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  • 3 minute read
  • This content is machine translated "Spindle hair"

Mutations identified in another keratin gene

Monilethrix (“spindle hair”) is a dysplasia of the hair shaft with a resulting hypotrichosis. In the autosomal dominant form of this genodermatosis, causative mutations were recently identified in addition to the already known pathological gene variants in the keratin 31 gene. It is hoped that the new findings will lead to improved diagnosis of this rare disease.
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  • 4 minute read
  • This content is machine translated Case report: Cholecystocolic fistula

Gallstone ileus without symptoms

Cholecystocolic fistulas (CCF) are the second most common form of cholecystoenteric fistula (CEF). CCFs can occur atypically and result in high morbidity and mortality if not diagnosed immediately. American physicians presented a case of CCF and obstructing gallstone in an elderly man who lacked many of the expected signs, symptoms and risk factors.
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  • 6 minute read
  • This content is machine translated RSV in immunosuppression and transplantation

Risk for HSCT and SOT recipients

Although respiratory syncytial virus (RSV) is primarily known for its high burden of disease in infants and young children, it is increasingly recognized as an important cause of severe respiratory disease in adults and individuals with comorbidities. In recent years, its impact on immunocompromised patients, particularly hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients, has also been recognized.
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  • 2 minute read
  • This content is machine translated Healthcare system

Premium increase in 2025 due to continued cost growth

  • Uncategorized
The average health insurance premium will be CHF 378.70 per month in 2025, which corresponds to an increase of 6% compared to 2024. Premiums follow the costs. These will continue to grow in the future due to new therapies and medications as well as the ageing of society. Since this year, inflation has been increasingly reflected in tariffs, causing costs to rise noticeably. To ensure that the healthcare system remains financially viable, everyone is called upon to curb costs in the long term.
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  • 5 minute read
  • This content is machine translated Case report extrapulmonary tuberculosis

Watch out for signs of infection in immunocompromised patients

The majority of cases of tuberculosis (TB) affect the lungs, but around 20% of active cases are extrapulmonary tuberculosis (EPTB), which can affect any part of the human body, including bones, joints and lymph nodes. Most EPTB cases are found in HIV patients; however, the overall incidence increases with the degree of immunosuppression.
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  • 7 minute read
  • This content is machine translated Scabies

Successful anti-scabiosis treatment – current recommendations

Scabies occurs worldwide and affects people of all ages. In this country, there has recently been an increase in the number of cases. The clinical picture of scabies is varied and is largely determined by the number of mites and the age and immune status of those affected. The combination of permethrin and ivermectin is still considered the first-line treatment. There are various explanations for the recent increase in treatment failure with permethrin. Consistent implementation of the recommended measures can increase the chances of successful treatment.
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  • 5 minute read
  • This content is machine translated Sponsored Content: UEGW update: Post-hoc analyses of the SEQUENCE study

Risankizumab is convincing compared to ustekinumab [1]

The SEQUENCE comparative study recently published in the New England Journal of Medicine (NEJM) compared the two interleukin (IL)-23 and IL-12/-23 inhibitors risankizumab (SKYRIZI®) and ustekinumab in Crohn’s disease (CD) patients [1-3]. Supplementary post-hoc analyses have now been presented at this year’s United European Gastroenterology Week (UEGW) from October 12 to 15, 2024 in Vienna [4-6]. The results show, among other things, that risankizumab achieves numerically higher efficacy rates compared to ustekinumab regardless of disease duration, leads to greater normalization of biomarkers and significantly improves quality of life [4-6].
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  • 4 minute read
  • This content is machine translated Multiple sclerosis

Predicting and reducing disease activity – what is the current status?

Leading experts in the field of neurology met again this year at the world’s largest meeting for research into MS. The focus was on the clinical aspects of the disease, pathology and pathogenesis, imaging and non-imaging biomarkers as well as current and developing treatment options.
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  • 2 minute read
  • This content is machine translated Geriatric Psychiatry

Increased patient numbers, effective treatment

The results of the ANQ quality measurements in Swiss psychiatric clinics show the extent to which patients’ symptom burden decreased during inpatient treatment in 2023. The use of measures that restrict freedom was also surveyed. For the first time, the ANQ is reporting the results of geriatric psychiatry separately.
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  • This content is machine translated IBD matters – clinical studies

Differences in design and their significance for interpretation

What study phases does a new active substance go through before it reaches clinical practice? What differences are there in the designs of clinical trials?Which aspects are important for interpreting results? In this CME training article, the development of clinical trial designs in inflammatory bowel disease (IBD) will be shown and it will be explained how endpoints change from clinical measurements to patient-based data and how mixed endpoints are composed of endoscopic and patient-based assessments.
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  • This content is machine translated Alzheimer

Update on Alzheimer’s diagnosis: focus on cerebrospinal fluid and blood-based biomarkers

Despite the frequency and significance of Alzheimer’s disease, in many cases it is not diagnosed or only diagnosed at an advanced stage of the disease, which considerably limits the treatment options. Molecular CSF markers such as amyloid beta 1-42 (Aβ1-42), total tau (tau) and phosphorylated tau (pTau181) or imaging techniques such as amyloid PET are considered reliable diagnostic methods that enable early detection of Alzheimer’s core pathology. In the near future, blood-based biomarkers could become increasingly important and make diagnosis much easier, as they represent an easily accessible and more cost-effective alternative.
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  • This content is machine translated Amyotrophic lateral sclerosis

Update on diagnostics and therapy

In addition to standard care for all forms of ALS, there has been significant progress, particularly for monogenetic forms of ALS, thanks to the development of specific gene-based treatment methods, currently ASO in particular. Basic genetic diagnostics, at least of the most common genes (SOD1, C9orf72, FUS, TARDP), are therefore recommended for all ALS patients at the time of diagnosis.
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  • This content is machine translated Irritable Bowel Syndrome

Guideline-based therapy of IBS according to the biopsychosocial model

The biopsychosocial model considers various somatic and psychosocial factors within the pathophysiology of IBS and integrates their multifaceted interaction processes. In addition, therapeutic starting points can be identified and implemented on a biological, psychological and social level.
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