This content is machine translated Acute myeloid leukemia (AML) “A new standard of care for elderly and fragile patients” A BCL-2 inhibitor is convincing in new studies in the first-line treatment of AML patients who are not suitable for intensive chemotherapy [1]. Hematologists Dr. Georgios Georgiou and Prof. Photis…
View Post 5 min This content is machine translated Paroxysmal nocturnal hemoglobinuria (PNH) From iron deficiency to diagnosis Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disease characterized by intravascular hemolysis and hemoglobinuria. Due to a prolonged loss of hemoglobin through the urine, PNH can lead to iron…
View Post 5 min This content is machine translated Multiple Myeloma Focus on first-line therapy The innovation of recent years has long since found its way into first-line therapy in multiple myeloma. Thus, the EHA-ESMO Guidelines were amended accordingly in January. Daratumumab, a monoclonal antibody…
View Post 6 min This content is machine translated CAR-T cell therapy Paving the way to success With the increasing clinical application of CAR-T cells, the practical aspects of therapy are a growing concern. Which patients should receive treatment using CAR-T cells outside of clinical trials? What…
View Post 4 min This content is machine translated Hodgkin's disease Excess mortality after surviving disease: a search for causes Today, more than 80% of all patients with Hodgkin lymphoma can be cured, and in early stages even more than 90%. Nevertheless, the disease and its therapy have a significant…
View Post 3 min This content is machine translated Monoclonal Gammopathy of Unclear Significance (MGUS) Identification of patients at risk Patients with monoclonal gammopathy of uncertain significance (MGUS) are at increased risk of developing certain forms of cancer. Regular checks allow changes to be detected at an early stage and…
View Post 2 min This content is machine translated Leukemic cutaneous T-cell lymphoma (L-CTCL) Sézary syndrome and mycosis fungoides: STAT5 as a therapeutic target? As the disease progresses, the tumor cells in leukemic variants of cutaneous T-cell lymphomas spread not only in the skin but also in the blood and lymph nodes. Although an…
View Post 6 min This content is machine translated Liquid Biopsy The future of oncological diagnostics With the increasing variety of personalized and immuno-oncological therapeutic options, the importance of predictive markers is also increasing. To date, tissue diagnostics, including invasive biopsy, are necessary to determine this.…
View Post 10 min This content is machine translated Multiple Myeloma A portrait of a multifaceted disease The introduction of new drugs has steadily improved the prognosis of patients with multiple myeloma over the past years. Diagnostics have also been expanded, in particular by cytogenetic analyses, which…
View Post 11 min This content is machine translated Aggressive lymphomas Therapy in everyday clinical practice based on current developments Lymphoma accounts for 3.8% of all new cancer diagnoses. According to the current WHO classification, there are over 75 different lymphomentities, which are treated differently. In the treatment of diffuse… CME-Test
View Post 5 min This content is machine translated Chronic lymphocytic leukemia BTK inhibitors and other hopefuls The therapy of chronic lymphocytic leukemia (CLL) is currently undergoing rapid change. Increasingly, chemoimmunotherapy, which has been commonly used in the past, is being replaced by more targeted treatments. In…
