Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patients
    • Disease patterns
    • Diagnostics
    • Therapy
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Allergology and clinical immunology
    • General Internal Medicine
    • Anesthesiology
    • Angiology
    • Surgery
    • Dermatology and venereology
    • Endocrinology and Diabetology
    • Nutrition
    • Gastroenterology and Hepatology
    • Genetics
    • Geriatrics
    • Gynecology
    • Hematology
    • Infectiology
    • Cardiology
    • Nephrology
    • Neurology
    • Emergency and intensive care medicine
    • Nuclear Medicine
    • Oncology
    • Ophthalmology
    • ORL
    • Orthopedics
    • Pediatrics
    • Pharmacology and toxicology
    • Pharmaceutical medicine
    • Phlebology
    • Physical medicine and rehabilitation
    • Pneumology
    • Prevention and health care
    • Psychiatry and psychotherapy
    • Radiology
    • Forensic Medicine
    • Rheumatology
    • Sports Medicine
    • Traumatology and trauma surgery
    • Tropical and travel medicine
    • Urology
    • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
  • Log In
  • Register
  • My account
  • Contact
  • English
    • Deutsch
    • Français
    • Italiano
    • Português
    • Español
  • Publications
  • Contact
  • Deutsch
  • English
  • Français
  • Italiano
  • Português
  • Español
Subscribe
Medizinonline Medizinonline
Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patienten
    • Krankheitsbilder
    • Diagnostik
    • Therapie
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Fachbereiche 1-13
      • Allergology and clinical immunology
      • General Internal Medicine
      • Anesthesiology
      • Angiology
      • Surgery
      • Dermatology and venereology
      • Endocrinology and Diabetology
      • Nutrition
      • Gastroenterology and Hepatology
      • Genetics
      • Geriatrics
      • Gynecology
      • Hematology
    • Fachbereiche 14-26
      • Infectiology
      • Cardiology
      • Nephrology
      • Neurology
      • Emergency and intensive care medicine
      • Nuclear Medicine
      • Oncology
      • Ophthalmology
      • ORL
      • Orthopedics
      • Pediatrics
      • Pharmacology and toxicology
      • Pharmaceutical medicine
    • Fachbereiche 26-38
      • Phlebology
      • Physical medicine and rehabilitation
      • Phytotherapy
      • Pneumology
      • Prevention and health care
      • Psychiatry and psychotherapy
      • Radiology
      • Forensic Medicine
      • Rheumatology
      • Sports Medicine
      • Traumatology and trauma surgery
      • Tropical and travel medicine
      • Urology
      • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
Login

Sie haben noch keinen Account? Registrieren

  • Groundbreaking research findings from Ticino

The tumor likes “fat

    • News
    • Nutrition
    • Oncology
    • RX
    • Studies
    • Urology
  • 2 minute read

Future drugs could reduce fats in the cancer cell by inhibiting a specific, newly researched metabolic component. The tumor would be “starved out.” Results of a research group from Bellinzona.

The complex being researched is called the pyruvate dehydrogenase complex, or PDC for short. It is found in prostate cancer in the mitochondria and nucleus. Surprisingly, this means that mitochondria are fundamentally involved in tumor cell growth, contrary to a long-held theory. The mitochondria are considered “electricity power plants” and are responsible for the necessary energy production for the cell. The theory of Otto Warburg, winner of the Nobel Prize in Medicine, was that increased glucose intake, bypassing mitochondrial metabolism, was the main factor supporting tumor cell growth.

Now, however, it has been shown: The mitochondrion in particular is crucial for prostate tumor cells – because it can regulate fatty acid synthesis (lipogenesis) via PDC. PDC thus becomes an interesting target for future cancer therapies. The enzyme complex is about ten times more active in prostate tumor cells than in a normally growing cell. Tumor cells can only grow and metastasize if they produce lipids effectively. Increased glycolysis alone does little to help here, the study published in Nature Genetics showed.

