This content is machine translated A hub of biological aging Mitochondrial dysfunction and energy metabolism Mitochondrial dysfunction is not defined as an isolated “ATP problem” in the Hallmarks of Ageing framework, but as a systemic shift in bioenergetics, redox signaling, quality control and immune metabolism....…
View Post 8 min This content is machine translated Pharmacological therapy Anxiety symptoms in eating disorders Eating disorders are mental illnesses that are strongly influenced by biological, psychological and social stress factors. Anxiety symptoms are among the most common and most impairing accompanying symptoms. The systematic...…
View Post 4 min This content is machine translated Case study Wiedemann-Steiner syndrome in a 2-year-old girl The patient, who had a phenotype characterized by hypertelorism, thick eyebrows and other features, was found to have a c.517C>T nonsense mutation in the KMT2A gene. This rare heterozygous mutation...…
View Post 4 min This content is machine translated Psoriatic arthritis Long-term remission also possible without DMARDs Remission without disease-modifying antirheumatic drugs has become an ambitious goal in inflammatory rheumatic diseases. While it has been extensively studied in rheumatoid arthritis, its feasibility in psoriatic arthritis (PsA) has...…
View Post 5 min This content is machine translated Clinical relevance, benefits and limitations Atrial Fibrillation Screening Screening for atrial fibrillation is considered a potentially effective strategy for preventing strokes at an early stage. But how great is the actual benefit in clinical care? A recent meta-analysis...…
View Post 9 min This content is machine translated Type 2 diabetes and heart failure: a bidirectional relationship Proactive preventive measures can reduce the burden of disease Heart failure and diabetes mellitus are two of the greatest global health burdens and their prevalence is steadily increasing. At the same time, heart failure is becoming one of the...…
View Post 4 min This content is machine translated Dementia Delirium risks and treatment strategies Delirium is a common and serious neuropsychiatric disorder in elderly hospitalized patients. A large review shows: Numerous medications increase the risk of delirium, especially opioids, antipsychotics, benzodiazepines and certain antibiotics....…
View Post 9 min This content is machine translated Colorectal cancer screening Results of the population-based PREEMPT-CRC study An original investigational paper published in JAMA 2025 reports the clinical validation of an investigational, blood-based circulating tumor DNA (ctDNA) test for the early detection of colorectal cancer at average...…
View Post 5 min This content is machine translated Study report: TBS v3 and v4 in comparison Analysis of OsteoLaus study data The OsteoLaus study is part of the prospective, population-based CoLaus/PsyColaus study of postmenopausal women in Switzerland. In an analysis published in Osteoporosis International in 2025, the Trabecular Bone Score (TBS)...…
View Post 4 min This content is machine translated Study report: Nicotinamide for skin cancer prevention Cohort study analyzed data from over 30,000 patients In the US cohort study published in JAMA Dermatology 2025, the risk of non-melanocytic skin cancer (NMSC) was reduced in patients who had received nicotinamide supplementation – especially if the...…
View Post 9 min This content is machine translated Evidence, pathophysiology and management in the light of current data Heart failure with improved ejection fraction (HFimpEF) In recent years, Heart Failure with Improved Ejection Fraction (HFimpEF) has developed into a clinical entity in its own right, which is being considered in an increasingly differentiated manner. With...…
