This content is machine translated Squamous cell carcinoma Pembrolizumab as first-line therapy reduces mortality rate In a phase III trial, pembrolizumab improved overall survival in patients with recurrent or metastatic head and neck squamous cell carcinoma.
View Post 2 min This content is machine translated Eosinophilic asthma Mepolizumab now also available as pen and prefilled syringe At the beginning of August 2019, GSK received approval from the EMA for two new dosage forms of mepolizumab: The IL-5 antibody can now also be administered as a pen…
View Post 6 min This content is machine translated Hawthorn extract What are the pharmacological bases of the cardioprotective effects? The empirically proven positive effects of hawthorn extract range from vasodilation and endothelial modulation to influencing cholesterol metabolism and other cardiovascular-relevant parameters. This article highlights the underlying biochemical mechanisms of…
View Post 3 min This content is machine translated Colorectal Cancer Focus on combination therapies Triple for colorectal cancer – for the first time, studies have shown clear superiority of a triple combination of encorafenib, binimetinib and cetuximab in progressive metastatic colorectal tumors.
View Post 7 min This content is machine translated Aortic valve replacement The most frequent arrhythmias after AKE or TAVI Narrowing of the aortic valve is the most common acquired valve defect and is corrected by AKE or TAVI. However, despite advances in therapy, rhythm problems often occur. What to…
View Post 3 min This content is machine translated Chronic inflammatory skin diseases Positive long-term effects in moderate to severe psoriasis Recently published data from the multicenter LIBERATE study confirm the favorable benefit-risk profile of apremilast with long-term use. This is a significant advance for the treatment options of this patient…
View Post 1 min This content is machine translated Migraine prevention Peptide receptor blockade also effective and safe in the long term It is estimated that about 11% of the population suffers from migraine. Effective therapeutic options, especially for prophylaxis, are therefore urgently needed. Study results now also confirm long-term efficacy for…
View Post 4 min This content is machine translated Immunotherapies CAR-T for pemphigus vulgaris as a future therapeutic option? In recent years, great progress has been made in the study of autologous immunocellular therapies. The development of a target-specific chimeric antigen receptor (CAR) against pathogenetic autoreactive B-cell pemphigus vulgaris…
View Post 3 min This content is machine translated Migraine prophylaxis Expanded treatment options with CGRP antibodies Migraine is the most common neurological disorder and severely affects the quality of life of those affected. To prevent chronicity, prophylactic measures are becoming increasingly important in migraine therapy. The…
View Post 2 min This content is machine translated Autoimmune diseases Fatigue in Lupus and Co. A recent study shows that not only lupus erythematosus is characterized by fatigue symptoms, but also other autoimmune diseases with cutaneous involvement.
View Post 2 min This content is machine translated Migraine therapy Promising non-drug acute treatment via neurostimulation. External stimulation of the trigeminal nerve has already proven effective in migraine prevention. The great advantage is the drug-free treatment, due to which there are practically no side effects. Recent…
