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Pharmacology and toxicology

373 posts
  • This content is machine translated Atopic Dermatitis in Children and Adults

Topically Applied “Small Molecules”: Janus Kinases or PDE-4 as Targets?

Intracellular target structures have gained importance as therapeutic targets for small-molecule therapeutics in atopic dermatitis (AD), and topical formulation ensures a localized pharmacological effect, thereby promoting a favorable safety profile...…
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  • 12 min
  • This content is machine translated The Brain and the Motivation to Eat

Why is it so hard to lose weight?

Obesity is the most common chronic disease in Western societies, with serious metabolic, cardiovascular, and psychosocial consequences. The therapeutic landscape has changed fundamentally: new-generation GLP-1 agonists achieve weight loss that,...…
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  • 4 min
  • This content is machine translated Preclinical Study on a Special Ginkgo biloba Extract

What role do proanthocyanidins play?

In a laboratory study published in 2025, proanthocyanidins (PACs) were isolated from the specialized ginkgo extract EGb 761® and evaluated using in vitro and in vivo assays in combination with...…
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  • 7 min
  • This content is machine translated Ischemic stroke: Are smaller or larger brain arteries affected?

Recent study findings on intravenous lysis therapy with fibrinolytic agents

Intravenous thrombolysis, with or without mechanical thrombectomy, is a key pillar in the treatment of ischemic stroke. There are now two approved treatment options available—alteplase and tenecteplase—and Phase II data...…
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  • 11 min
  • This content is machine translated Two approved substances in a new class

Treating Vasomotor Symptoms Without Hormones

Two substances belonging to a new class have recently been approved in Switzerland for the non-hormonal treatment of menopausal hot flashes. This changes the way patients are counseled, but it...…
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  • 9 min
  • This content is machine translated Psychedelic-assisted therapy

Current status of PAT

Psychedelic substances such as LSD, psilocybin and MDMA have increasingly become the focus of science and clinical practice in recent years. The substances are used as part of so-called psychedelic-assisted...…
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  • 6 min
  • This content is machine translated Psoriasis and Obesity: Effects of Incretin-Based Therapies

Clinical trials shed light on the potential of semaglutide, liraglutide, and tirzepatide

The bidirectional relationship between psoriasis and obesity is supported by a growing body of evidence, and it is now known that there are common inflammatory pathways. Current studies are investigating...…
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  • 8 min
  • This content is machine translated Hyperhidrosis: Keep a Cool Head

An Overview of Important Treatment Options

Excessive sweating can significantly impair quality of life. Gravimetry and the iodine-starch test are important diagnostic methods. Various options are available for the conservative treatment of primary hyperhidrosis. Topical preparations...…
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  • 14 min
  • This content is machine translated Rare Genodermatoses: From Diagnosis to Treatment

Darier’s Disease, also known as Follicular Keratosis – Update 2026

Darier’s disease is caused by pathogenic variants in the ATP2A2 gene. Advances in our understanding of its pathophysiology have paved the way for the development of innovative therapeutic approaches, but...…
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  • 6 min
  • This content is machine translated COPD: Biomarker-Guided Therapy Escalation

Biologics as the “new kids on the block”

What led to a paradigm shift in severe asthma several years ago is now also making its way into COPD treatment: targeted, phenotype-specific antibody therapy. Patients with severe COPD who...…
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  • 9 min
  • This content is machine translated Psychedelic-assisted therapy

Current status of PAT

Psychedelic substances such as LSD, psilocybin and MDMA have increasingly become the focus of science and clinical practice in recent years. The substances are used as part of so-called psychedelic-assisted...…
CME-Test
  • IBD matters

    Zum Thema
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    Clinical Presentation, Diagnosis, and Treatment of DSPN
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