a high eosinophil count and frequent exacerbations, among others. In addition, biologics have now also found their way into COPD, although only dupilumab is currently approved in Germany…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 7 minute read
  • This content is machine translated Focus on new therapeutic targets and senolytics

Cellular senescence

Cellular senescence is considered a key biological program that can exert both protective and potentially pathogenic effects in tissues across the lifespan. If senescent cells persist, they are associated with chronic inflammation, disturbed tissue homeostasis and diverse disease phenotypes. In recent years, a clinically highly relevant field of research has emerged from this: Senotherapies – in particular senolytics (selective elimination of senescent cells) and senomorphics (modulation of senescence-associated signaling and secretion patterns) – are widely studied in preclinical models, while human evidence to date comes mainly from early, small studies or from indirect clinical data sets…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson…
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  • 3 minute read
  • This content is machine translated Development of a quintuple agonist

New strategy in the fight against obesity and T2D

The treatment of obesity and type 2 diabetes is increasingly shifting to newer incretin drugs, including GLP1 receptor agonists (single agonists such as semaglutide) and GIP- and GLP1-RA (dual agonists such as tirzepatide). However, there is still a need for stronger and more selective therapies with a better effect and minimized side effect profile. In the mouse model, the quintuple agonist GLP1:GIP:PanPPAR shows promise…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 4 minute read
  • This content is machine translated From symptom to diagnosis

Oncocytoma

While renal cell carcinoma (RCC ) is the most common malignant tumor of the kidneys, accounting for around 90% of cases, oncocytoma is the rarest benign tumor of the kidneys [1]. If clinical symptoms are present, an ultrasound diagnosis is informative. Contrast-enhanced CT or MRI can be used for further imaging examinations. The latter provides diagnosis-relevant information with or without contrast medium…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 7 minute read
  • This content is machine translated Arterial elasticity, vascular ageing, endothelial function

Longevity and cardiovascular health 2025

Vascular ageing is not a purely “biological” concept, but can be measured clinically – via arterial stiffness (e.g. PWV), endothelial function (e.g. FMD) and the resulting risk profiles. In parallel to established prevention (blood pressure, lipids, smoking, exercise), two dynamic development strands are emerging: increasingly potent and longer-acting lipid-lowering drugs through to Lp(a) targeting (outcomes partly still pending), and geroprotective signaling pathway interventions (mTOR modulation), for which relevant human pilot data on endothelial function were also published in 2024/2025…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 5 minute read
  • This content is machine translated AI-supported risk stratification for chest pain in the emergency room

Performance of a fully automated ECG model

Despite guidelines, the standardized assessment of chest pain in the emergency department remains inconsistent, expensive and prone to misinterpretation. A retrospective two-center study approach published in Open Heart now presents a fully automated neural network (“Chest Pain-AI”, CP-AI) that links 12-channel ECG signals to age, gender and biomarker positivity and predicts a 7-day composite rate of severe cardiovascular diagnoses. In an external validation, CP-AI outperformed conventional models and reclassified a relevant proportion as “low risk” – with pre-fixed sensitivity of 98%…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 11 minute read
  • This content is machine translated Alternative to insulin and GLP1

From the β-cell to the center: the versatile role of amylin

Although amylin was discovered decades ago, its importance in everyday clinical practice has long been underestimated. New pharmacological developments are increasingly bringing amylin into the focus of diabetes and obesity therapy, and amylin analogs, some of which have already passed phase 3 clinical trials, are now among the most promising approaches in overweight and obesity pharmacotherapy…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 6 minute read
  • This content is machine translated Hormone balance and longevity

Ageing is not a substitution diagnosis

In the longevity debate, “hormone balance” is often used as a synonym for “biologically younger”. Clinically, the term is only meaningful if it is linked to clearly defined axial disorders, symptomatic syndromes and patient-relevant endpoints (function, fractures, events, quality of life). The hard evidence is heterogeneous: Menopausal hormone therapy is highly effective when appropriately indicated (especially vasomotor symptoms, GSM, bone), but has been characterized for decades by GHI extrapolations and warnings; in 2025, the FDA has announced the initiation of the removal of misleading boxed warnings after a comprehensive re-evaluation. Large safety data (TRAVERSE) and current FDA label changes (including blood pressure) are available for testosterone.…
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  • 6 minute read
  • This content is machine translated Cardiovascular risk

Bad news for young men with T2D

Cardiovascular disease ( CVD) remains the leading cause of death and disease worldwide, and people with type 1 or type 2 diabetes are at higher risk than the general population. Although previous studies have comprehensively analyzed the impact of diabetes on CVD, direct comparisons of CVD risk in people with T1D and T2D within each sex have been lacking. Researchers from Sweden have taken on this task…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • This content is machine translated Alternative to insulin and GLP1

From the β-cell to the center: the versatile role of amylin

Although amylin was discovered decades ago, its importance in everyday clinical practice has long been underestimated. New pharmacological developments are increasingly bringing amylin into the focus of diabetes and obesity therapy, and amylin analogs, some of which have already passed phase 3 clinical trials, are now among the most promising approaches in overweight and obesity pharmacotherapy…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • This content is machine translated Rare diseases

Yellow nail and Swyer-James syndrome

Yellow nail syndrome (YNS) is a rare disease associated with yellowing of the nails, pulmonary manifestations and lymphoedema. A clinical examination and examination of the fingernails can provide valuable information on pneumological diseases. Swyer-James syndrome (SJS) is a rare form of post-infectious bronchiolitis obliterans that usually occurs after viral respiratory infections. The typical radiological manifestation is a difference in lung translucency. The affected lung appears hypertransparent. Rare diseases such as YNS and SJS can manifest as recurrent pulmonary infections and bronchiectasis…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • This content is machine translated AI in neurology

Control instead of a flood of data: AI makes big data and wearables usable

Artificial intelligence has become a key technology in medicine, including in complex neurology. Modern methods such as machine learning and deep learning in combination with data and wearables (wearable sensor technology) enable more precise diagnostics, prognoses and treatment decisions…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • This content is machine translated Diabetic ketoacidosis

Recommendations for action in practice

Diabetic ketoacidosis (DKA) is an acutely life-threatening complication of diabetes mellitus that occurs predominantly in type 1 diabetes, but is also increasingly occurring in people with type 2 diabetes. A special form is euglycemic DKA, which mainly occurs during therapy with SGLT2 inhibitors. Even though it has become rare and the mortality rate is now only just over 1%, these deaths are usually preventable. Timely diagnosis, standardized treatment protocols and, above all, prophylaxis are crucial for the prognosis…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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