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Pharmacology and toxicology

274 posts
  • This content is machine translated Glomerulonephritis: IgA nephropathy

Pathogenesis-based and nephroprotective therapeutic approaches

Immunoglobulin (Ig) A nephropathy is considered an important cause of end-stage renal failure. Therefore, from today’s perspective, IgA nephropathy should not be classified as a benign disease. Fortunately, the treatment...…
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  • 6 min
  • This content is machine translated Postmenopausal osteoporosis: long-term therapy concepts

Targeted use of antiresorptives and osteoanabolic agents and avoid “rebound” effects

Postmenopausal osteoporosis in women is a consequence of decreasing oestrogen levels and is associated with rapid bone loss (“high-turnover osteoporosis”). Long-term therapy concepts are required to achieve sustainable effects –...…
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  • 6 min
  • This content is machine translated Late-onset rheumatoid arthritis

More DMARDs can reduce glucocorticoids in LORA

Although glucocorticoids have no influence on the course of the disease, they are effective agents against symptomatic pain and inflammation in rheumatoid arthritis (RA). Patients with late onset RA (LORA)...…
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  • 16 min
  • This content is machine translated Pain and autism

Hurdles to pain treatment for autistic patients

In contrast to neurotypical patients, the brains of neurodivergent people develop differently from the norm. Autism is defined as a form of neurodivergence. For them, deviant stimulus processing is the...…
CME-Test
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  • 3 min
  • This content is machine translated Bronchodilators for asthma

The early bird … gasps for air

Current findings indicate that the biological clock plays an important role in the pathogenesis of bronchial asthma. However, the influence of circadian and seasonal rhythms on the response to bronchodilators...…
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  • 6 min
  • This content is machine translated Chronic musculoskeletal pain

How can the use of analgesics be optimized in multimodal therapy?

Musculoskeletal pain is complex and often underestimated. Pain sensitization plays an important role in chronification. In the long-term use of currently available analgesics, there may be conflicting goals with regard...…
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  • 6 min
  • This content is machine translated New evidence on genetics, pathophysiology and clinical significance

Migraine with and without aura – two different entities?

Migraine is one of the most common neurological disorders, and for decades it has been debated whether migraine with aura (MwA) and migraine without aura (MwoA) are merely different manifestations...…
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  • 6 min
  • This content is machine translated Treatment of vitiligo

Focus on patient perspective and disease activity

In vitiligo, hypopigmented or depigmented areas of skin occur as a result of an autoimmune disorder. The results of a large international survey confirm that vitiligo sufferers sometimes experience considerable...…
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  • 2 min
  • This content is machine translated Chronic pain

Nano-ECS modulator Adezunap improves therapy success

Cannabinoids have established themselves as therapeutic options in the treatment of pain in recent years. Nevertheless, patients can experience problems when using them, particularly with regard to tolerance. A new...…
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  • 4 min
  • This content is machine translated Gastrointestinal complaints

PPI regulation under the microscope

Proton pump inhibitors (PPIs) are very effective and suitable for certain indications and treatment periods, but there is an increasing trend towards “off-label” prescriptions. To ensure that temporary administration for...…
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  • 6 min
  • This content is machine translated Pediatric multiple sclerosis

Early high efficacy as the key to improving prognosis

Pediatric multiple sclerosis (POMS) is a rare but particularly challenging form of the disease. Children and adolescents with MS often experience more relapses, a greater lesion burden on MRI and...…
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