This content is machine translated What biomarkers reveal about "biological youth" - and what not (yet) Epigenetic ageing In recent years, epigenetic clocks based on DNA methylation have evolved from research tools to widely used biomarkers of biological ageing. They correlate not only with chronological age, but also...…
View Post 9 min This content is machine translated Microbiome, inflammaging and affective/cognitive health Gut-brain axis in old age As we age, the composition and function of the gut microbiome, the integrity of the intestinal barrier and systemic immune regulation change. These changes are closely linked to the concept...…
View Post 5 min This content is machine translated Chronic and hard-to-heal wounds Benefit from the advantages of outpatient negative pressure wound therapy If wound healing stagnates under conventional local treatment, the use of negative pressure wound therapy (N PWT) can be useful. Also known as “vacuum therapy” or “vacuum sealing therapy”, NPWT...…
View Post 6 min This content is machine translated Treatment of infected wounds and wounds at risk of infection Focus on an interdisciplinary perspective Experts from various specialist disciplines questioned common myths about wound care and presented solutions to improve the care situation. One quintessence was that modern wound care requires a paradigm shift...…
View Post 4 min This content is machine translated Wound treatment and dermal defect coverage Fish skin matrix for the treatment of complex ulcers The treatment of complex wounds, particularly large and deep skin defects, is a considerable challenge and there is a need for innovative approaches. As various case reports from clinical practice...…
View Post 7 min This content is machine translated Chronic inflammation as a driver of ageing Immunosenescence and inflammaging Immunosenescence and inflammaging are now regarded as central biological mechanisms of ageing. The age-related altered immune system is both weakened and chronically activated – with consequences for susceptibility to infection,...…
View Post 7 min This content is machine translated Gonarthrosis and coxarthrosis: update on conservative treatment Pain relief, targeted movement and relief Age-associated degenerative processes in the hyaline cartilage are common. In the case of symptomatic osteoarthritis at an early stage, conservative treatment is initially sought. In addition to classification and localization...…
View Post 7 min This content is machine translated Focus on new therapeutic targets and senolytics Cellular senescence Cellular senescence is considered a key biological program that can exert both protective and potentially pathogenic effects in tissues across the lifespan. If senescent cells persist, they are associated with...…
View Post 7 min This content is machine translated Arterial elasticity, vascular ageing, endothelial function Longevity and cardiovascular health 2025 Vascular ageing is not a purely “biological” concept, but can be measured clinically – via arterial stiffness (e.g. PWV), endothelial function (e.g. FMD) and the resulting risk profiles. In parallel...…
View Post 6 min This content is machine translated Hormone balance and longevity Ageing is not a substitution diagnosis In the longevity debate, “hormone balance” is often used as a synonym for “biologically younger”. Clinically, the term is only meaningful if it is linked to clearly defined axial disorders,...…
View Post 9 min This content is machine translated Neuroprotection, resilience and cognitive health in old age Longevity & Brain Cognitive health in old age is not an inevitable fate, but can be influenced to a relevant extent by modifiable factors. The Lancet Commission 2024 concludes that a significant proportion...…