Depriving the tumor of “food

The tumor cells produce a lot of lipids due to the strong activation of PDC. Conversely, can this mechanism be exploited to deprive the tumor of its “food”?

It is known that a high-fat diet increases the risk of prostate cancer, so overweight people experience an increase in risk. Now, this in no way means that tumor patients should follow a strict diet. This would probably do more harm than good.

 

 

The new findings on this “fuel effect” of lipids are in fact valuable because they reveal for the first time a very specific starting point for reducing fat in tumor cells: Pharmaceutical agents might be able to selectively inhibit the mitochondrial enzyme and thus also fatty acid synthesis, thus slowing tumor growth without harming normal cells.

Source: Chen J, et al: Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nature Genetics 2018. DOI:10.1038/s41588-017-0026-3 [Epub ahead of Print].

 

InFo ONCOLOGY & HEMATOLOGY 2018; 6(2): 4.

Autoren
  • Andreas Grossmann
Publikation
  • InFo ONKOLOGIE & HÄMATOLOGIE
Related Topics
  • Fatty acid synthesis
  • Lipids
  • PDC
  • Pyruvate Dehydrogenase Complex
  • Tumor growth
Previous Article
  • Three-country conference on headache in Bad Zurzach

Giant cell arteritis – Dangerous inflammation of the blood vessels

  • Angiology
  • Congress Reports
  • Neurology
  • RX
View Post
Next Article
  • Therapy for urinary incontinence in old age

Surgery, drugs and other approaches

  • Education
  • General Internal Medicine
  • Geriatrics
  • RX
  • Urology
View Post
You May Also Like
View Post
  • 6 min
  • DOAK optimization, ABC pathway and lessons learned from the FXI/XIa pipeline

Stroke prevention for atrial fibrillation 2025

    • Cardiology
    • Emergency and intensive care medicine
    • Endocrinology and Diabetology
    • Neurology
    • RX
    • Studies
View Post
  • 4 min
  • From symptom to diagnosis

Abdominal pain – Hernias

    • Cases
    • Education
    • Gastroenterology and Hepatology
    • General Internal Medicine
    • Radiology
    • RX
    • Surgery
    • Urology
View Post
  • 5 min
  • "Survey of Health, Ageing and Retirement in Europe" (SHARE)

Analysis of polypharmacy in ≥65-year-olds

    • General Internal Medicine
    • Geriatrics
    • Pharmacology and toxicology
    • Practice Management
    • Prevention and health care
    • Psychiatry and psychotherapy
    • RX
    • Studies
View Post
  • 8 min
  • New perspectives for clinics and research

Ageing, cellular senescence and Parkinson’s disease

    • Education
    • Geriatrics
    • Neurology
    • RX
View Post
  • 6 min
  • From early intervention to individualization

The new guidelines at a glance

    • Cardiology
    • Congress Reports
    • RX
    • Studies
View Post
  • 14 min
  • Artificial intelligence

Dr. ChatGPT: Large language models in everyday clinical practice

    • Cases
    • CME continuing education
    • RX
View Post
  • 11 min
  • COPD therapy

Drug therapy – Update 2025

    • CME continuing education
    • General Internal Medicine
    • Pneumology
    • RX
    • Studies
View Post
  • 13 min
  • Focus on prevention

Colorectal cancer screening – an update

    • CME continuing education
    • Gastroenterology and Hepatology
    • General Internal Medicine
    • Oncology
    • Prevention and health care
    • RX
Top Partner Content
  • Herpes zoster

    Zum Thema
Top CME content
  • 1
    Drug therapy – Update 2025
  • 2
    Colorectal cancer screening – an update
  • 3
    Aligning care with the patient
  • 4
    Participatory decision-making using the example of diets for type 1 diabetes
  • 5
    Colorectal cancer screening – an update

Newsletter

Sign up and stay up to date

Subscribe
Medizinonline
  • Contact
  • General terms and conditions
  • Imprint

Input your search keywords and press Enter.