This content is machine translated Atopic dermatitis Tralokinumab – another biologic with an excellent benefit-risk profile Since the beginning of June this year, tralokinumab – a human monoclonal IgG4 antibody that specifically binds with high affinity to the cytokine IL-13 – has been approved for adults…
View Post 4 min This content is machine translated Hidradenitis suppurativa: study report Successful treatment demonstrably improves quality of life Adalimumab (anti-TNF-α) is currently still the only approved biologic for the treatment of moderate to severe hidradenitis suppurativa (HS). In a recent “real world” 52-week study, treatment with adalimumab resulted…
View Post 5 min This content is machine translated Grass pollen allergy Preventive effects of sublingual immunotherapy greatest in children Allergen-specific immunotherapy (AIT) is a causal immunomodulatory therapy. Effective hyposensitization can reduce the risk of impending “floor change” in allergic rhinitis. Current clinical studies confirm that allergy sufferers in children…
View Post 4 min This content is machine translated Bullous pemphigoid Updated European expert guideline published The Autoimmune blistering diseases Task Force of the European Academy of Dermatology and Venereology (EADV) recently issued new recommendations for the treatment of bullous pemphigoid. The consensus expert opinion is based…
View Post 3 min This content is machine translated Atopic dermatitis The JAK/STAT pathway as a therapeutic target. Janus kinase (JAK) inhibitors inhibit signal transduction of numerous proinflammatory cytokines with varying selectivity. With baricitinib, upadacitinib and abrocitinib, three oral JAK inhibitors are currently approved in Switzerland for the…
View Post 6 min This content is machine translated Rosacea: drug therapy Symptom-oriented treatment strategy – patience pays off In clinical practice, it has become apparent that the previously used subtype classification inadequately reflects the collective of patients with rosacea. This is because different symptoms often overlap and the…
View Post 4 min This content is machine translated Sublingual immunotherapy (SLIT) in children Prevent asthma with targeted treatment in allergic rhinitis The use of allergen-specific immunotherapy – also known as hyposensitization – is used for the causal treatment of IgE-mediated allergies. Studies indicate that in children with allergic rhinitis, sublingual immunotherapy…
View Post 6 min This content is machine translated Inflammatory dermatoses Innovative topical therapy options for atopic dermatitis. Long-term anti-inflammatory treatment options are needed for sustainable management of chronic recurrent atopic eczema. Apart from topically applicable steroids and calcineurin inhibitors, new drug candidates for topical therapy are in…
View Post 5 min This content is machine translated Severe asthma Many antibodies lead to success If asthma patients use an inhaled corticosteroid (ICS) over a longer period of time and in high doses, even the additional combination with a long-acting β2-agonist (LABA) does not respond…
View Post 4 min This content is machine translated IgE autoreactivity in atopic dermatitis. Study shows association with type 2 comorbidities Atopic dermatitis (AD) is one of the type 2 dominant diseases, caused by complex interactions between genetics and the environment. The role of autoreactive IgE antibodies (auto-IgE) in the pathophysiology of…
View Post 4 min This content is machine translated Psoriasis Tissue-resident memory T cells as “key players”. Immunological memory plays an important role in the pathogenesis of psoriasis. Increasingly, researchers are focusing on tissue resident memory T-cells (TRM cells). This is because the persistence of TRM cells…
