This content is machine translated Systemic mastocytosis Pathological mast cell infiltration – a clinical challenge In patients with highly elevated tryptase levels, KIT mutation analysis from bone marrow is recommended. Especially in adults, a point mutation in codon 816 of the KIT gene can often…
View Post 7 min This content is machine translated Dermatomyositis Diagnostics and treatment – a current overview Pathognomonic skin signs of dermatomyositis include heliotrope erythema, Gottron papules, and Gottron signs. The determination of myositis-specific autoantibodies has an increasingly important role in the diagnosis. Regarding treatment options, intravenous…
View Post 3 min This content is machine translated Plaque psoriasis TYK2 inhibition shows great therapeutic potential Psoriasis is nowadays understood as a systemic disease, which is based on chronic inflammation. Research into the etiopathogenesis, as well as the establishment of new active substances, is progressing rapidly.…
View Post 4 min This content is machine translated Severe asthma No musclemen in the waiting room Many asthmatics, especially those with severe disease, report mobility problems and limitations in daily activities that severely affect their quality of life. Among the contributing factors, low muscle mass and…
View Post 4 min This content is machine translated Biologics for atopic dermatitis Symptom relief through targeted inhibition of inflammatory signaling pathways Monoclonal antibodies are systems therapeutics that block specific cytokines or receptors and can thus selectively influence individual activation cascades of the immune system. Both dupilumab and tralokinmab – the two…
View Post 3 min This content is machine translated Atopic dermatitis Multifactorial etiology with dysregulation of type 2 cytokines. Genetic predisposition, an impaired epidermal barrier with altered microbiome, and aberrant immune responses with type 2 inflammation are associated with the occurrence and activity of atopic dermatitis. Various provoking factors…
View Post 3 min This content is machine translated Chronic cough Asthma, COPD, or postinfectious? Anyone who struggles with a respiratory tract infection during the cold season almost always suffers from an unpleasant cough associated with it. This can be quite persistent, but usually disappears…
View Post 3 min This content is machine translated Hymenoptera venom allergy Summer, sun, insect bite Hymenoptera venom allergy – commonly called insect venom allergy – is one of the so-called “Big 3” of severe allergic reactions, along with food and drug allergies. No one is…
View Post 6 min This content is machine translated Alopecia areata: drug therapy Which method achieves the best hair growth rates? Alopecia areata (AA) manifests as acute or chronic non-scarring hair loss. Diphenylcyclopropenone and Janus kinase inhibitors have a significantly higher remission rate compared with the spontaneous course, especially in severe…
View Post 4 min This content is machine translated Biologics for psoriasis “Drug Survival” under the microscope The era of biologics has revolutionized the treatment options for patients with moderate to severe psoriasis in recent decades. Drug survival is an indicator of the longer-term efficacy and safety…
View Post 12 min This content is machine translated Which procedure for which age? Inhalation with children Up to 5% of children and adolescents in German-speaking countries live with diseases of the respiratory tract – especially the lungs – and have drug therapy in case of exacerbations,… CME-Test
