This content is machine translated GPP: from molecular principles to targeted therapy Therapeutic rationale for targeted IL-36 receptor inhibition The progress in the diagnosis and treatment of generalized pustular psoriasis (GPP) is remarkable. GPP has developed into a clearly defined, independent, IL-36-mediated autoinflammatory disease. Today, the high chronic disease...…
View Post 4 min This content is machine translated Case Report Successful treatment of an acute GPP flare-up Generalized pustular psoriasis (GPP) is a neutrophilic, inflammatory skin disease with a potentially life-threatening course. Recent findings on immunopathogenesis indicate that the group of interleukin (IL)-36 cytokines are central drivers…
View Post 5 min This content is machine translated Pustular psoriasis Current overview of PPP and GPP Pustular forms of psoriasis are relatively rare. An IL-36RN mutation is more common in the generalized subtype (GPP) than in the palmoplantar-restricted subtype (PPP). Both disease entities can occur independently…
