This content is machine translated Pulmonary hypertension PH and lung diseases Pulmonary hypertension (PH) describes a hemodynamic condition with a pathological increase in pressure in the pulmonary vascular circulation. Clinically, PH causes reduced performance, shortness of breath, angina and syncope. Comprehensive...… CME-Test
View Post 33 min This content is machine translated CRC, AML and melanoma in focus Molecular mechanisms of tumor plasticity Tumor plasticity, epigenetic reprogramming and the dynamic tumor microenvironment shape the biology of CRC, AML and melanoma and influence their therapeutic vulnerability. Modern therapeutic approaches combine molecular profiles, TME signatures...… CME-Test
View Post 5 min This content is machine translated Friedreich's ataxia Interim analyses of the PROFA study show “Unmet needs” The PROFA study focuses, among other things, on patient-reported psychosocial effects of Friedreich’s ataxia (FRDA) at different stages of the disease. The study comprises a cohort of FRDA patients in...…
View Post 4 min This content is machine translated Study report Sphingolipid profile in early-stage primary biliary cholangitis Using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), a Polish research team discovered interesting new insights into the changes in sphingolipid metabolism in patients with early-stage primary...…
View Post 6 min This content is machine translated Angiosarcoma of the heart A diagnostic and therapeutic “black box” Primary angiosarcomas of the heart are among the rarest and most aggressive malignant tumors. The unspecific symptoms, rapid progression and complex differential diagnosis make early detection considerably more difficult. Despite...…
View Post 5 min This content is machine translated Ataxias Friedreich’s ataxia: when the energy metabolism attacks the nervous system Energy deficiency instead of pure oxidative stress: New data show that in Friedreich’s ataxia, disturbances in fatty acid and ketone body metabolism in particular contribute to selective neurodegeneration. The article...…
View Post 3 min This content is machine translated Risk of osteoporosis in autoimmune liver diseases Always determine bone density in PBC, PSC and AIH Studies show that primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) are associated with a significantly increased risk of developing osteopenia or osteoporosis. For this reason,...…
View Post 3 min This content is machine translated Neuroendocrine tumors Precision medicine in diagnostics and therapy Thanks to modern imaging and molecular characterization, neuroendocrine tumours can now be detected and classified in a much more targeted manner. New therapeutic procedures such as radioligand therapy and targeted...…
View Post 3 min This content is machine translated Case report: Complication after type 2 diabetes Topical corticosteroids lead to ketoacidosis Hyperglycemic crises due to topical corticosteroid use are extremely rare. In this case report, however, physicians were faced with an unusual case of diabetic ketoacidosis (DKA) triggered by the postoperative...…
View Post 12 min This content is machine translated NSCLC Bispecific antibodies for rare EGFR mutations Rare EGFR mutations such as exon 20 insertion changes have long been considered a therapeutic dead end in non-small cell lung cancer (NSCLC). Current data show that innovative mechanisms of...…
View Post 6 min This content is machine translated Type 2 diabetes - glycemic control and prevention of secondary diseases Utilizing pleiotropic cardio- and nephroprotective effects of SGLT-2-i and GLP-1-RA Type 2 diabetes is currently understood to be a multisystemic disease, with the prognosis being significantly influenced by cardiac and renal pathology. An early, multimodal therapeutic approach that goes beyond...…
