Studies have shown that altered immune cell transport and pathogenic immune cells are critical factors responsible for mucosal inflammation and tissue destruction in IBD. A defective intestinal barrier and microbial dysbiosis lead to such accumulation and local activation of immune cells, resulting in a pro-inflammatory cytokine loop that overrides anti-inflammatory signals and causes chronic intestinal inflammation.
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Partner
Autoren
- Prof. Dr. med. Michael Scharl
- Prof. Dr. med. Markus F. Neurath
Publikation
- HAUSARZT PRAXIS
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