This content is machine translated Chronic inflammatory bowel disease (CED) Two new biomarkers identified for targeted therapy Surrogate markers have an important role in the disease management of IBD. Researchers found evidence that microbial butyrate synthesis may predict therapeutic efficacy and thus play an important role in…
View Post 6 min This content is machine translated Therapy of metastatic HER2-positive breast carcinoma Is a cure possible soon? In recent years, the prognosis of metastatic HER2-positive breast carcinoma has been significantly improved by the development of new agents such as the antibody-drug conjugate (ADC) trastuzumab-deruxtecan and the HER2-targeted…
View Post 3 min This content is machine translated Pediatric operations When children wish for more pain medication Postoperative pain and pain-related impairments are still inadequately treated in many cases, not only in adults but also in children. In an analysis of pediatric patient populations, a group of…
View Post 4 min This content is machine translated Lipid management: LDL cholesterol reduction Add-on to statin therapy recommended in patients at high cardiovascular risk Numerous empirical studies confirm that there is a causal relationship between high LDL cholesterol levels and cardiac events. The current motto with regard to LDL cholesterol reduction is “the lower,…
View Post 3 min This content is machine translated BVDD expert assessment Vaccination against SARS-CoV-2 during immunomodulatory therapy. What should be considered in patients with chronic inflammatory skin diseases on immunomodulatory or immunosuppressive therapy? The Professional Association of German Dermatologists (BVDD) has published practical recommendations on this subject.
View Post 5 min This content is machine translated Myelofibrosis Treatment in transition With the introduction of the Janus kinase (JAK) inhibitor ruxolitinib, therapy for myelofibrosis has changed dramatically in recent years. Nevertheless, further innovation is needed, especially in the second line. Promising…
View Post 5 min This content is machine translated Gastroesophageal reflux disease (GERD) Alginate as an as-needed add-on therapy increases patient satisfaction The standard therapy for treating all manifestations of reflux disease is proton pump inhibitors (PPI). Despite a high success rate, there are occasional patients with an insufficient response to therapy.…
View Post 4 min This content is machine translated Acute generalized exanthematous pustulosis (AGEP). Not just a T cell-mediated disease? Immunopathological studies have shown that not only T cells play a role in drug reactions, especially in AGEP, but also IL36 cytokines and other mediators are involved. These findings are…
View Post 3 min This content is machine translated SGLT2 inhibitors Cardioprotective effect proven and found to be good – a statement One of the serious long-term consequences of diabetes mellitus is cardiovascular disease. Heart failure, in particular, is common in patients who have had diabetes for a long time. Recent study…
View Post 3 min This content is machine translated Angina pectoris Antianginal therapy shows no long-term benefit for prophylaxis Angina may persist or recur despite successful revascularization with percutaneous coronary intervention. In these cases, antianginal treatment is supplemented. To demonstrate the effectiveness of this approach, a clinical trial was…
View Post 2 min This content is machine translated Acne vulgaris Low vitamin D levels in acne patients Vitamin D modulates immune functions through effects on the innate and acquired immune systems and plays a role in various dermatological diseases. In a recently published study, significantly decreased vitamin…
