Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patients
    • Disease patterns
    • Diagnostics
    • Therapy
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Forum Gastroenterology
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Allergology and clinical immunology
    • General Internal Medicine
    • Anesthesiology
    • Angiology
    • Surgery
    • Dermatology and venereology
    • Endocrinology and Diabetology
    • Nutrition
    • Gastroenterology and Hepatology
    • Genetics
    • Geriatrics
    • Gynecology
    • Hematology
    • Infectiology
    • Cardiology
    • Nephrology
    • Neurology
    • Emergency and intensive care medicine
    • Nuclear Medicine
    • Oncology
    • Ophthalmology
    • ORL
    • Orthopedics
    • Pediatrics
    • Pharmacology and toxicology
    • Pharmaceutical medicine
    • Phlebology
    • Physical medicine and rehabilitation
    • Pneumology
    • Prevention and health care
    • Psychiatry and psychotherapy
    • Radiology
    • Forensic Medicine
    • Rheumatology
    • Sports Medicine
    • Traumatology and trauma surgery
    • Tropical and travel medicine
    • Urology
    • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
  • Log In
  • Register
  • My account
  • Contact
  • English
    • Deutsch
    • Français
    • Italiano
    • Português
    • Español
  • Publications
  • Contact
  • Deutsch
  • English
  • Français
  • Italiano
  • Português
  • Español
Subscribe
Medizinonline Medizinonline
Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patienten
    • Krankheitsbilder
    • Diagnostik
    • Therapie
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Forum Gastroenterology
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Fachbereiche 1-13
      • Allergology and clinical immunology
      • General Internal Medicine
      • Anesthesiology
      • Angiology
      • Surgery
      • Dermatology and venereology
      • Endocrinology and Diabetology
      • Nutrition
      • Gastroenterology and Hepatology
      • Genetics
      • Geriatrics
      • Gynecology
      • Hematology
    • Fachbereiche 14-26
      • Infectiology
      • Cardiology
      • Nephrology
      • Neurology
      • Emergency and intensive care medicine
      • Nuclear Medicine
      • Oncology
      • Ophthalmology
      • ORL
      • Orthopedics
      • Pediatrics
      • Pharmacology and toxicology
      • Pharmaceutical medicine
    • Fachbereiche 26-38
      • Phlebology
      • Physical medicine and rehabilitation
      • Phytotherapy
      • Pneumology
      • Prevention and health care
      • Psychiatry and psychotherapy
      • Radiology
      • Forensic Medicine
      • Rheumatology
      • Sports Medicine
      • Traumatology and trauma surgery
      • Tropical and travel medicine
      • Urology
      • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
Login

Sie haben noch keinen Account? Registrieren

  • α-Synuclein immunoreactivity at the enteric nervous system.

Biomarkers for prodromal parkinsonism syndrome?

    • Neurology
    • RX
    • Studies
  • 2 minute read

Purpose: This multicenter controlled observational study investigates α-synuclein immunoreactivity at the enteric nervous system in patients with idiopathic REM sleep behavior disorder (iRBD) and controls as a possible biomarker for prodromal parkinsonian syndrome.

Background

Longitudinal studies suggest that REM sleep behavior disorders are a prodromal stage for subsequent Parkinson’s disease in up to 80% of cases. Other biomarkers for prodromal parkinsonian syndromes include hyposmia, impaired color vision, presynaptic dopamine transporter deficit in the putamen, and hyperechogenicity of the substantia nigra on transcranial ultrasound. The aim is to detect prodromal Parkinson’s syndromes as early as possible in order to be able to conduct studies on disease prevention in the future.

Patients and methodology

The multicenter controlled observational study included 20 patients with polysomnographically confirmed iRBD, 24 patients with Parkinson’s disease according to the UK Parkinson’s Disease Society Brain Bank diagnostic criteria, and 22 healthy controls. Colon biopsies were taken from all of them. In addition to olfaction (UPSIT and Sniffin’ Sticks) and possible parkinsonian symptoms (MDS-UPDRS parts I-III), biopsies were examined immunohistochemically for phosphorylated and nonphosphorylated α-synuclein.

Results

Compared with the control group and iRBD patients, PD patients had significantly higher scores in MDS-UPDRS, as expected. The sense of smell was significantly reduced in both Parkinson’s and iRBD patients. While all biopsies contained sufficient amounts of mucosa for further analysis, with regard to submucosa, this was the case only in 16 controls, 21 PD and 17 iRBD patients. Non-phosphorylated α-synuclein was detected in the submucosa of all patients and controls. In the mucosa, phosphorylated α-synuclein could not be detected in any group. In the submucosa, phosphorylated α-synuclein was found in four of 17 iRBD patients, but in one of 19 PD patients, but in none of the control group, but without reaching the significance level.

