Be Careful When Choosing Medications

Psychosis in Parkinson’s disease has significant consequences for patients and their families, impairs quality of life, and represents a major risk factor for mortality, among other things. A particular challenge in treatment is controlling hallucinations and delusions without impairing motor function. This is because reducing dopaminergic therapy can worsen mobility, and many antipsychotics can exacerbate Parkinsonism by blocking dopamine D2 receptors.