This content is machine translated Obesity Goodbye prosperity belly – welcome feel-good weight! The proportion of severely overweight or obese patients is steadily increasing. The common disease is seen more of a health disorder resulting from an unhealthy lifestyle. However, the consequences can…
View Post 4 min This content is machine translated Small Molecules Phosphodiesterase-4 as a therapeutic target in psoriasis – an update. The oral PDE-4 inhibitor apremilast has been an established treatment option for moderate to severe chronic plaque psoriasis and psoriatic arthritis for several years. And in a phase IIb study…
View Post 4 min This content is machine translated Anxiety and sleep disorders Phytotherapeutic agent has no effect on driving ability Anxiety and sleep disorders are common and are associated with a reduced quality of life. Sedatives such as benzodiazepines have anxiolytic effects but impair driving ability. This is associated with…
View Post 6 min This content is machine translated Diabetes mellitus Biomarker-associated clustering for improved treatment management. Phenotyping and subclassification of diabetic patients is becoming increasingly important to provide patient-adapted treatment options. Meanwhile, there are several cluster analyses that could reveal certain specific patterns of patient characteristics.…
View Post 7 min This content is machine translated Urothelial carcinoma The role of checkpoint inhibitors Immunotherapy is also becoming increasingly important in the treatment of urothelial carcinoma. Checkpoint inhibitors are already being used successfully, particularly in advanced tumors. Now, potential applications of avelumab, atezolizumab and…
View Post 14 min This content is machine translated Focus on diabetes and heart New studies and new recommendations Study data in recent years have highlighted the enormous extent to which type 2 diabetes mellitus (T2D) promotes the development of cardiovascular disease. In addition, it became clear that certain…
View Post 3 min This content is machine translated Heart failure SGLT-2 inhibitors – great therapeutic potential in HFrEF patients. In addition to the SGLT-2 inhibitor dapagliflozin, which was also approved by Swissmedic last July for the treatment of heart failure (HFrEF) in non-diabetics, another member of this drug class,…
View Post 2 min This content is machine translated Advanced high-grade serous ovarian cancer. HRD+ tumors: first PARP inhibitor approved for first-line maintenance therapy As the first and only PARP inhibitor, olaparib was recently approved by swissmedic for first-line maintenance therapy in patients with advanced, HRD-positive ovarian cancer. The addition of olaparib to bevacizumab resulted…
View Post 2 min This content is machine translated Heart failure Effectively reduce re-hospitalization in patients with iron deficiency Intravenous iron (III) carboxymaltose results in significantly fewer hospital readmissions in patients with heart failure and iron deficiency compared with placebo. This is the conclusion of a study published in…
View Post 5 min This content is machine translated Prevention of non-melanocytic skin cancer (NMSC). Nicotinamide – blockbuster among cell-protective substances It is well known that UV radiation exposure is considered a major cause of non-melanocytic skin cancer by damaging DNA and inhibiting antitumor immunity. A reduction in intracellular ATP concentration,…
View Post 4 min This content is machine translated BRAFV600E-mutated metastatic colorectal cancer (mCRC). Evidence for additional benefit of dual blockade An expert panel finds considerable added benefit in the dual-blockade encorafenib combined with cetuximab in the treatment of metastatic colorectal cancer with BRAFV600E mutation after prior systemic therapy. This is…