Conclusions of the authors

Considering further work, it is concluded that antibodies directed against non-phosphorylated (native) α-synuclein have no value as biomarkers for prodromal parkinsonian syndromes. Although no significant difference was found, the detection of phosphorylated α-synuclein in four of 17 iRBD patients and none of the controls is interpreted by the authors as possible evidence for a relevant difference. However, it remains unclear why this can no longer be detected in Parkinson’s patients. A connection with a possible nerve cell loss in the course of the disease is discussed. Other complicating factors in performing these and similar studies include different techniques and targets of the antibodies used.

Comment

The early correct diagnosis of Parkinson’s disease is not only important in clinical routine (here it is particularly important to distinguish it from other atypical forms), but is also particularly important in current scientific questions of disease prevention and causal influence on the course of the disease. Thus, the search for suitable biomarkers is directly related to the search for causal therapeutic options. The early manifestation of α-synucleinopathy in the gastrointestinal system would also be consistent with the hypothesis that the disease originates there and spreads via the vagus nerve to the brainstem and then to the other brain regions.

 

InFo NEUROLOGY & PSYCHIATRY 2016; 14(2): 33.

Autoren
  • Dr. med. Robert Stark
Publikation
  • InFo NEUROLOGIE & PSYCHIATRIE
Previous Article
  • Parkinson's

Coffee consumption and risk of levodopa-induced dyskinesias.

  • Neurology
  • Nutrition
  • RX
  • Studies
View Post
Next Article
  • Allergo update 2016

Current developments in allergology

  • Allergology and clinical immunology
  • Congress Reports
  • Dermatology and venereology
  • Pediatrics
  • RX
View Post
You May Also Like
View Post
  • 3 min
  • Therapy adherence and patient selection

Injection fatigue in relapsing-remitting multiple sclerosis

    • Education
    • Neurology
    • RX
    • Studies
View Post
  • 5 min
  • Deep vein thrombosis

Outpatient or inpatient treatment?

    • Angiology
    • Cardiology
    • Congress Reports
    • General Internal Medicine
    • Phlebology
    • RX
    • Studies
View Post
  • 5 min
  • Sarcoidosis, echinococcosis & Co.

Suspected symptoms and differential diagnoses

    • Cardiology
    • Cases
    • Congress Reports
    • Pneumology
    • RX
View Post
  • 12 min
  • Cancer prevention

Constant dripping – alcohol and cancer

    • CME continuing education
    • General Internal Medicine
    • Oncology
    • Pharmacology and toxicology
    • Prevention and health care
    • Psychiatry and psychotherapy
    • RX
    • Studies
View Post
  • 7 min
  • Steatotic liver disease

GLP-1RA in MASH – what’s new?

    • Congress Reports
    • Endocrinology and Diabetology
    • Gastroenterology and Hepatology
    • General Internal Medicine
    • Pharmacology and toxicology
    • RX
    • Studies
View Post
  • 6 min
  • Chronic pruritus: “Tour d'horizon”

Focus on new anti-inflammatory therapeutic approaches

    • Allergology and clinical immunology
    • Congress Reports
    • Dermatology and venereology
    • Pharmacology and toxicology
    • RX
    • Studies
View Post
  • 5 min
  • Multiple sclerosis

Unexpected side effects when switching from natalizumab to a biosimilar

    • Education
    • Neurology
    • Pharmacology and toxicology
    • RX
    • Studies
View Post
  • 3 min
  • "Patients W.A.I.T. Indicator"

Access to new drugs is becoming increasingly difficult

    • Oncology
    • Pharmacology and toxicology
    • Practice Management
    • RX
    • Studies
Top Partner Content
  • Forum Gastroenterology

    Zum Thema
  • Herpes zoster

    Zum Thema
  • Dermatology News

    Zum Thema
Top CME content
  • 1
    Constant dripping – alcohol and cancer
  • 2
    Hurdles to pain treatment for autistic patients
  • 3
    Current and future approaches in the treatment of amyotrophic lateral sclerosis (ALS)
  • 4
    Treatment of comorbidities in older people
  • 5
    New nomenclature for non-alcoholic fatty liver disease

Newsletter

Sign up and stay up to date

Subscribe
Medizinonline
  • Contact
  • General terms and conditions
  • Imprint

Input your search keywords and press Enter.