This content is machine translated Atopic dermatitis in the era of precision medicine Research into molecular biomarkers opens up new horizons The identification and study of molecular biomarkers may help to dissect the complex phenotype of atopic dermatitis into subphenotypes. A long-term goal of this translational research is the stratification and…
View Post 6 min This content is machine translated Study Report Palmoplantar psoriasis – a diagnostic challenge Because many clinical and histopathologic features of palmoplantar psoriasis (PP) overlap with those of other dermatoses, differential diagnosis is far from trivial. With this in mind, a research team analyzed…
View Post 3 min This content is machine translated Plaque psoriasis Current 5-year data on secukinumab A long-term extension analysis of the ERASURE and FIXTURE studies recently published in the British Journal of Dermatology demonstrates the long-lasting efficacy and safety of secukinumab in patients with moderate-to-severe…
View Post 8 min This content is machine translated Translational medicine Psoriasis – from immunopathogenesis to successful therapy The innovative systemic treatments for psoriasis are a prime example of translational medicine. In a review published last year in the Journal of Investigative Dermatology, Prof. Peter van de Kerkhof,…
View Post 5 min This content is machine translated Systemic mastocytosis Pathological mast cell infiltration – a clinical challenge In patients with highly elevated tryptase levels, KIT mutation analysis from bone marrow is recommended. Especially in adults, a point mutation in codon 816 of the KIT gene can often…
View Post 7 min This content is machine translated Dermatomyositis Diagnostics and treatment – a current overview Pathognomonic skin signs of dermatomyositis include heliotrope erythema, Gottron papules, and Gottron signs. The determination of myositis-specific autoantibodies has an increasingly important role in the diagnosis. Regarding treatment options, intravenous…
View Post 3 min This content is machine translated Plaque psoriasis TYK2 inhibition shows great therapeutic potential Psoriasis is nowadays understood as a systemic disease, which is based on chronic inflammation. Research into the etiopathogenesis, as well as the establishment of new active substances, is progressing rapidly.…
View Post 4 min This content is machine translated Severe asthma No musclemen in the waiting room Many asthmatics, especially those with severe disease, report mobility problems and limitations in daily activities that severely affect their quality of life. Among the contributing factors, low muscle mass and…
View Post 4 min This content is machine translated Biologics for atopic dermatitis Symptom relief through targeted inhibition of inflammatory signaling pathways Monoclonal antibodies are systems therapeutics that block specific cytokines or receptors and can thus selectively influence individual activation cascades of the immune system. Both dupilumab and tralokinmab – the two…
View Post 3 min This content is machine translated Atopic dermatitis Multifactorial etiology with dysregulation of type 2 cytokines. Genetic predisposition, an impaired epidermal barrier with altered microbiome, and aberrant immune responses with type 2 inflammation are associated with the occurrence and activity of atopic dermatitis. Various provoking factors…
View Post 3 min This content is machine translated Chronic cough Asthma, COPD, or postinfectious? Anyone who struggles with a respiratory tract infection during the cold season almost always suffers from an unpleasant cough associated with it. This can be quite persistent, but usually disappears…
