Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patients
    • Disease patterns
    • Diagnostics
    • Therapy
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Forum Gastroenterology
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Allergology and clinical immunology
    • General Internal Medicine
    • Anesthesiology
    • Angiology
    • Surgery
    • Dermatology and venereology
    • Endocrinology and Diabetology
    • Nutrition
    • Gastroenterology and Hepatology
    • Genetics
    • Geriatrics
    • Gynecology
    • Hematology
    • Infectiology
    • Cardiology
    • Nephrology
    • Neurology
    • Emergency and intensive care medicine
    • Nuclear Medicine
    • Oncology
    • Ophthalmology
    • ORL
    • Orthopedics
    • Pediatrics
    • Pharmacology and toxicology
    • Pharmaceutical medicine
    • Phlebology
    • Physical medicine and rehabilitation
    • Pneumology
    • Prevention and health care
    • Psychiatry and psychotherapy
    • Radiology
    • Forensic Medicine
    • Rheumatology
    • Sports Medicine
    • Traumatology and trauma surgery
    • Tropical and travel medicine
    • Urology
    • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
  • Log In
  • Register
  • My account
  • Contact
  • English
    • Deutsch
    • Français
    • Italiano
    • Português
    • Español
  • Publications
  • Contact
  • Deutsch
  • English
  • Français
  • Italiano
  • Português
  • Español
Subscribe
Medizinonline Medizinonline
Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patienten
    • Krankheitsbilder
    • Diagnostik
    • Therapie
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Forum Gastroenterology
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Fachbereiche 1-13
      • Allergology and clinical immunology
      • General Internal Medicine
      • Anesthesiology
      • Angiology
      • Surgery
      • Dermatology and venereology
      • Endocrinology and Diabetology
      • Nutrition
      • Gastroenterology and Hepatology
      • Genetics
      • Geriatrics
      • Gynecology
      • Hematology
    • Fachbereiche 14-26
      • Infectiology
      • Cardiology
      • Nephrology
      • Neurology
      • Emergency and intensive care medicine
      • Nuclear Medicine
      • Oncology
      • Ophthalmology
      • ORL
      • Orthopedics
      • Pediatrics
      • Pharmacology and toxicology
      • Pharmaceutical medicine
    • Fachbereiche 26-38
      • Phlebology
      • Physical medicine and rehabilitation
      • Phytotherapy
      • Pneumology
      • Prevention and health care
      • Psychiatry and psychotherapy
      • Radiology
      • Forensic Medicine
      • Rheumatology
      • Sports Medicine
      • Traumatology and trauma surgery
      • Tropical and travel medicine
      • Urology
      • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
Login

Sie haben noch keinen Account? Registrieren

  • EADV Congress

A tattoo leaves not only beautiful traces

    • Congress Reports
    • Dermatology and venereology
    • RX
  • 4 minute read

The EADV Congress is the largest dermatological and venereological educational event in Europe. In 2014, the numerous international clinical and research experts met in Amsterdam. The official press conference on this was held on October 10. It provided an initial overview of the wide variety of topics in this field. Sometimes it was about tattoos, anti-aging cosmetics, hair transplants and melanoma therapy.

Tattoos are booming, according to Prof. Jørgen Serup, MD, Copenhagen. This fashion trend – currently an estimated 100 million Europeans are tattooed – certainly brings risks with it. Not least because the dyes used are little standardized and regulated, they are products that are sometimes hardly subject to quality control, are poorly labeled and sometimes even contain unknown ingredients.

A Danish study showed a full 10% of the 58 new inks tested were contaminated with bacteria that can lead to infections, including staphylococci, streptococci, pseudomonas, enterococci and E.coli. Bacterial infections potentially spread to the surrounding skin or even affect deeper tissue. Depending on the resistance of the bacteria, antibiotic therapy is more or less successful – MRSA (penicillin-resistant staphylococci) are also found in tattoos and are increasingly spreading throughout Europe.

A wide range of consequential problems

Mild but also relatively common complications after tattooing include specific skin reactions to sunlight, swelling and pruritus. “The problem is that many people who notice any symptoms after such a procedure do not go to the doctor – after all, from their own perspective, they are not sick, but have merely had themselves beautified,” he said. Only when the swelling or pruritus becomes chronic, the doctor is consulted.

However, among the most dangerous situations are allergic reactions: The spectrum ranges from rather superficial, slightly elevated, flat or scaly lesions to ulcers affecting deeper skin layers and leading to a chronic wound. Potentially life-threatening consequences of tattooing are summarized in Table 1. “Stronger regulation and control of this growing business sector (especially the use and manufacture of inks) is needed in any case,” Prof. Serup cautioned.
 

Are there evidence-based anti-aging products?

The question of whether signs of skin aging can really be reduced by means of certain cosmetics was discussed by Tatjana Pavicic, MD, Munich. “As people are getting older and want to remain active and attractive into old age, there is a great demand for anti-aging products. In the course of this development, which also promises productive sales in the future, various manufacturers brought active ingredients onto the market, which now have to be tested very precisely and scientifically adequately for their desirable and negative effects. Advertising rarely delivers what it promises.” In the final analysis, this means clinically controlled double-blind in vivo studies. Two categories of effect can be distinguished on the basis of the active ingredients in these products:

  1. Antioxidants such as vitamins, co-enzymes and phytochemicals.
  2. Cell regulators such as retinol, peptides and growth factors.

The current scientific evidence status of various ingredients is shown in Table 2 . The gold standard includes retinol, which has been shown to stimulate epidermal proliferation and the synthesis of collagen, elastic fibers, and glycosaminoglycans, and to act on skin-damaging matrix metalloproteinases (MMPs). Vitamin C and polypeptides also sometimes increase collagen synthesis.
 

