This content is machine translated Case Report 76-year-old patient with pustular skin rash The efficacy of spesolimab in the treatment of generalized pustular psoriasis (GPP) is well documented in the literature. In the present case study, spesolimab therapy was administered in parallel with...…
View Post 8 min This content is machine translated GPP: from molecular principles to targeted therapy Therapeutic rationale for targeted IL-36 receptor inhibition The progress in the diagnosis and treatment of generalized pustular psoriasis (GPP) is remarkable. GPP has developed into a clearly defined, independent, IL-36-mediated autoinflammatory disease. Today, the high chronic disease...…
View Post 4 min This content is machine translated Pustular psoriasis What is known about inflammatory mechanisms in PPP and GPP? Pustular psoriasis is characterized by the sudden appearance of small, pus-filled blisters (“pustules”). The clinical, pathological and genetic features of GPP and PPP differ from plaque psoriasis. While in GPP...…
View Post 4 min This content is machine translated Case Report Successful treatment of an acute GPP flare-up Generalized pustular psoriasis (GPP) is a neutrophilic, inflammatory skin disease with a potentially life-threatening course. Recent findings on immunopathogenesis indicate that the group of interleukin (IL)-36 cytokines are central drivers…
View Post 5 min This content is machine translated Pustular psoriasis Current overview of PPP and GPP Pustular forms of psoriasis are relatively rare. An IL-36RN mutation is more common in the generalized subtype (GPP) than in the palmoplantar-restricted subtype (PPP). Both disease entities can occur independently…
View Post 6 min This content is machine translated Generalized Pustular Psoriasis (GPP) What is currently known about this rare systemic disease? Macroscopically visible sterile, confluent pustules on non-acral skin and extensive erythema and edema are among the characteristic manifestations of generalized pustular psoriasis – a severe inflammatory, potentially life-threatening skin disease.…
