This content is machine translated Paroxysmal Nocturnal Hemoglobinuria Relief for patients due to longer infusion intervals Chronic destruction of red blood cells is characteristic of paroxysmal nocturnal hemoglobinuria. Mutations in the PIG-A gene lead to a GPI-AP deficit that results in uncontrolled complement activation. C5 complement…
View Post 9 min This content is machine translated Reactive plasmocytoses Polyclonal plasma cell proliferation in focus. Reactive plasmocytoses are rare, but then often pronounced. They must be tested against a reactive (polyclonal) and monoclonal Plasma cell proliferation can be delineated. Accurate differential diagnosis enables effective therapy.
View Post 2 min This content is machine translated Infections in oncology A common complication brought up to date Infections are common complications of systemic therapy in hematologic and oncologic patients. However, there are few uniform definitions and little information on how to effectively treat them.
View Post 3 min This content is machine translated Deposition dermatoses Amyloidoses: early detection of cutaneous symptoms crucial Amyloidoses are a rare form of deposit dermatoses caused by defective folding of proteins. Dermatological early detection is of great importance for the further course of the disease.
View Post 2 min This content is machine translated BCL-2 Inhibition The next chapter in blood cancer therapy is opened BCL-2 inhibition represents a milestone in the history of blood cancer treatment. Approved for the treatment of relapsed or refractory chronic lymphocytic leukemia (CLL), oral small molecule is now also…
View Post 2 min This content is machine translated Immune thrombocytopenia (ITP) The patient as the focus – a change of perspective For the treatment of immune thrombocytopenia (ITP), the use of thrombopoietin receptor agonists (TPO-RA) is currently under discussion. Although steroid administration as shock therapy is still the focus of therapy.
View Post 2 min This content is machine translated CAR-T cells Focus on innovative cancer therapy CAR-T cells are currently one of the most exciting developments in immunotherapy. It combines immunotherapy, cell therapy and gene therapy and could become a routine treatment in the future.
View Post 5 min This content is machine translated Eosinophils Severe asthmatics are more likely to suffer from systemic steroids If a diagnosis of severe asthma is confirmed, adjunctive therapy with monoclonal antibodies may be considered. Currently, anti-IgE or anti-IL5 antibodies are available for this purpose, depending on the phenotype.…
View Post 2 min This content is machine translated Iron deficiency Effective management of a cardio-renal patient. Heart failure often does not come alone. One third of the patients also suffer from renal insufficiency. A major challenge here is the iron deficiency that often occurs. Interdisciplinary management…
View Post 1 min This content is machine translated Hematologic neoplasms Differentiated diagnostics for effective results Differentiated diagnostic options are designed to enable therapy that is tailored to individual needs. However, in hematologic neoplasms, established treatment options are also effective.
View Post 10 min This content is machine translated Myeloproliferative neoplasms Polycythemia vera: pathogenesis, clinical, diagnostic and therapeutic implications. Hematopoietic stem cell myeloproliferative neoplasia is predominantly caused by somatic mutations of the JAK2 gene and resulting clonal autonomous hematopoiesis. The risk of myelofibrosis or leukemic transformation are prognostic.
