This content is machine translated Neuroprotection, resilience and cognitive health in old age Longevity & Brain Cognitive health in old age is not an inevitable fate, but can be influenced to a relevant extent by modifiable factors. The Lancet Commission 2024 concludes that a significant proportion...…
View Post 9 min This content is machine translated Parkinson's disease: progressive and clinically heterogeneous Individualized management of motor and non-motor symptoms Primary care providers are the central point of contact for the early detection of Parkinson’s disease, but collaboration with neurological specialists is essential. The diagnosis is still primarily made clinically....…
View Post 4 min This content is machine translated Dementia Delirium risks and treatment strategies Delirium is a common and serious neuropsychiatric disorder in elderly hospitalized patients. A large review shows: Numerous medications increase the risk of delirium, especially opioids, antipsychotics, benzodiazepines and certain antibiotics....…
View Post 5 min This content is machine translated Early rheumatoid arthritis C1M has potential as a biomarker The earlier rheumatoid arthritis (RA) is diagnosed, the better the prognosis. But easier said than done. Conventional clinical, serological and imaging markers often lack sufficient sensitivity in the early stages...…
View Post 5 min This content is machine translated Osteoporosis Risk-stratified therapy with osteoanabolic agents improves outcomes Patients with a very high or imminent fracture risk should be considered for (first-line) therapy with ostoanabolic substances. Both patient selection and planning of therapy sequences are decisive factors for...…
View Post 7 min This content is machine translated Longevity Medicine 2025 From anti-ageing to precision prevention Longevity Medicine in 2025 is less a marketing term than a clinical work program: moving away from fuzzy “anti-aging” promises towards measurable risk, biomarker and intervention logic. Drivers are a...…
View Post 9 min This content is machine translated Microbiome, inflammaging and affective/cognitive health Gut-brain axis in old age As we age, the composition and function of the gut microbiome, the integrity of the intestinal barrier and systemic immune regulation change. These changes are closely linked to the concept...…
View Post 6 min This content is machine translated What biomarkers reveal about "biological youth" - and what not (yet) Epigenetic ageing In recent years, epigenetic clocks based on DNA methylation have evolved from research tools to widely used biomarkers of biological ageing. They correlate not only with chronological age, but also...…
View Post 7 min This content is machine translated Focus on new therapeutic targets and senolytics Cellular senescence Cellular senescence is considered a key biological program that can exert both protective and potentially pathogenic effects in tissues across the lifespan. If senescent cells persist, they are associated with...…
View Post 7 min This content is machine translated Arterial elasticity, vascular ageing, endothelial function Longevity and cardiovascular health 2025 Vascular ageing is not a purely “biological” concept, but can be measured clinically – via arterial stiffness (e.g. PWV), endothelial function (e.g. FMD) and the resulting risk profiles. In parallel...…
View Post 8 min This content is machine translated Clinical significance, pathophysiology, diagnosis and management Frailty in COPD Frailty has established itself as a central concept in modern pulmonology in recent years. While the syndrome was originally described primarily as a geriatric phenomenon, more recent data shows that...…