However, recommendations must not only be based on scientific evidence and tolerability data, but must also take into account the individually defined skin aging status. Is something to be prevented or “fixed”? In general, the current condition of the skin is decisive for the choice of therapy (dryness, inflammation, etc.). “I would start with antioxidants in early stages of aging and add cell regulators later, after the age of 40. One should use the synergistic effects of different active ingredients and apply combination regimens,” Dr. Pavicic summarized. In addition, UV-A and -B protection as well as exercise, a healthy diet, stress reduction and an ample intake of water are essential.

Stem cell transplantation for hair loss

The stem cell method differs from other techniques in that only a small piece of the hair follicle is taken. “Although we co-transplant parts of the hair root, the main goal of this technique is to transplant enough hair stem cells because they can effectively regenerate hair growth. Recently, it has been shown that the stem cells are located at the side and not at the base of the hair root. Therefore, it is necessary to transplant only a tiny section and not the whole follicular unit. Not all stem cells are necessary for regeneration. The principle is based on multiplication: from one hair you can generate two,” explained Coen Gho, MD, Amsterdam. “The donor follicles are preserved through the minimally invasive procedure.”

According to the speaker, neither loss of density nor scarring of the donor region results from such a transplantation (the microscopic wounds heal completely after two days). The same site will be considered for transplantation again (if needed) a few months later. However, the removal is very labor intensive and costly.

Melanoma therapy – Are the new agents too expensive?

Finally, Prof. Dr. med. Claus Garbe, Tübingen, raised the question whether the new therapies in the field of melanoma are cost-effective. “There is a lot to suggest that they are not. The manufacturer sets the price itself, which is usually very high and not based on real production costs or entirely on development costs.” It is also clear that this price far exceeds the benefit in QALYs (health economic metric consisting of lifetime and quality of life), so the cost-benefit ratio is not right. Rather, pharmaceutical manufacturers would set the price based on market research: opinion leaders would be interviewed and asked about the pain threshold or possible upper limit in the market. However, this significantly exceeds certain thresholds – which will make it impossible for healthcare systems to implement these drugs on a broad scale. “Thus, while we have promising new drugs, not every patient will be able to benefit,” Prof. Garbe explained.

According to the speaker, the solution lies in stricter price regulation (e.g., by the National Institute for Health and Clinical Excellence or the Federal Joint Committee [G-BA] in Germany).

Source: Press conference EADV Congress, October 8-12, 2014, Amsterdam

DERMATOLOGY PRACTICE 2015; 25(1): 37-39

Autoren
  • Andreas Grossmann
Publikation
  • DERMATOLOGIE PRAXIS
Previous Article
  • Mantle cell lymphoma

First- and second-line lenalidomide

  • Congress Reports
  • Oncology
  • RX
  • Studies
View Post
Next Article
  • Pulmonary emphysema

When is interventional therapy indicated?

  • Education
  • General Internal Medicine
  • Pneumology
  • RX
View Post
You May Also Like
View Post
  • 10 min
  • Cutaneous lupus erythematosus

From diagnostic workup to successful treatment

    • Congress Reports
    • Dermatology and venereology
    • RX
    • Studies
View Post
  • 4 min
  • Guideline update

Dietary recommendations for Crohn’s disease and colitis

    • Education
    • Gastroenterology and Hepatology
    • General Internal Medicine
    • Nutrition
    • RX
    • Studies
View Post
  • 4 min
  • Circadian rhythm during Ramadan

Disturbed sleep patterns lead to metabolic stress

    • Education
    • Endocrinology and Diabetology
    • General Internal Medicine
    • Nutrition
    • RX
    • Studies
View Post
  • 6 min
  • Case Report

Breast cancer metastases in the bladder

    • Cases
    • Education
    • Gynecology
    • Oncology
    • RX
    • Urology
View Post
  • 11 min
  • Findings from the ALS Symposium 2024 in Montreal

Current and future approaches in the treatment of amyotrophic lateral sclerosis (ALS)

    • Congress Reports
    • Interviews
    • Neurology
    • RX
    • Studies
View Post
  • 8 min
  • Efficacy, mechanism of action and clinical effects

Garlic and high blood pressure

    • Cardiology
    • Education
    • General Internal Medicine
    • Pharmaceutical medicine
    • Phytotherapy
    • RX
    • Studies
View Post
  • 7 min
  • Moderate to severe chronic hand eczema

Delgocitinib cream – first topical pan-JAK inhibitor approved in Switzerland

    • Allergology and clinical immunology
    • Dermatology and venereology
    • Education
    • Infectiology
    • Market & Medicine
    • Pharmacology and toxicology
    • RX
View Post
  • 9 min
  • Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CA)

Diagnosis at an early stage, prognostic classifications and outlook

    • Cardiology
    • Education
    • RX
    • Studies
Top Partner Content
  • Forum Gastroenterology

    Zum Thema
  • Herpes zoster

    Zum Thema
  • Dermatology News

    Zum Thema
Top CME content
  • 1
    Patience, knowledge and persistence in therapy
  • 2
    Sarcopenia and malnutrition in the context of pneumological rehabilitation
  • 3
    Medical and psychosocial perspectives
  • 4
    New nomenclature for non-alcoholic fatty liver disease
  • 5
    Examinations and considerations before therapy

Newsletter

Sign up and stay up to date

Subscribe
Medizinonline
  • Contact
  • General terms and conditions
  • Imprint

Input your search keywords and press Enter.