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Pharmacology and toxicology

315 posts
  • This content is machine translated Schizophrenia

Partial D2 dopamine agonists: pharmacology and clinical significance.

Schizophrenia is characterized, among other things, by dopaminergic dysregulation. All antipsychotics approved for their treatment are antagonists of dopamine receptors, particularly D2 and D3 receptors. The three partial D2 dopamine…
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  • 4 min
  • This content is machine translated SARS-CoV-2

Pelargonium sidoides shows antiviral and immunomodulatory effects in vitro.

Currently available treatment options against Covid-19 are very limited and research for effective drugs is feverish. An international team of scientists recently published results of a preclinical in vitro study indicating…
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  • 3 min
  • This content is machine translated ART: "single tablet" regimen with triple combination.

Compelling “real world” data in HIV patients over 65 years of age.

There are increasing numbers of older people living with HIV, but the 65+ age group is generally underrepresented in clinical trials. An ongoing study in a “real world” setting is…
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  • 3 min
  • This content is machine translated Heart failure

HFrEF – the four pillars of modern pharmacotherapy

Chronic heart failure is one of the leading causes of death and reasons for hospitalization in developed countries. The prognosis is often poor – within five years, about half of…
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  • 3 min
  • This content is machine translated Multiple sclerosis

Personalized medicine at the cutting edge

Intensive research in the field of multiple sclerosis (MS) has led to the availability of different treatment options – depending on the form of the disease and its severity. This…
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  • 3 min
  • This content is machine translated Sleep disorders

Effective therapy management for restful sleep

Humans sleep through one third of their lives. The body needs sleep to regenerate, form new cells, and strengthen memory and the immune system. Accordingly, sleep disorders have a high…
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  • 14 min
  • This content is machine translated Epilepsy

Patient-centered pharmacotherapy of epilepsy.

The arsenal of available pharmacotherapies for the treatment of epilepsy has expanded dramatically in recent years. More targeted selection and prioritization based on the form of epilepsy, consideration of comorbidities,…
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  • 5 min
  • This content is machine translated Depression in old age

Pharmacotherapy as an important pillar of treatment

Depressive disorders are among the most common mental illnesses, and many older people also suffer from them. Nowadays, a biopsychosocial explanatory model is assumed. In addition to psychotherapy and general…
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  • 13 min
  • This content is machine translated Drug effects in the gastrointestinal tract.

Side effects on small and large intestine

A variety of medications can cause drug side effects on the small and large intestines. The focus will be on the major gastrointestinal drug side effects and their main triggers.…
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  • 3 min
  • This content is machine translated Oral anticoagulation

Practice guideline supports DOAK administration in special situations

Experience with the use of direct oral anticoagulants is growing steadily. Many studies show clear superiority over vitamin K antagonists. However, it has not yet been possible to create a…
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  • 6 min
  • This content is machine translated The Parkinson therapy in the very old

Age does not make it better

Although old age is not typical for PD and there are also young patients, the disease has always been associated with elderly people. Sufferers also often have to contend with…

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