This content is machine translated Acute generalized exanthematous pustulosis (AGEP). Not just a T cell-mediated disease? Immunopathological studies have shown that not only T cells play a role in drug reactions, especially in AGEP, but also IL36 cytokines and other mediators are involved. These findings are…
View Post 4 min This content is machine translated Psoriatic arthritis (PsoA) HLA alleles as genetic biomarkers for PsoA – an update. Psoriatic arthritis (PsoA) is a common comorbidity of psoriasis. Despite the high prevalence, arthritic symptoms often remain undiagnosed. In addition to the CASPAR classification (“Classification Criteria for Psoriatic Arthritis”), there…
View Post 5 min This content is machine translated Moderate and severe plaque psoriasis From Immunopathogenesis to Highly Effective Therapies – Enduring Lesion Freedom as the Goal Translational approaches have revolutionized the treatment options for psoriasis. New findings in the field of epidermal immunopathology form the basis for the optimization of highly effective substances. The new generation…
View Post 2 min This content is machine translated Pancreatic Cancer Effectiveness of treatment depends on molecular prerequisites Pancreatic cancer is one of the greatest challenges in oncologic therapy. Mortality is extremely high despite intensive research. New treatment options are urgently needed. A team of researchers has now…
View Post 6 min This content is machine translated Diabetes phenotyping Biomarker-associated clustering verified by multiple studies Phenotyping and subclassification of diabetic patients is becoming increasingly important to provide patient-adapted treatment options. Meanwhile, there are several cluster analyses that could reveal certain specific patterns of patient characteristics.…
View Post 3 min This content is machine translated Non-small cell lung cancer and other solid tumors In the pipeline: KRAS G12C inhibitor Sotorasib The KRAS gene is one of the most frequently mutated oncogenes in human cancers and thus represents a promising target in the therapy of diverse solid tumors. Sotorasib is currently…
View Post 2 min This content is machine translated Heinz Nixdorf Recall Study When the heart vessels calcify – susceptibility also hereditary An interdisciplinary research team from the Medical Faculty of the University of Duisburg-Essen (UDE) has been able to prove that a person’s lifestyle is not the only factor responsible for…
View Post 13 min This content is machine translated Gene Therapy New ways in treatment Gene therapy, a long-time beacon of hope in medical research, is finally finding its way into the clinic to cure monogenetic diseases. This provides medicine with a new therapy that…
View Post 4 min This content is machine translated Cystic fibrosis Even one mutated gene increases the risk In autosomal recessive diseases such as cystic fibrosis (CF), one is dealing with the inheritance of two mutated genes. Previously, CFTR* expression levels of 50% were thought to be sufficient…
View Post 2 min This content is machine translated Migraine Common genetic variables to MS detected Although the symptoms and risk factors for migraine and multiple sclerosis (MS) often overlap, it is not known whether these two conditions are independent or share a common biological etiology,…
View Post 3 min This content is machine translated Immunotherapy Wider use for CAR-T cell treatment possible in the future? CAR-T cells have solved a central problem in cancer therapy – they make tumors visible again to the immune system. The initial successes in B-cell lymphomas are now attracting a…
