This content is machine translated Atrial fibrillation: interdisciplinary effort is crucial Managing risk factors and comorbidities in addition to rhythm control The previously used “ABC” scheme was replaced by the more comprehensive “CARE” approach in the ESC guideline published in 2024. Drug therapy for atrial fibrillation is primarily aimed at preventing...…
View Post 2 min This content is machine translated Ulcerative colitis Rgs14 protein can worsen the severity Rgs14 is a protein that acts as a regulator of G-protein signaling pathways by accelerating the GTPase activity of G-protein alpha subunits and thereby converting them to their inactive GDP-bound...…
View Post 8 min This content is machine translated Mastocytosis Innovative pathogenesis-based therapeutic approaches in the pipeline The treatment of mastocytosis has undergone a paradigm shift in recent years. A deeper molecular understanding of the disease has paved the way from a purely symptomatic to a targeted,...…
View Post 6 min This content is machine translated Lipid management: ESC/EAS guideline update 2025 New recommendations on CVD risk classification, lipid lowering in statin intolerance and hoFH The European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) guideline update on the management of dyslipidemia continues to focus largely on how best to manage lipid levels to...…
View Post 8 min This content is machine translated Lung cancer with EGFR mutation New perspectives in first-line therapy At this year’s IASLC World Conference on Lung Cancer (WCLC 2025) in Barcelona, a poster on the FLAURA2 study was presented, which presented new data on combination therapy with osimertinib...…
View Post 7 min This content is machine translated Prurigo nodularis and AD Effective itch relief through inhibition of the IL-31 signaling pathway The vicious circle of itching and scratching is a central element in both prurigo nodularis (PN) and atopic dermatitis (AD). Interleukin (IL)-31, often referred to as the “itch cytokine”, has...…
View Post 2 min This content is machine translated IBD and SARS-CoV-2 Vulnerable at the mercy of others While COVID-19 mRNA vaccines induce a robust systemic immune response in patients with inflammatory bowel disease (IBD), little is known about their efficacy in the mucosal immune system. Researchers have...…
View Post 8 min This content is machine translated GPP: from molecular principles to targeted therapy Therapeutic rationale for targeted IL-36 receptor inhibition The progress in the diagnosis and treatment of generalized pustular psoriasis (GPP) is remarkable. GPP has developed into a clearly defined, independent, IL-36-mediated autoinflammatory disease. Today, the high chronic disease...…
View Post 6 min This content is machine translated Chronic insomnia in adults: Guideline recommendations CBT-i as first choice – pharmacotherapy as secondary intervention Sleep disorders are often associated with pronounced daytime sleepiness, difficulty concentrating and increased feelings of stress. Diagnosis is generally based on the clinical history; if necessary, an actigraphy or polysomnigraphy...…
View Post 6 min This content is machine translated Colorectal cancer Is exercise better than medication? The presentation by a renowned Canadian oncologist on promising treatment options for colorectal cancer through exercise therapy caused quite a stir at this year’s ASCO. The results of a randomized...…
View Post 2 min This content is machine translated TREATswitzerland Register Evaluation of system therapies for AD In addition to conventional immunosuppressants, several monoclonal antibodies (biologics) and Janus kinase inhibitors (JAK-i) are now approved for the systemic treatment of atopic dermatitis (AD) in Switzerland. The primary objective...…
